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Toxicology

Paumi Laboratory

Publications

Work Done Prior to joining the University of Kentucky

  • Hantgan RR, Paumi C, Rocco M, Weisel JW. Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization. Biochemistry. 38:14461-74 (1999)
  • Paumi CM, Ledford BG, Smitherman PK, Townsend AJ, Morrow CS. Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicity. J Biol Chem. 276:7952-6 (2001)
  • Paumi CM, Wright M, Townsend AJ, Morrow CS. Multidrug resistance protein 1 (MRP1) and MRP3 attenuate cytotoxic and transactivating effects of cyclopentenone prostaglandin, 15-deoxy-delta (12,14)-prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 42:5429-5437 (2003)
  • Paumi CM, Smitherman PK, Townsend AJ, Morrow CS. Glutathione S-Transferase (GSTs) Inhibit Transcriptional Activation by the Peroxisomal Proliferator-Activated Receptor g (PPARg) Ligand, 15-deoxy-delta (12,14)-prostaglandin J2 (15-d-PGJ­2). Biochemistry. 2004 Mar 2;43(8):2345-52.
  • O’Flaherty JT, Rogers LC, Paumi CM, Hantgan RR, Thomas LR, Clay CE, High KP, Chen YQ, Willingham MC, Kute TE, Rao A, Cramer SD, Morrow CS. 5-Oxo-ETE analogs and the proliferation of cancer cells. Biochim Biophys Acta. 2005 Oct 1;1736(3):228-36.
  • Paumi CM, Engels K, Iyer K, Georgiev O, Michaelis S, and Stagljar I. Identification of Proteins that Interact with the Yeast MRP Transporter Ycf1p, Using the Membrane Yeast Two-Hybrid (MbYTH) Split-Ubiquitin System, Mol Cell. 2007 Apr 13;26(1):15-25

Work Done in-part at the University of Kentucky

  • Paumi CM, Chuk M, Chevelev I, Stagljar I, and Michaelis S. Negative Regulation of the Yeast ABC Transporter, Ycf1p, by Phosphorylation within its N-Terminal Extension, In Press, J Biol Chem. 2008 Oct 3;283(40):27079-88.

Work Done at the University of Kentucky

  • Pickin KA, Ezenwajiaku N, Overcash H, Sethi M, Knecht MR, Paumi CM. Cka1p-dependent negative regulation of Ycf1p function is attenuated in response to Salt Stress, FEMS Yeast Res. 2010 Nov;10(7):839-57
  • Megaraj V, Zhao T, Paumi CM, Gerk PM, Kim R, and Vore M. Functional Analysis of Non-synonymous Single Nucleotide Polymorphisms of Multidrug Resistance Protein 2 (MRP2; ABCC2), Pharm and Gen. Submitted
  • Jungsuwadee P, Yong ZT, Stolarczyk EI, Paumi CM, Butterfield DA, St. Clair D, and Vore M. A single nucleotide polymorphism (SNP) of MRP1 (G671V) decreases GS-HNE transport, Mol. Can. Ther., Submitted
  • Lee ME, Singh K, Snider J, Shenoy A, Paumi CM, Stagljar I, and Park HO. The Rho1 GTPase in budding yeast is involved in cellular response to oxidative stress, Genetics, Submitted

Chapters In Books, Reviews

Work Done in-part at the University of Kentucky

  • Paumi CM, Chuk M, Chevelev I, Stagljar I, and Michaelis S. Yeast ABC Transporters and Their Interactors: New Technology that will Advance MRP Biology, MMBR Invited Review, 73(4), 2009

Work Done at the University of Kentucky

  • Stolarczyk E, Reiling C, and Paumi CM. A Role for Kinase Inhibitors in the treatment of ABC Transporter-Associated Diseases. Curr Pharm Biotechnol. 2010 Nov 30. [Epub ahead of print] (Invited Review)
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Page last updated Friday, April 01, 2011