IBS
601 BIOMOLECULES AND METABOLISM. (3)
An
introductory course devoted to the structure and function of proteins and
enzymes and the generation and storage of metabolic energy associated with the
metabolism of carbohydrates, lipids, and amino acids.
Prereq: CHE 107, CHE 230 and 232, or equivalent. BIO 152 is also recommended.
(Same as BCH 607).
IBS
602 BIOMOLECULES AND MOLECULAR BIOLOGY. (3)
A continuation of BCH 607. The topics discussed include the molecular
basis of
gene expression; molecular endocrinology; biochemistry of connective
tissue,
muscle,
erythrocyte, and the immune system; structure, function and metabolism
of membranes.
The sequence BCH 607, BCH 608 covers the material of BCH 811.
Prereq: BCH 607 or equivalent. (Same
as BCH 608).
IBS
603 CELL BIOLOGY. (3)
An introduction to cell biology and signaling focused on cell types and
architecture,
membrane structure, cytoskeletons,
mitochondria, cellular mechanisms of development,
cell
division, cell cycle, apoptosis and prokaryotic cell biology and modulation by
bacterial
pathogens. Prereq:
CHE 105, 107, 230 and 232; BIO 150, 152; or equivalent.
IBS
604 CELL SIGNALLING. (3)
An introductory course on cell biology and signaling focused on inter-
and intracellular
communication,
from the generation of signaling molecules to cellular responses, including
transcriptional
regulation. Examination of
cellular and molecular techniques important to
understanding
key advances in cell signaling will be included.
Prereq: CHE 105, 107, 230
and 232; BIO
150 and 152; or equivalents.
IBS
605 EXPERIMENTAL GENETICS. (2)
An introductory genetics course designed to expose first-year graduate
students to
contemporary
methods and concepts of genetic analysis.
Where possible, model systems
will be presented as paradigms to
illustrate important concepts. Prereq:
CHE 105, 107;
230 and 232;
BIO 150 and 152; or equivalents. (Same
as MI 604).
IBS
606 INTEGRATED BIOMEDICAL SCIENCES. (4)
Consideration of the function of the mammalian organism from a
perspective ranging
from the cellular/sub-cellular to the organ system and whole organ designed to
allow
students in
the IBS curriculum to develop a truly integrative appreciation of biologic function.
Prereq: IBS 601, 603 and
605.
PHA
621 ADVANCED PHARMACODYNAMICS. (3)
Small group discussion course for students of the natural sciences who,
using
drugs as
research tools, wish to understand basis of drug therapy.
The principles
and mechanism
of drug action on biochemical and physiological systems is
emphasized.
Prereq:
Consent of instructor.
PGY
502 PRINCIPLES OF SYSTEMS, CELLULAR AND MOLECULAR
PHYSIOLOGY. (5)
Advanced survey of major mammalian physiological systems at the
systems,
cellular and
molecular level; lectures, assigned reading, advanced texts or monographs,
demonstrations
and problem oriented study questions.
Prereq:
One year each, physics, general chemistry, PGY 206 or its equivalent.
(Same as
BIO 502).
STA
570 BASIC STATISTICAL ANALYSIS. (4)
Introduction to methods of analyzing data from experiments and surveys;
the
role of
statistics in research, statistical concepts and models; probability and
distribution
functions; estimation; hypothesis testing; regression and correlation;
analysis of
single and multiple classification models; analysis of categorical data.
Lecture,
three hours; laboratory, two hours.
Prereq: MA
109 or equivalent. Toxicology graduate students are encouraged to enroll
in the section(s), taught by Dr. Dick Kryscio, which will emphasize the design
and analysis of laboratory experiments.
TOX 600 ETHICS IN SCIENTIFIC RESEARCH. (2)
The course will commence with an overview of good laboratory practices
and
present them
as the basis of good scientific research, along with an overview of
quality
assurance and appropriate practices in data analysis and data
interpretation.
The course will then move to the ethics of human and animal
experimentation
and discuss the concepts of data and intellectual property, their
ownership and
access to them. The problems of reviewing other workers’
intellectual
property such as grant applications, research papers and other
intellectual
property will be addressed.
Prereq:
Research experience; consent of instructor. (Same as VS 600.)
BIO
615 MOLECULAR BIOLOGY. (3)
An integrative and functional approach to the regulatory aspects of
DNA, RNA
and proteins
in procaryotic and eucaryotic cells. Lectures and discussions with
readings in
original literature.
Prereq: A
course in genetics (e.g. BIO 404G) and a course in nucleic acids and
elementary molecular biology (e.g. BCH 608) or consent of instructor. (Same
as
BCH/MI
615.)
BIO
632 ADVANCED CELL BIOLOGY I. (3)
A molecular level treatment of cell structure and function derived from
current
experimental
approaches. Eukaryotes will be stressed. Topics will usually
include
membrane structure and function, the cytoskeleton and the extracellular
matrix, and
bioenergetics. Lectures and discussions with reading in the original
literature.
Prereq: BIO 404G or equivalent; coreq: BCH 607 or equivalent, or consent of
instructor.
BIO
633 ADVANCED CELL BIOLOGY II. (3)
This course is a companion to BIO 632. Topics will usually include a
molecular
level
discussion of gene structure, gene expression, and gene regulation, followed
by the cell
and molecular biology of cell proliferation, development, and
differentiation.
Lectures and discussions with reading in the original literature.
Prereq: BIO
404G of equivalent, BCH 607 or equivalent, or consent of
instructor.
MI
611 BIOPATHOLOGY (3)
The course will examine the mechanisms by which various biological,
chemical
and physical
agents injure susceptible hosts and the complex biochemical and
immunological
reactions which occur in response to injury. The host defense
mechanisms
will be illustrated by an analysis of selected human diseases and
animal model
systems with particular emphasis on the events at the molecular
and cellular
level.
Prereq: BCH
608 or concurrent, BIO/MI 494G or equivalents and consent of
instructor. (Same
as BIO 611.)
MI
616 BIOLOGY AND THERAPY OF CANCER. (3)
Biology of cancer will be discussed at the molecular, cellular and
organismic
level.
Emphasis will be placed on cellular signaling, apostosis and cell cycle
unique to
cancer cells, which affects tumor cell behavior and its interactions
with the host
immune system. The biology of
hematopoitic cells will also be included.
Clinicians active in treatment and research of various types of cancer will be
invited
to
participate in the lectures. Prereq:
BCH 501, 502, BIO 685. (Same
as MED 616.)
PHA
649 MOLECULAR PHARMOCOLOGY. (3)
The intent of this course is to describe the
molecular aspects of a variety of physiological systems that are subject to pharmacological
manipulation. Emphasis will be on the molecular genetics, biochemistry, and
subcellular organization and biology of these systems; and on the
pharmacological techniques used to study these systems.
Genetic diseases associated with these systems will also be described.
The course will focus on areas of research which represent the
forefront of modern pharmacological investigation.
Prereq: PHA 522, PGY 502,
BCH 501, 502, or consent of instructor. (Same
as PHR/TOX 649.)
PHR
664 THEORY AND PRACTICE OF DRUG METABOLISM. (3)
A broad overview of the chemistry of drug biotransformation with
emphasis on
experimental
considerations and analytic methodology for the isolation and
identification
of metabolites and the study of metabolic processes.
Prereq: BCH
607 and CHE 538 or consent of instructor.
TOX
650 CELLULAR AND HISTOTOXICOLOGY. (2)
ANA
636 ADVANCED NEUROANATOMY. (3-5)
The objectives include specific and detailed correlation of microscopic
and
ultrastructural
morphology of structures in the nervous system with function of
these
structures. Emphasis will be placed on structure-function relationships,
neurotransmitters,
chemical constituents of the nervous system, neuronal as well
as
non-neuronal cells, plasticity of the nervous system and developmental
biology. The
detailed content and emphasis will depend on both the background
and goals of
the students. Depending on number of credits a student registers
for, and the
topic and course orientation, laboratory work, library work, written
and/or oral
presentations may be a course requirement.
Prereq: ANA
511, 512, 513, 516, or equivalents, or consent of instructor.
BCH
610 BIOCHEMISTRY OF LIPIDS AND MEMBRANES. (3)
A lecture and seminar course devoted to intermediary metabolism of
lipids and
various
biochemical aspects of the structure, assembly and functions of
biological
membrane systems.
Prereq: CHE
232, CHE 444G, BCH 401G, 608 or 811. BCH 608 may be taken
concurrently.
BCH
611 BIOCHEMISTRY AND CELL BIOLOGY OF NUCLEIC ACIDS. (3)
A lecture and seminar course devoted to a study of the principles of
nucleic acid
chemistry and
to the role of nucleic acids in cellular function.
Prereq: BCH
401G, 608 or 811.
BCH
612 STRUCTURE AND FUNCTION OF PROTEINS AND ENZYMES. (3)
Primarily a lecture course devoted to the relationship of the structure
of protein
molecules to
their biological roles. Proteins will be discussed in terms of their
size, shape,
conformation, primary structure, catalytic mechanism and regulatory
properties.
Prereq: BCH
401G, 608 or 811; CHE 444G or consent of instructor. May be
taken
concurrently with BCH 608.
BIO
451G INTRODUCTORY ECOLOGY. (4)
A nonlaboratory course in basic ecology taught jointly by botany and
zoology
departments.
Will stress the ecosystem approach to understanding the
interrelationships
between organisms and their environment including current
environmental
problems. Lecture, three hours; recitation, one hour.
Prereq: BIO
150-153 or BIO 104-107 or consent of instructor.
BIO
542 HISTOLOGY. (5)
An intensive study of vertebrate histology at the
tissue, cell and subcell levels
with emphasis
on human tissues. Some knowledge of cell biology, biochemistry,
physiology
and anatomy is desirable. The laboratory involves study of prepared
microscope
slides. Lecture, three hours per week; laboratory, four hours per week.
Prereq: BIO
152 or BIO 315 or BIO 340 or consent of instructor.
BIO
544 EMBRYOLOGY. (5)
A comparative study of chordate development, stressing morphogenesis
and
reproduction
of vertebrate species and evolutionary changes in ontogeny.
Laboratory
devoted principally to development of the frog, chick and pig. Three
lectures and
two two-hour laboratories per week.
Prereq: BIO
340.
BIO
553 FISH BIOLOGY. (4)
This course explores the biology of fishes from an evolutionary
perspective.
Lectures
cover physiology, functional morphology, ecology, population biology,
behavior,
evolutionary relationships, and fisheries biology. Laboratory exercises
include
development of a fish collection; experiments in fish physiology, behavior
and ecology;
computer modeling of problems in fisheries biology; and field trips.
Lecture, two
hours; laboratory, four hours per week.
Prereq: BIO
150,151, 152; and 153 or consent of instructor.
CHE
522 INSTRUMENTAL ANALYSIS. (4)
The theory and application of instrumental methods of analysis.
Lecture, two
hours;
laboratory, six hours.
Prereq or
concur: CHE 422G or 444G.
CHE
532 SPECTROMETRIC IDENTIFICATION OF ORGANIC
COMPOUNDS. (2)
Problems involving the use of nuclear magnetic resonance, ultraviolet
and
infrared spectroscopy, mass
spectrometry and differential chemical reactivity in
determining
the structure of organic compounds. Discussion of chemical and
physical
methods for separation of mixtures of organic compounds.
Prereq: CHE
231 and CHE 232.
CHE
538 PRINCIPLES OF ORGANIC CHEMISTRY. (3)
A general survey of the field of organic chemistry. Topics emphasized
are:
mechanistic
principles relating molecular structure to reaction outcome,
stereoisomerism
and its effect on chemical reactivity, and simple molecular
orbital
theory as required to understand aromaticity and to predict the
occurrence
and stereochemistry of pericyclic reactions.
Prereq: CHE
232.
ES
610 ENGINEERING AND PHYSICAL SCIENCES IN ENVIRONMENTAL
SYSTEMS. (3)
Earth systems: environmental impacts of natural and human processes;
the role of water systems on the earth including surface water systems,
groundwater
systems, and
water quality and contamination systems; the role of atmospheric
systems on
earth including the nature and source of air pollutants, meteorological
principles,
radiation balance, climatology and air pollution, and air pollution control
methodology;
and processes and principles involved in waste producing
organizations.
Prereq:
Freshman chemistry.
ES
620 NATURAL, BIOLOGICAL AND MEDICAL SCIENCES IN
ENVIRONMENTAL
SYSTEMS. (3)
A survey course for students outside the biological and medical
sciences.
Concepts in
environmental systems, toxicology, ecology and the environments,
ecotoxicology
and environmental health.
Prereq: A background in physical sciences or introductory biology and
chemistry.
ES
630 LEGAL, SOCIAL AND ECONOMIC SCIENCES IN ENVIRONMENTAL
SYSTEMS. (3)
Jurisprudential history, ethics and rule of law, environmental
economics, history
of science,
governmental structures, process for development and enforcement
of standards,
social/political implications of environmental systems, regulatory
schemes for
environmental control.
GLY
530 LOW TEMPERATURE GEOCHEMISTRY. (3)
An introduction to sedimentary and environmental geochemistry,
including
carbonate equilibria, coal and petroleum geochemistry, and the geochemistry of
aqueous
contaminants.
Prereq: GLY
260 and MA 114 or consent of instructor.
MI
595 IMMUNOBIOLOGY LABORATORY. (2)
Laboratory in immunology and serology. Preparation, standardization,
and uses
of biological
products; serology. Laboratory; four hours.
Prereq:
BIO/MI 494G or concurrently; or consent of instructor. (Same as BIO
595.)
MI
618 MOLECULAR NEUROBIOLOGY (4)
This course provides knowledge base and analytical skills in the field
of molecular
neurobiology. An in-depth introduction to current technologies, their
rationale and
limitations,
will be the focus to address normal brain function and neuropathological
conditions.
Prereq: BCH 607 608, NEU 605, or
consent of instructor. (Same
as ANA/BIO/PGY 618).
MI
685 ADVANCED IMMUNOBIOLOGY. (4)
An introductory level graduate course surveying current trends in
immunology including the
organization and structure of cells relevant to immunity,
immunochemistry, types of immune responses, cellular immunology,
immunogenetics
and immunopathology.
Prereq : BCH
401G, or BCH 607 or 608 or equivalent, or consent of instructor.
(Same as
BIO 685.)
MI
707 CONTEMPORARY TOPICS IN IMMUNOLOGY. (2)
This course will deal with controversial and evolving areas of
immunology. Lectures in a given topic will be accompanied by student
discussion of
contemporary
literature.
Prereq: MI
685 or equivalent or consent of instructor. (Same as BIO 707.)
NEU
605 PRINCIPLES OF NEUROBIOLOGY. (4)
The objective of this course is to provide graduate students of diverse
backgrounds
with an introduction and overview of neurobiology. Areas covered
will include
neuronal and glial cell biology, neurotransmitters, signaling
mechanisms, neuroanatomy, and neuronal development. The course is designed
to provide a
brief overview of each of the areas and introduce students to
current
research questions. The course will consist of lectures and informal
presentations
in a ‘Journal Club’ format. The course will be interdisciplinary and
will be of
interest to graduate students in anatomy, biology, biochemistry,
immunology,
pharmacy, pharmacology, physiology, psychology and toxicology
and to
neurology and neurosurgery residents.
Prereq:
Introductory biochemistry courses, or equivalent, and/or consent of
instructor. (Same
as ANA/BCH/PGY/PHA 605.)
PHA 612 QUANTITATIVE PHARMACODYNAMICS:
PHARMACOKINETICS.
(3)
Quantitative treatment of dynamics of drug absorption, distribution,
metabolism
and
excretion, including development of both mathematical models and
model-independent
approaches for describing these processes.
Prereq: PHR 802 (0r equivalent), MA 114 and consent of instructor. (Same as
PHR
612.)
PHA
658 ADVANCED NEUROPHARMACOLOGY. (3)
A study of the general theories of the mode of action of drugs upon
nervous
tissue and a
review of the effects of analgesics, sedatives, hypnotics,
anesthetics,
tranquilizers, psychotomimetics, analeptics, antidepressants,
anti-convulsants
and drugs affecting motor dyskinesias upon neurons, synapses
and
functional components of the central nervous system.
Prereq: PGY
412G or equivalent and PHA 522 or equivalent; consent of
instructor.
PHR
510 MODERN METHODS IN PHARMACEUTICAL ANALYSIS. (5)
A course which deals with the application of modern analytical methods,
primarily
instrumental methods, in the determination of the strength, purity, and
quality of
drugs and pharmaceuticals. Laboratory exercises include analysis of
raw materials
and finished dosage forms. Lecture, three hours; laboratory, four hours. Prereq:
CHE 226.
PM
521 EPIDEMIOLOGY. (4)
Initial graduate level course in the principles of epidemiology and its
uses and
applications
in preventive medicine and public health. Lecture, three hours;
laboratory,
two hours per week.
Prereq: Graduate students in Public health and Nursing students in the
Community Health
Management component graduate program and consent of instructor.
PM
601 ENVIRONMENTAL AND OCCUPATIONAL HEALTH. (4)
An overview of occupational and environmental health problems,
toxicology
related to the work place and other
environments, industrial hygiene, safety, and
other topics
relevant to environmental health. Lecture, three hours; laboratory,
two hours per
week.
Prereq: PHA 603 and PGY 502 or equivalents, or consent of instructor.
PM
602 OCCUPATIONAL AND ENVIRONMENTAL HEALTH. (4)
A continuation of topics in PM 601. Lecture, three hours; laboratory,
two hours
per week.
Prereq: PM
601 or consent of instructor.
STA
671 REGRESSION AND CORRELATION. (2)
Simple linear regression, elementary matrix algebra and its application
to simple
linear
regression; general linear model, multiple regression, analysis of variance
tables,
testing of subhypotheses, nonlinear regression, step-wise regression;
partial and
multiple correlation. Emphasis upon use of computer library routines;
other special
topics according to the interests of the class. Lecture, three hours
per week.
laboratory, two hours per week for seven and one half weeks.
Offered the
first or second half of each semester.
Prereq: STA
570 or EDP 557.
STA
672 DESIGN AND ANALYSIS OF EXPERIMENTS. (2)
Review of one-way analysis of variance; planned and unplanned
individual
comparisons,
including contrasts and orthogonal polynomials; factorial
experiments;
completely randomized, randomized block, Latin square, and
split-plot
designs; relative efficiency, expected mean squares; multiple regression
analysis for
balanced and unbalanced experiments, analysis of covariance.
Lecture,
three hours per week; laboratory, two hours per week for seven and a
half weeks.
Offered the first or second half of each semester.
Prereq: STA
671.
TOX
660 CLINICAL TOXICOLOGY AND DRUG MONITORING (3)
A lecture and demonstration course designed to acquaint the student
with the
two main
areas of clinical toxicology. The first part of the course will cover the
scope of the
drug abuse problem in the U.S.A. and detail the emerging role of
the clinical
toxicologist in dealing with a wide variety of analytical and
medicolegal
problems associated with illicit drug detection. The second part of
the course
will cover the rapidly expanding area of clinical toxicology which
deals with
the monitoring of therapeutic drugs as they relate to the appropriate
clinical
management of patients.
Prereq: BCH
607 and 608, PHA 521 and 522 or equivalent with consent of
instructor. (Same as PAT 660.)
New
courses are continually being developed by faculty throughout the University.
Permission to substitute a new course for an elective should be
obtained from the DGS and the students' Advisory Committee.
