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Sanders-Brown Center on Aging

L. Creed Pettigrew, M.D., M.P.H.

Director of the Commonwealth Center of Excellence in Stroke, Professor in the Departments of Neurology and Surgery (Neurosurgery)/Sanders-Brown Center on Aging, with a joint appointment at the Graduate Center for Toxicology.

Dr. Pettigrew received his medical training at the University of Texas Medical Branch in Galveston and his Master of Public Health degree at the University of Texas School of Public Health in Houston. He came to the University of Kentucky as Associate Director of the Commonwealth Center of Excellence in Stroke in 1989 and became Director in 1995.

Dr. Pettigrew has been awarded major grants from the National Institutes of Health and the American Heart Association for basic research in stroke, and he has made the University of Kentucky a nationally recognized center for clinical studies.

The Paul G. Blazer, Jr. Stroke Research Laboratory

Dr. Pettigrew's stroke research laboratory has an animal model of brain ischemia that makes it possible to test drugs which may be effective in minimizing damage and enhancing recovery from ischemia by preserving mitochondrial function.

Dr. Pettigrew and collaborators also have a transgenic animal that over-expresses TNF-a and inflammatory cytokine in its brain. This mimics the inflammatory response of human brain with stroke and therefore can lead to several avenues of research.

Present and Past Basic Research Grants

R01 NS047395. Focal Brain Ischemia in the TNFa-Transgenic Rat. 2004-2008

Department of Veterans Affairs Medical Research Service. Targeting the Mitochondrial Permeability Transition in Cerebral Ischemia. 2007-2011

AHA 0255433B. Focal Brain Ischemia in the TNFa-Transgenic Rat. 2002-2004.

R44-NS31479. Drug Potential of Anticonvulsants in Stroke Therapy.

K08 NS01505 NST. Eicosanoids Mediate Effects of PAF in Cerebral Ischemia. 1991-1996

Alzheimer's Association Pilot Research Grant. Metabolism, Perfusion, and Cognition in Vascular Dementia. 1994-1996

For Dr. Pettigrew's clinical research grants, see Clinical Trials.

Selected Publications

Korde AS, Pettigrew LC, Craddock SD, Waldmeier PC, Maragos WF. Protective effects of NIM811 in transient focal cerebral ischemia suggest involvement of the mitochondrial permeability transition. J Neurotrauma (In press, 2007).

Ishibashi H, Pettigrew LC, Funakoshi Y, Hiramatsu M. Pharmacokinetics of arundic acid, an astrocyte modulating agent, in acute ischemic stroke. J Clin Pharmacol (In press, 2007).

Pettigrew LC, Kasner SE, Albers GW, Gorman M, Grotta JC, Sherman DG, Funakoshi Y, Ishibashi H. Safety and tolerability of arundic acid in acute ischemic stroke. J Neurol Sci 2006;251:50-56.

Pettigrew LC, Kasner SE, Gorman M, Atkinson RP, Funakoshi Y, Ishibashi H. Effect of arundic acid on serum S-100b in Ischemic Stroke. J Neurol Sci 2006;251:57-61.

Greenberg SM, Rosand J, Schneider AT, Pettigrew LC, Gandy SE, Rovner B, Fitzsimmons B-F, Smith EE, Gurol ME, Schwab K, Laurin J, Garceau D. A Phase II study of tramiprosate for cerebral amyloid angiopathy. Alz Dis Assoc Dis 2006;20:269-274.

Korde AS, Pettigrew LC, Craddock SD, Maragos WF. The mitochondrial uncoupler 2,4-dinitrophenol attenuates tissue damage and improves mitochondrial homeostasis following transient focal cerebral ischemia. J Neurochem 2005;94:1676-1684.

Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang C-H, Stampfer M. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. JAMA 2004;291:565-575.

Robertson WC, Pettigrew LC. "Congenital" Horner's Syndrome and carotid dissection. J Neuroimaging 2003;13:367-370

Wechsler LR, Roberts R, Furlan A, Higashida R, Dillon W, Roberts H, Rowley H, Pettigrew LC, Callahan AS, Bruno A, Fayad P, Smith WS, Schulz GA. Factors influencing outcome and treatment effect in PROACT II. Stroke 2003;34:1224-1229