Commonwealth Center of Excellence in Stroke Clinical Trials

Sanders-Brown Center on Aging

The Commonwealth Center of Excellence in Stroke is the fulcrum of a broadly-based, intra-institutional collaboration to promote clinical research in stroke within UK. These activities are administered jointly through the Sanders-Brown Center and the Department of Neurology in the College of Medicine. The Stroke Program has collaborative partners in the Department of Emergency Medicine, the Division of Neurosurgery in the Department of Surgery, the Division of Neuroradiology in the Department of Diagnostic Radiology, the Department of Physical Medicine and Rehabilitation, the Division of Cardiology within the Gill Heart Institute, the NIH-funded General Clinical Research Center (GCRC) in the Chandler Medical Center, and the University of Kentucky Clinical Research Organization (UKCRO).

The Stroke Clinical Research Team

L. Creed Pettigrew, MD, Nedda Hughes, PA-C, Deborah Taylor, MS, Kathryn Vanderpool, RN, MS

The Sanders-Brown Stroke Team is always involved in a number of ongoing acute and long-term clinical trials designed to find ways to prevent and treat stroke and stroke disability.

To contact the Stroke Team, call 859-257-5560. Or UKMDs # 1-800-888-5533.

The Commonwealth Center of Excellence in Stroke has participated in the following major clinical trials in stroke:

Ongoing Clinical Trials in Stroke

U10 NS058967. UK NETT Clinical Hub. 2006-2011

U01S062835. Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT)Trial, a Randomized, Double-blind, Multicenter Clinical Trial 2010-2015

U01 NS040406. Albumin in Acute Stroke (ALIAS) Trial. 2006-2015

Ptcl-01373, D. Pharm, Ltd. Membrane-Activated Chelator Stroke Intervention (MACSI): a double-blind, randomized, placebo-controlled, parallel groups, multicenter Phase 3 pivotal study to assess the safety and efficacy of 1 mg/kg/day intravenous DP-b99 over 4 consecutive days versus placebo when initiated within nine hours of acute ischemic stroke onset.. 2006-2014

R01 NS38529. Secondary Prevention in Small Subcortical Strokes (SPS3). 2006-2012

R01 NS044876. Insulin Resistance Intervention After Stroke (IRIS) Trial. 2004-2014

AGA-006, G990318. Randomized Evaluation of Recurrent Stroke comparing PFO Closure to Establish Current Standard of Care Treatment (RESPECT PFO Clinical Trial). 2004-2011

Past Clinical Trials in Stroke

U01 NS39143 and NS43975. Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial. 2002-2008

R01 NS39987. Siblings with Ischemic Stroke (SWISS) Trial. 2003-2007

R01 NS36643. Warfarin versus Aspirin Symptomatic Intracranial Disease (WASID) Trial. 1998-2003

R01 NS40299. Hemicraniectomy and Durotomy upon Deterioration from Infarction Related Swelling: A Prospective, Randomized Clinical Trial (HeADDFIRST). 1998-2003

R01 NS34447. Vitamin Intervention in Stroke Prevention (VISP) Trial. 1996-2001

R01 NS2837. Warfarin Aspirin Recurrent Stroke Study (WARSS) and Antiphospholipid Antibodies and Stroke Study (APASS) and Hemostatic Activation Study and Genes in Stroke Study. 1992-2000

SR01 NS24456. North American Symptomatic Carotid Endarterectomy Trial. 1991-1997

R01 NS22611. Asymptomatic Carotid Artery Stenosis (ACAS) Collaborative Study. 1986-1994