S. Randal Voss, Ph.D.
Associate Professor, Biology Department
Dr. Voss's research interests are in regenerative biology using a salamander model (Mexican axolotl). Salamanders are unparalleled in their ability to regenerate complex body parts, including spinal cord and limb. Dr. Voss's lab is using genomic and bioinformatic approaches to identify genes that are expressed differently between salamanders and mammalian models that show little or no functional response after injury. The goal is to build systems-level models that reveal how to induce a natural regenerative response. Dr. Voss is also using salamanders to identify quantitative trait loci for regeneration and metamorphic traits, and investigate vertebrate genome evolution.
Monaghan, J.R., Epp, L., Putta, S., Page, R.B., Walker, J., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., and Voss, S.R. 2009. Microarray and DNA Sequence Analysis of Transcription During Nerve-Dependent Limb Regeneration. BMC Biology 7:1.
Page, R.B., Monaghan, J.R., Walker, J.A., and Voss, S.R. 2009. An integrative model of transcriptional and morphological changes during TH-induced metamorphosis of the Mexican axolotl. General and Comparative Endocrinology 162:219-32.
Rao, N., Jhamb, D., Milner, D., Li, B., Song, F., Wang, M., Voss, S.R., Palakal, M., King, M.W., Nye, H.L.D., Cameron, J.A., Stocum, D.L. 2009. Proteomic analysis of blastema formation in regenerating axolotl limbs. BMC Biology 7:83.
Smith, J.J., Putta, S., Zhu, W., Pao, G.M., Verma, I.M., Hunter, T., Bryant, S.V., Gardiner, D.M., Harkins, T.T., and Voss, S.R. 2009. Genic regions of a large salamander genome contain long introns and novel genes. BMC Genomics 10:19.
Smith, J.J. and Voss, S.R. 2007. Chromosomal regions from bird and mammalian sex chromosomes were linked ancestrally. Genetics 177: 607-613.
Monaghan, J.R., Walker, J.A., Beachy, C.K., and Voss, S.R. 2007. Microarray analysis of early gene expression during natural spinal cord regeneration in the salamander Ambystoma mexicanum. Journal of Neurochemistry 101:27-40.
University of Kentucky
Tel: (859) 257-9888