Ok-Kyong
Park-Sarge,
Associate Professor
Physiology
Phone:
(859) 323-6067
Fax:
(859) 323-1070
e-mail:
okps@uky.edu
World Wide Web:
http://physiology.uky.edu/
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Research Interests The
expression of the steroid-target genes will be disturbed by molecules which can agonize or
antagonize steroid actions. Due to the critical roles that steroids play during female
reproductive cycles, any steroid agonistic or antagonistic compounds will severely impair
various physiological aspects of female reproductive physiology. Of particular interest
are environmental chemicals such as dioxin and PCBs that are products of modern society
and categorized as estrogenic or antiestrogenic chemicals, respectively and thus suspected
to cause developmental and reproductive toxicities. We are examining the effect of dioxin
and PCBs on estrogen- and progesterone-mediated transcription in female reproductive
tissues under normal and pathophysiological conditions.
Research Publications/Presentations
Ko C, In YH, Park-Sarge OK (1999) Role of progesterone
receptor activation in pituitary adenylate cyclase activating polypeptide (PACAP) gene
expression in rat ovary. Endocrinology (November issue)
O'Brien M, Park KS, In YH, Park-Sarge OK (1999) Characterization of the estrogen receptor
beta mRNA and protein in rat ovary. Endocrinology (October issue)
Shanmugam M, Krett NL, Maizels ET, Cutler RE, Peters C, Smith L, O'Brien ML, Park-Sarge
OK, Rosen ST, Hunzicker-Dunn M (1999). Regulation of protein kinase C delta by estrogen in
the MCF-7 human breast cancer cell line. Mol Cell Endocrinol 148:109-118
Telleria CM, Ou J, Sugino N, Park KS, Park-Sarge OK, Gibori G (1998) Estrogen receptor-b
mRNA expression in the pregnant rat corpora lutea and in the temperature sensitive SV-40
transformed luteal cell line: regulation by prolactin. Endocrinology 139-2432-244
Byers M, Kuiper GJM , Gustafsson Jan-Ake, Park-Sarge OK (1997) Estrogen receptor-b mRNA
expression in the rat ovary: down regulation by gonadotropins. Molecular Endocrinology
11:172-182
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