Stephen W. Scheff, Ph.D.
Dr. Scheff and his lab
Synaptic Plasticity and Recovery of Function Following Head Trauma and Spinal Cord Injury; Synaptic
Plasticity in Aging and Alzheimer's Disease
Clinically, Alzheimer's disease (AD) is characterized by progressive deterioration of an individual's cognitive functions, most clearly demonstrated by a loss of memory. Exactly what histopathologies are necessary or sufficient to produce these changes is still unknown. In AD there is significant loss of neurons which leads to a loss of synaptic contacts. It is important to determine what type of Central nervous system (CNS) compensatory response occurs in these individuals. These studies have determined that AD patients have a significant deficit in replacing lost synaptic contacts throughout many areas of the cortex, yet clearly their CNS attempts to compensate. In addition, the loss of synaptic connections closely correlates with a decline in cognitive function.
Scheff, S.W., Saucier, D.A., and Cain, M.E. A statistical method for analyzing rating scale data: The BBB locomotor score. Journal of Neurotrauma 2002, 19:1251-1260.
Scheff, S.W., Rabchevsky, A.G., Fugaccia, I., Main, J. and Lumpp, J. Experimental modeling of spinal cord injury: Characterization of a force-defined injury device. Journal of Neurotrauma 2003, 20:179-193.
Rabchevsky, A.G., Sullivan, P.G., Fugaccia, I. and Scheff, S.W. Creatine diet supplement for spinal cord injury in rats: influences on functional recovery and tissue sparing. Journal of Neurotrauma 2003, 20:659-669.
Anderson, K.J., Fugaccia, I., and Scheff, S.W. Fluoro-jade B stains quiescent and reactive astrocytes in the rodent spinal cord. Journal of Neurotrauma 2003, 20:1223-1231.
Scheff, S.W. and Dhillon, H.S. Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury. Neurochemical Research 2004, 29: 469-479.
Sullivan, P.G., Rabchevsky, A.G., Keller, J.N., Lovell, M., Sodhi, A., Hardt, R.P. and Scheff, S.W. Intrinsic differences in isolated brain and spinal cord mitochondria: implications for therapeutic interventions following injury. Journal of Comparative Neurology 2004, 474:524-534.
Sullivan, P.G., Springer, J.E., Hall, E.D. and Scheff, S.W. Mitochondrial uncoupling as a therapeutic target following neuronal injury. Journal of Bioenergetics and Biomembranes 2004 36: 353-356.
Gabbita, S.P., Scheff, S.W., Menard, R.M., Roberts, K., Fugaccia, I. and Zemlan, F.P. Cleaved-tau: a biomarker of neuroprotectant efficacy in traumatic brain injury. Journal of Neurotrauma 2005 22:83-94.
Hall, E.D., Sullivan, P.G., Gibson, T.R., Pavel, K.M., Thompson, B.M. and Scheff, S.W. Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury. Journal of Neurotrauma 2005 22:252-265.
Anderson, K.J., Fugaccia, I., and Scheff, S.W. Regional distribution of Fluoro-Jade B staining in the hippocampus following traumatic brain injury. Experimental Neurology 2005 193:125-130.
Scheff, S.W., Price, D.A., Hicks, R.R., Baldwin, S.A., Robinson, S., and Brackney, C. Synaptogenesis in the hippocampal CA1 field following traumatic brain injury. Journal of Neurotrauma 2005 22:719-732.
University of Kentucky
Tel: (859) 257-1412 ext. 270