Center for Structural Biology

The Center for Structural Biology makes available to the research community at the University of Kentucky services and equipment for protein production and characterization. Protein production equipment includes equipment for bacterial, yeast, insect and mammalian cell culture, a large-scale cell-cracking device, and automated chromatography systems for protein and peptide purification. Protein characterization instruments include analytical spectroscopic instrumentation (circular dichroism, dynamic light scattering, fluorometer), an isothermal titration calorimeter, a TIRF illuminated microscope for single molecule and cellular fluorescence experiments, and a state-of-the-art instrument for collection of X-ray data from macromolecular crystals. The Center also oversees facilities for X-ray crystallography at Argonne National Laboratory (SERCAT), and computational resources for structure determination and modeling. A full time technician is available to assist in the use of instruments and to provide services.

PSA structure