SCoBIRC FACULTY

Chen-Guang Yu, Ph.D., M.D.

Research Assistant Professor
Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine

Curriculum Vitae (pdf)

Chen-Guang Yu received his M.D. degree from Anhui Medical College in Anhui Province, China, in 1982. He received a Ph.D. in Pharmacology, from the Shanghai Second Medical University, Shanghai, China, in 1996. He performed a post-doctoral Associate at University of Miami, Miami, from 1998-2000 and was a faculty member (Assistant Scientist/Research Assistant Professor) at University of Florida from 2001 -2005. He joined Dr. Geddes' lab in the SCoBIRC, University of Kentucky in May of 2005, as a Scientist III. Dr. Yu is an expert in spinal cord injury model, SCI pain and the roles of calpain and ERK1/2 in spinal cord injury. He works with Dr. James W. Geddes on the pharmacological and gene therapy interventions for spinal cord injury.

Research Interests

My research interests are studying pathological mechanisms of spinal cord injury (SCI) and pharmacological/gene therapeutic interventions for SCI. More specifically, my research interests include the following area of spinal cord injury: 1) calpain inhibition as a therapeutic intervention following SCI using calpain inhibitors, lentiviral-calpastatin, and lentiviral-calpain shRNA; and 2) the roles of ERK1/2 cascade implicated in the secondary injury following SCI and ERK inhibition strategy for treatment of SCI.

Select Publications

Yu CG, Li Y, Raza K, and Geddes JW. Lentiviral calpain 1 shRNA attenuates the
progression of spinal cord injury
. Gene Therapy (In Preparation).

Yu CG, Raza K, Thompson LE, Saatman K, and Geddes JW. Calpastatin overexpression reduces calpain activation, neuronal loss, and locomotor deficits after contusion spinal cord injury in transgenic mice. (In Preparation).

Clark JM, Naga K, Yu, CG, and Geddes JW. Role of cyclophilin D in secondary spinal cord and brain injury. (In Preparation).

Yu CG, Yezierski RP, Joshi A, Raza K, Li Y, and Geddes J. Involvement of ERK2 in traumatic spinal cord injury. J Neurochemistry, 2010, 113:131-142.

Yu CG, Aashish Joshi, and Geddes JW. Intraspinal MDL28170 microinjection improves functional and pathological outcome following contusive spinal cord injury. J Neurotrauma 25(7):833-40, 2008.

Yu CG and Geddes JW. Sustained calpain inhibition improves locomotor function and tissue sparing following contusive spinal cord injury. Neurochem Res. 32:2046-53, 2007.

Yu CG and Yezierski RP. Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury. Brain Res. 138(2):244-55, 2005.

Yu CG, Fairbanks CA, Wilcox GL, and Yezierski RP. Effects of agmatine, IL-10, and cyclosporin on sponstanous pain behavior after excitotoxic spinal cord injury in rats. J Pain 4:129-140, 2003.

Yu CG, Ruenes G, Sanchez D, Marcillo AE, Dietrich WD, and Yezierski RP. Detrimental effects of hyperthermia on locomotor function and histopathological outcome following traumatic spinal cord injury in the rats. Neurosurgery. 49(1):152-158, 2001, discussion 158-159.

Yu CG, Jimenez O, Marcillo AE, Weider B, Bangerter K, Dietrich WD and Yezierski RP. Beneficial effects of modest systemic hypothermia on lomotor function and histopathological damage following contusion induced spinal cord injury in rats. J. Neurosurgery, 93:329-337. 2000.

Yu CG, Marcillo AE, Fairbanks CA, Wilcox GL and Yezierski RP. Agmatine improves locomotor function and reduces tissue damage following contusion spinal cord injury. NeuroReport. 11 (14), 2000.

Berens SA, Colvin DC, YU CG, Yezierski RP, Mareci TH. Evaluation of the pathologic characteristics of excitotoxic spinal cord injury with MR imaging. AJNR Am J Neuroradiol. 26(7):1612:22, 2005.

Yezierski RP, Yu CG, Mantyh PW, Vierck CJ, and Lappi DA. Spinal neurons involved in the generation of at-level pain following spinal injury in the rat. Neurosci. Lett. 361(1-3):232-6, 2004.

Caudle RM, Perez FM, King C, Yu CG, and Yezierski RP. NMDA receptor NR1 subunit expression and phosphorylation following excitotoxic spinal cord injury in rats. Neuroscience Lett. 349:37-40, 2003.

Plaunkett JA, Yu CG, Easton JM, Bethea JR, and Yezierski RP. Effects of interleukin-10 on pain behavior and gene expression following excitotoxic spinal cord injury in rats. Exp. Neurology 168:144-154, 2001.

Groman AL, Yu CG, Sanchez D, Ruenes GR, Daniels L and Yezierski RP. Conditions affecting the onset, severity,and progression of a spontaneous pain-like behavior after excitotoxic spinal cord injury. J Pain 2(4):229-240, 2001.

Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, Nguyen HO, Grocholski BM, Shoeman DW, Kehl LJ, Regunathan S, reis DJ, Yezierski RP, and Wilcox GL. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. PNAS (Proc. Nat. Acad. Sci. USA), 97(19):10584-10589, 2000.

 

Chen-Guang Yu

Contact Information

University of Kentucky
Chandler Medical Center
B465 Biomedical & Biological Sciences Research Building
741 S. Limestone Street
Lexington, KY 40536-0509

Tel: (859) 323-8770
Fax: (859) 257-5737
E-mail: cyu4@uky.edu