SCoBIRC POST-DOCTORAL ALUMNI

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Gabrielle M. Curinga - gcuringa@uky.edu

Education

LeMonye College, B.Sc., 1994, Biology

University of Washington, Ph.D., 2003 Pathology

University of Kentucky, Postdoctoral Scholar, 2004, SCoBIRC.

Research Interests

Develeoping therapeutic strategies to enhance axon regeneration following spinal cord injury. My current project focuses on a gene therapy approach to mitigate inhibition by chondroitin sulfate proteoglycans which upregulated in the glial scar following injury.

Mentors

Dr. George Smith and Dr. Diane Snow

Funding

NIH T32 NRSA Post-doctoral Translational Neuroscience Training Grant, "Therapeutic Strategies for Neurodegeneration," 2007-2008.

University of Kentucky Minorities and Women in Underrepresented Areas Fellowship 2005-2007

Publications

Curinga GM, Snow DM, Mashburn C, Kohler K, Thaboben R, Caggiano AO, Smith GM (2007). "Mammalian-produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans." Journal of Neurochemistry. 102 (1): 275-88.

Heron PM, Sutton BM, Curinga GM, Smith GM, and Snow DM (2007). "Gene expression of axon guidance molecules in neuronal co-cultures." Journal of Neuroscience Methods. 159 (2): 203-14.

Yang H, Curinga G, and Giachelli CM (2004). "Elevated Extracellular Calcium Levels Induce Smooth Muscle Cell Matrix Mineralization in vitro." Kidney International. 66 (6): 2293-9.

Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, and Giachelli CM (2001). "Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfal and downregulation of smooth muscle lineage markers." Circulation Research. 89 (12): 1147-54.

Curinga G, Snow DM, Smith GM 2008. "Mechanisms regulating interpretation of guidance cues during development, maturation, and following injury." Reviews in the Neurosciences- In Press.

Curinga G, Smith GM. 2008. Molecular/genetic manipulation of extrinsic axon guidance factors for CNS repair and regeneration. Experimental Neurology 209(2):333-42.

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Radhika A Vaishnav - radhika.vaishnav@louisville.edu

Education

Maharaja Sayajirao University of Baroda, B.Sc., 1996, Zoology

Maharaja Sayajirao University of Baroda, M.S., 1998, Biochemisty

Loyola University Chicago, M.S., 2002, Molecular Biology

University of Kentucky, Ph.D., 2007, Physiology

University of Kentucky, Postdoctoral Scholar, 2007, SCoBIRC

Current Position

Assistant Professor, Neurology, University of Louisville, 2010-

Education

Maharaja Sayajirao University of Baroda, B.Sc., 1996, Zoology

Maharaja Sayajirao University of Baroda, M.S., 1998, Biochemisty

Loyola University Chicago, M.S., 2002, Molecular Biology

University of Kentucky, Ph.D., 2007, Physiology (Mentor: Thomas Getchell, Ph.D.)

University of Kentucky, Postdoctoral Fellow, 2007-2010, SCoBIRC (Mentor: Edward Hall, Ph.D.)

Research Interests

Post-translational protein modifications in neurodegenerative diseases; olfactory dynamics in aging and neurodegenerative disorders; biomolecular oxidative damage as a biomarker and therapeutic target; age-associated neurodegenerative diseases, stroke, traumatic spinal cord injury.

Funding

2007-2008 NIH-NIDA 1T32DA022738-01

National Institutes of Health and National Institute of Drug Abuse Ruth Kirchstein National Research Service Award “Therapeutic Strategies for Neurodegeneration.”

2008-2010 NIH-NINDS 1F32NS063744-01

National Institutes of Health and National Institute of Neurological Disease and Stroke Ruth Kirchstein National Research Service Award “Therapeutic Strategies for Spinal Cord Injury.”

Publications

E.D. Hall, R.A. Vaishnav, A.G. Mustafa “Antioxidant Therapies for Traumatic Brain Injury.” Neurotherapeutics, 2010; 7(1): 51-61.

K.M. Carrico, R.A. Vaishnav, E.D. Hall “Temporal and spatial dynamics of peroxynitrite-induced oxidative damage after spinal cord contusion injury.” J. Neurotrauma, [E-Pub] May, 2009.

R.A. Vaishnav, M.L. Getchell, L. Huang, M. Hersh, A.J. Stromberg, T.V. Getchell "Cellular and molecular characterization of oxidative stress in the olfactory epithelium of the Harlequin mutant mouse." J. Neurosci. Res., 2008; 86(1):165-182.

R.A. Vaishnav, M.L. Getchell, H.F. Poon, K.R. Barnett, W.M. Pierce, J.B. Klein, S.A. Hunter, D.A. Butterfield, T.V. Getchell "Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization." J. Neurosci. Res., 2007; 85(2):373-85.

M.L. Getchell, H. Liu, R.A. Vaishnav, A.S. Borders, J. Witta, N. Subhedar, W. de Villiers, A.J. Stromberg, T.V. Getchell "Temporal gene expression profiles of target-ablated olfactory epithelium in mice with disrupted expression of scavenger receptor A: impact on macrophages." Physiol. Genomics, 2006; 27(3):245-63.

H.F. Poon, R.A. Vaishnav, T.V. Getchell, M.L. Getchell, D.A. Butterfield "Quantitative proteomics analysis of specific protein expression and oxidative modification in aged mice brain - insights into compensatory mechanisms for lost protein activity due to age-related oxidative modification." Neurobiol. Aging, 2006; 27(7):1010-9.

H.F. Poon, R.A. Vaishnav (co-first author), D.A. Butterfield, M.L. Getchell, T.V. Getchell "Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes." J. Neurochem., 2005; 94, 380-392.

T.V. Getchell, H. Liu, R.A. Vaishnav, K. Kwong, A.J. Stromberg, and M.L. Getchell "Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablation." J. Neurosci. Res., 2005; 80(3):309-29.

K. Kwong, R.A. Vaishnav, Y. Liu, N. Subhedar, A.J. Stromberg, M.L. Getchell, and T.V. Getchell "Target ablation-induced regulation of macrophage recruitment into the olfactory epithelium of Mip-1alpha-/- mice and restoration of function by exogenous MIP-1alpha." Physiol. Genomics., 2004; 20(1):73-86.

S. Weijzen, P. Rizzo, M. Braid, R. Vaishnav, S.M. Jonkheer, A. Zlobin, B.A. Osborne, S. Gottipati, J.C. Aster, W.C. Hahn, M. Rudolf, K. Siziopikou, W.M. Kast, L. Miele "Activation of Notch-1 signaling maintains the neoplastic phenotype in Ras-transformed cells." Nature Medicine, 2002; 8(9):979-86