Jeff Moscow,
Associate Professor
Pediatrics
Phone:
(859) 323-1436
Fax:
(859) 257-6048
e-mail:
jmoscow@uky.edu
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Research Interests
My research interest is the molecular biology of drug transport, including drug transport into cancer cells and drug transport across lactating mammary epithelial cells.
Research Publications/Presentations
Sharif, KA, Moscow, J.A., and Goldman, I.D.
Concentrating capacity of the human reduced folate carrier (hRFC1) in
human ZR-75 breast cancer cell lines. Biochemical Pharmacology, 55,
1683-1688, 1998.
Moscow, J.A., Huang, H., Dunbar, C.,
Sorrentino, B., Zujewski, J., Chiang, Y., Cullen, E., Cusack, G., Carter,
C., Hines, K., Goldspiel, B., Leitman, S., Read, E.J., McDonagh, K., Abati,
A., Venzon, D., Sellers, S., Gottesman, M.M., Pastan, I. Nienhuis, A. and
Cowan, K.H. Engraftment of MDR1 and NeoR gene-transduced hematopoietic
cells following breast cancer chemotherapy. Blood, 94, 52-61, 1999.
Cowan, K.H., Moscow, J.A., Huang, H.,
O'Shaughnessy, J., Zujewski, J., Sorrentino, B., Carter, C., Cusack, G.,
Dunbar, C., Steinberg, S., Wilson, W., Read, E.J., Leitman, S., McDonagh,
K., Chow, C., Abati, A., Schneider, E, Chiang, Y., Gottesman, M.M., Pastan,
I. and Nienhuis, A. Paclitaxel chemotherapy following autologous stem cell
transplantation and engraftment of hematopoietic cells transduced with a
retrovirus containing the multidrug resistance cDNA (MDR1) in metastatic
breast cancer patients. Clinical Cancer Research, 5, 1619-1628, 1999.
Gong, M., Cowan, K.H., Gudas, J. and
Moscow, J.A., Isolation and characterization of the human reduced folate
carrier gene (RFC1) promoter. Gene, 233, 21-31, 1999.
Ma, D. Huang, H., and Moscow, J.A. Effects
of methotrexate exposure on reduced folate carrier RNA levels and
activity. Biochemical Biophysical Research Communications, 279, 891-898,
2000.
Gerk, P.M., Oo, C.Y., Paxton, E.W., Moscow,
J.A., and McNamara, P.J. Interactions between cimetidine, nitrofurantoin
and probenecid active transport into rat milk. Journal of Pharmacology and
Experimental Therapeutics, 296, 175-180, 2001.
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