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Xianglin Shi, Ph.D.

William A. Marquard Chair in Cancer Research
Graduate Center for Toxicology
Director, Center for Research on Environmental Disease
Associate Dean for Nonclinical Faculty Development
College of Medicine

Mailing Address:

Graduate Center for Toxicology
1095 V.A. Drive
306 Health Sciences Research Building
Lexington, KY  40536-0305
Office: 232 HSRB
Phone: (859) 257-4054
Fax: (859) 323-1059

Research Interests

Dr. Shi's laboratory focuses on investigation on molecular mechanism of metal-induced carcinogenesis. We are studying carcinogenic metal-induced generation of reactive oxygen species, oxidative stress, activations of transcription factors, gene expression, cell migration and invasion, actin filament reorganization, transformation, tumorigenesis, DNA damage and repair, cell cycle regulation, and apoptosis. The long term goals are to provide a fundamental understanding concerning the mechanism of carcinogenic actions of metal compounds; to fill a need for the mechanistic information of cancer risk assessment for metal exposure; to propose methods for early detection; and to develop intervention and prevention strategies. The research interests of Dr. Shi's laboratory also include mechanism-based disease prevention and control. We are studying the antioxidant properties of various naturally occurring antioxidants and to develop them as chemopreventive agents. The methods to be used include electron spin resonance (ESR) spectrometer and general molecular biology techniques.

For a list of Dr. Shi's publications, please visit the PubMed web site.

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