Lisa A. Cassis, Ph.D.
Associate Professor
Division of Pharmacology
and
Experimental Therapeutics
College of Pharmacy
Phone:
Office: (859) 257-4749
Lab: (859) 257-2558
Fax:
(859) 257-7564
e-mail
lcassis@uky.edu
|
Research Interests Dr.
Cassis’ research focuses on molecular and functional examination of the
renin-angiotensin system, including the physiological/pathophysiological significance of
local tissue renin-angiotensin systems in adipose tissue and heart. Approaches towards
examination of local tissue renin-angiotensin systems include biochemical assessment of
enzymatic components necessary for angiotensin II (AII) synthesis, molecular
characterization of messenger RNA expression, pharmacologic examination of AII receptor
subtypes, and functional analysis of AII end-organ responses in adipose tissue and heart.
Specifically, a local tissue renin-angiotensin in adipose tissue is
under examination for contributions towards the development of obesity and obesity-related
hypertension. In heart, research focuses on the role of locally formed AII in altering
cardiac cell responses contributing to the development and maintenance of congestive heart
failure. Results from this research will contribute to the pharmacologic management of the
renin-angiotensin system in the disease states of obesity, obesity-related hypertension
and congestive heart failure.
Research Publications/Presentations
Cassis L. and Dwoskin L. Presynaptic Modulation of Neurotransmitter
Release by Endogenous Angiotensin II in Brown Adipose Tissue. J of Neural Transmission
34:129-137, 1992.
Cassis L. and Lodder R. Near-IR Imaging of Atheromas in Living Arterial
Tissue. Analytical Chem. 65:1247-1257, 1993.
Cassis L. Role of Angiotensin II in Brown Adipose Thermogenesis During
Cold Acclimation. Amer J Physiol. 265:E860-E865, 1993.
Cassis L. The Role of Angiotensin II in Defective Brown Adipose Tissue
Metabolism of Zucker Preobese and Adult Obese Rats. Amer J Physiol. 264:E453-E458, 1994. |
