SCoBIRC FACULTY

Karin R. Swartz, M.D.

Assistant Professor of Neurosurgery
Chief of Neurosurgery at the Lexington Veterans Affairs Medical Center

Research Interests

As a fellowship-trained spinal neurosurgeon, Dr. Swartz's clinical interests involve various spinal disorders, particularly spinal cord tumors. As a researcher, she has worked with traumatic brain injury and traumatic spinal cord injury. She has investigated the effects of gender, estrogen, and progesterone on spinal cord injury, and is currently involved in projects assessing the neuroinflammatory cascade that occurs after spinal cord injury, in an attempt to find potential treatment options.

Grants/Investigations

University of Kentucky Dept of Surgery Research Funding Grant (May 07-April 08): Telomerase and Vascular Glutamate Toxicity in an Ischemic Model of Stroke. (PI=Swartz)

Phase 1 Open-Label, Multi-Center Study to Evaluate the Safety and Tolerability of CT-322 Administered in Combination with Focal Brain Radiotherapy and Temozolamoide to Subjects with Newly Diagnosed Glioblastoma Multiforme. (PI=Young, SubInvestigator=Swartz) (2008-present)

Treatment of Lumbar Spinal Stenosis with X-STOP IPD in Moderately Symptomatic Patients (PI=Tibbs, SubInvestigator=Swartz) (2008-present)

Multi-Center Prospective, Randomized Controlled Trial Comparing Cervical Arthroplasty to Anterior Cervical Discectomy and Fusion (ACDF) for the Treatment of Cervical Degenerative Disc Disease (DDD) (PI=Tibbs, SubInvestigator=Swartz) (2008-present)

Representative Publications

MANUSCRIPTS

Origitano TC, Schwartz (sic) KR, Anderson D, Azar-Kia B, Reichman OH: Optimal clip application and intraoperative angiography for intracranial aneurysms. Surg Neurol 51(2):117-124, 1999

Swartz KR, Liu F, Sewell D, Schochet T, Campbell I, Sandor M, Fabry Z: Interleuken-6 promotes post-traumatic healing in the central nervous system. Brain Research 896:86-95, 2001

Moritz CH, Rowley HA, Haughton VM, Swartz KR, Jones J, Badie B: Functional MR imaging assessment of a non-responsive brain injured patient. Magn Reson Imaging.19(8):1129-32, 2001

Swartz KR, Fee DB, Trost GR, Waclawik A: Unilateral calf hypertrophy seen in lumbosacral stenosis: case report and review of the literature. Spine 27(18): E406-9, 2002

Swartz KR, Resnick DK, Iskandar BJ, Wargowski D, Brockmeyer D, Opitz JM: Craniocervical anomalies in Dubowitz Syndrome: Three cases and a literature review. Pediatr Neurosurg 38(5):238-243, 2003

Swartz KR, Fee DB, Dempsey RJ: Blossoming traumatic epidural hematoma. J Emerg Med. 25(4): 451-2, 2003

Swartz KR, Fee DB, Joy KM, Roberts KN, Sun S, Scheff NN, Wilson ME, Scheff SW: Gender differences in spinal cord injury are not estrogen-dependent. J Neurotrauma. 24(3):473-80, 2007

Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW: Effects of progesterone on experimental spinal cord injury. Brain Research. 1137(1):146-52, 2007

Meyer SC, Swartz KR, Johnson JP: Quadriparesis and spinal cord stimulation: case report. Spine. 32(19):E565-8, 2007

Swartz KR, Fee DB: Kummel’s Disease: Case report and literature review. Spine. 33(5): E152-5, 2008

Chen L, Swartz KR, Toborek M: A vessel microport technique for applications in cerebrovascular research. Jo Neurosci Res –accepted, Nov 2008

BOOKS AND CHAPTERS

Swartz KR, Trost G: Retroperitoneal Approaches To The Lumbosacral Spine. In: Batjer HH and Loftus CM (Eds) Textbook of Neurological Surgery: Principles and Practice. Lippincott Williams and Wilkins, Philadelphia (PA), 2003, Ch 193(pp2046-2051)

Swartz KR, Trost GR: Recurrent Lumbar Disk Herniation. In: Schlenk RP, Stewart T, and Benzel EC (Eds) Neurosurgical Focus 15(3): Chapter 10, 2003

Fabry Z, Ling C, Fee D, and Swartz KR: Innate and adaptive immune responses in the CNS: Role of innate mediators, T cells, and the complement system in traumatic injuries of the CNS. In: Ibarra A (Ed) The Role of Immune Cells in Neurodegenerative Diseases: 43-68, Chap 3, 2008 ISBN: 978-81-308-0261-9

ABSTRACTS

Swartz KR, Liu F, Sewell DL, Schochet T, Macvilay B, Sandor M, Campbell I, Fabry Z: Interleukin-6 cytokine promotes tissues repair in the central nervous system. FASEB Jo 14(6):A1113, 2000

Swartz KR, Liu F, Sewell DL, Schochet T, Fee D, Sandor M, Campbell I, Fabry Z: The role of interleukin-6 in tissue repair in the central nervous system. Soc Neurosci Abst 26(1):63, 2000

Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW: Does progesterone help after acute spinal cord injury? Nat Neurotrauma Soc Abst 22(10):1175, 2005

Swartz KR, Fee DB, Joy KM, Roberts KN, Scheff NN, Scheff SW: Estrogen (E2) as a therapeutic treatment following spinal cord contusion. Nat Neurotrauma Soc Abst 22(10):1197, 2005

Karin R. Swartz

Contact Information

University of Kentucky Neurosurgery
MS108
Lexington KY 40536

Tel: (859)323-5928
E-mail: krswar2@email.uky.edu