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Shaw, Y-J., Yang, Y-T., Garrison, J.B., Kyprianou, N. and Chen, C-S. Pharmacological exploitation of the alpha1 adrenoceptor antagonist doxazosin to develop a novel class of apoptosis-targeting antitumor agents that block intracellular protein kinase B/Akt activation. J. Med. Chem., 47: 4453-4462, 2004.
Keledjian, K., Garrison, B. J. and Kyprianou, N. Doxazosin inhibits vascular endothelial cell adhesion, migration and invasion. J. Cell. Biochem., 94:374-388, 2005.
Rennebeck, G., Martelli, M. and Kyprianou, N. Anoikis and Survival Connections in the Tumor Microenvironment: Is there a Role in Prostate Cancer Metastasis. Cancer Res., 65:11230-11235, 2005.
Zhu, B., Fukada, K., Zhu, H. and Kyprianou, N. Prohibitin and Cofilin are intracellular effectors of TGF-? signaling in prostate cancer cells. Cancer Research, 66:8640-8647, 2006.
Garrison, J.B. and Kyprianou, N. Doxazosin induces anoikis of benign and malignant prostate epithelial cells via a death receptor mediated pathway. Cancer Res., 66:464-472, 2006.
McKenzie, S. and Kyprianou, N. Apoptosis Evasion in Prostate Tumorigenesis: Significance in Therapeutic Resistance, J. Cell. Biochem.; 97:18-32, 2006.
Sutton, T.M., Yingling, M., Vyas, A., Atiemo, H., Borkowski, A., Jacobs, S.C. and Kyprianou, N. Finasteride targets prostate tissue vascularity by inhibiting cell adhesion and inducing apoptosis. The Prostate, 66:1194-1202, 2006.
Sakamoto, S., Ryan, A.J. and Kyprianou, N. Targeting Vasculature in Urologic Tumors: Current Therapeutic Value, J. Cell. Biochem, 2007, In Press.
Harris, A.M., Warner, B.W, Wilson, J.M., Becker, A., Rowland, R.G., Conner, W., Lane, M., Kimbler, K., Durbin, E.B., Baron, A.T. and Kyprianou, N. Effect of Alpha-1-Adrenoceptor Antagonist Exposure on Prostate Cancer Incidence: An Observational Cohort Study. J. Urology, 178(5):2176-2180, 2007.
Zhu, M., Partin, J.V., Bruckheimer, E.M., Strup S.E. and Kyprianou, N. TGF-beta signaling and androgen receptor status determine apoptotic cross-talk in human prostate cancer cells. The Prostate, in Press, 2007.
Garrison, J.B., Shaw, Y-J., Chen, C-S. and Kyprianou, N. Novel Quinazoline-based Compounds Impair Prostate Tumorigenesis by Targeting Tumor Vascularity. Cancer Research, December 1, 2007.
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