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NIEHS Training Grant in Molecular Mechanisms of Toxicity

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The NIEHS training grant in Molecular Mechanisms of Toxicity is funded through the year 2010, and supports six predoctoral fellows.  Several areas of emphasis form the basis of the training program.  In each of these areas, the primary emphasis is on laboratory investigation of the basic mechanisms of toxicity.  A brief description of the focus of research in each of these areas, and a list of the Training Grant faculty in each area follows.

1.      Oxidative stress:  Reactive Oxygen Species (ROS) and reactive nitrogen species (RNS) are well-established mediators of cell transformation and cell death.  Understanding the mechanisms by which tissues respond to free radical generating agents is the key to preventing free radical mediated toxicity. 

            Training Grant Faculty

·        Daret St. Clair

·        Brett Spear

·        Howard Glauert 

·        Xianglin Shi        

2.      DNA Repair:  DNA damage is often cytotoxic and can also lead to deleterious long-term effects on human health, including mutagenesis, genomic instability, and cancer.  DNA repair is an important area in genotoxicology and forms the most effective defense system against DNA damage. 

            Training Grant Faculty

·        Zhigang Wang

·        Guo-Min Li

·        David Orren

·        Liya Gu

·        Andrew Pierce

·        John D'Orazio

3.      Biochemical Toxicology:  The research activities of several of the training grant faculty address fundamental mechanisms of toxicity related to molecular and biochemical toxicology.  Four general themes emerge:

a.      Regulation of gene expression, cell proliferation and apoptosis

b.      Metabolism and transport of xenobiotics

c.      Lipid Metabolism and cardiovascular disease

d.      Biochemical aspects of reproductive toxicology

Training Grant Faculty

·        Hollie Swanson

·        Vivek Rangnekar

·        Kevin Sarge

·        Davy Jones

·        Pat McNamara

·        Peter Crooks

·        Mary Vore

·        Bernie Hennig

·        Todd Porter

·        Tae Ji

·        Lisa Cassis

·      Alan Daugherty

4.      Neurotoxicology: The research activities address fundamental mechanisms by which chemicals, heavy metals, or ROS and RNS  induce neurotoxicity, including neurodegenerative diseases, oxidative damage induced by psychostimulants, and the role of antioxidant enzymes in protecting against neurotoxicity.       

            Training Grant Faculty

·        Will Maragos

·        Linda Dwoskin

·        Ed Kasarskis

·        Bob Yokel

·        Haining Zhu

5.      Immunotoxicology:  The major goal of the immunotoxicology group is to create an interactive environment for the training of graduate and postdoctoral fellows in mechanisms of immunotoxicology as it relates to immunological diseases. 

            Training Grant Faculty

·        Alan Kaplan

·        Don Cohen

·        Scott Bryson

·        Joe McGillis

·        Subbarao Bondada

·        Steve Shedlofsky

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