Toxicology

Guo-Min Li, Ph.D.

Professor
James-Gardner Chair in Cancer Research
Graduate Center for Toxicology

Mailing Address:
Graduate Center for Toxicology
1095 V.A. Drive
306 Health Sciences Research Building
Lexington, KY  40536-0305
Office: 563 BPC
Phone: (859) 257-7053
Fax: (859) 323-1059
E-mail: gmli@uky.edu

Research Interests

Dr. Li's laboratory studies molecular mechanisms by which lost of DNA repair functions causes cancer and other human diseases, including neurological and neurodegenerative disorders. Specific projects in Dr. Li's laboratory include:

I. Biochemistry of DNA mismatch repair (MMR)

1. Regulation of MMR function by posttranslational modifications
2. MMR at the chromatin level
3. Enzymology of MMR

II. Cancer etiology, detection, and therapy related to MMR genes

1. Penetration of American Founder Mutations of MMR genes in Appalachian Kentucky
2. Identify and develop sensitive biomarkers for early detection of cancers caused by MMR defects
3. MMR-induced apoptosis in cancer chemotherapy

III. DNA hairpin repair and neurodegenerative diseases

1. Identify and characterize proteins required for the repair of DNA hairpins formed within (CAG)n/(CTG)n repeats
2. Determine DNA hairpin repair defects in patients with familial neurodegenerative diseases associated with CAG/CTG repeat expansion

For a list of Dr. Li's publications, please visit the PubMed web site.

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