TRANSPLANT SURGERY RESEARCH
Basic Science Research
Oxidative stress induced cellular signaling in Epstein-Barr (EBV) related lymphoproliferative disorders (PTLD). We have investigated the role of direct oxidative stress as a promoting etiological factor in PTLD. We have shown that lipid peroxidation induced by cyclosporin A or H2O2 can promote transformation and proliferation of EBV immortalized B cells in vitro with up-regulation of the viral oncogene LMP-1, and that this process can be blocked by antioxidants. The cellular signaling events related to cyclosporine induced oxidative stress in EBV-B cells are under investigation. |
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Principal Investigator
Dinesh Ranjan, M.D.
dranj1@uky.edu
Senior Research Associate
Chagguo Chen, M.D.
Cchen01@email.uky.edu
Lab Location:
Room MN-327
AB Chandler Medical Center
800 Rose Street
Lexington, KY 40536
(859) 257-4474 |
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Clinical Research Activities
Transplant team physicians are currently collaborating in several multi-center industry-sponsored and investigator-initiated clinical trials. These are designed to assess the safety and efficacy of various FDA-approved as well as investigational drugs in prevention of rejection and various other conditions in organ transplant recipients. The overall focus is to improve quality of life and preserve graft function by minimizing side effects of chronic immunosuppression.
Our Principal Investigators are:
For additional information, please contact Saeed Shariaty. |
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Clinical Research Team
Nurse Clinician
Saeed Shariaty, LPN, CCRC
shariaty@uky.edu
Clinical Research Associate
Elisabeth Watkins, CCRP
Ewatk2@email.uky.edu
Lab Location:
Office: C-413
AB Chandler Medical Center
800 Rose Street
Lexington, KY 40536
(859) 257-9443
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