SCoBIRC FACULTY

Timothy S. McClintock, Ph.D.

Boyarsky Professor,
Department of Physiology

Ph.D. Department of Zoology, University of Florida, 1989.

Research Interests

Summary of Relevant Projects
Regenerating tissues experience profound and widespread changes in gene expression. My laboratory investigates the functional genomics of neural regeneration. While much of this work is in the olfactory system, it has profound implications for improving regeneration in other neural tissues that do not so easily replace dying neurons. We use both microarrays and PCR-based differential amplification methods. One consequence of these studies is work that has a direct impact on research in neurotrauma. Handling the large numbers of affected transcripts that are identified in our expression profiling studies has impressed upon us the need for better bioinformatics. We therefore created SCIgenes, the database of genes and proteins whose expression is affected by spinal cord injury, nerve injury, or other related processes. This database provides a unique repository about genes affected by injury to nerves and spinal cord. It also includes a suite of data mining tools that allow the extraction of sets of gene products affected under numerous conditions.

Select publications

2005. Shetty, R., SC Bose, MD Nickell, JC McIntyre, D Hardin, AM Harris, and TS McClintock. Transcriptional changes during neuronal death and replacement in the adult olfactory epithelium. Mol. Cell. Neurosci. 30:90-107.

2005. Stepanyan, R, S. Haley and TS McClintock. Olfactory specific chymotrypsin-like serine protease from the aesthetasc tegumental gland of the lobster, Homarus americanus. Cell Tiss. Res. In press.

2005. Yu, T-T, J McIntyre, SC Bose, D Hardin, MC Owen and TS McClintock. Differentially expressed transcripts from phenotypically identified olfactory sensory neurons. J. Comp. Neurol. 483:251-262.

2004. Stoss, T, MD Nickell, D Hardin, and TS McClintock. A novel epithelial-specific transcript upregulated during neural regeneration in the lobster olfactory organ. J. Neurobiol., 58:355-368.

2003. Hollins, B, D Schweder, AA Gimelbrant, and TS McClintock. Olfactory enriched transcripts are cell type specific markers in the lobster olfactory organ. J. Comp. Neurol. 455:125-138.

2003. McClintock, TS and N. Sammeta. Trafficking prerogatives of olfactory receptors. Neuroreport In press (invited review)

2002. McClintock, TS. High throughput mRNA Analysis Techniques. Chemical Senses 27:289-291

2001. Gimelbrant, AA, S Haley, and TS McClintock.Olfactory receptor trafficking involves conserved regulatory steps. J. Biol. Chem. 276:7285-7290.

2000. McClintock, TS, F Xu, and SC Bose. Distribution of G-protein a subunits and neurotransmitter activation of Gai and Gaq in the brain of the lobster, Homarus americanus. J. Comp. Neurol. 422: 402-414.

2000. Hollins, B and TS McClintock. A lobster GABA receptor subunit expressed in neural tissues. J. Neurosci. Res. 59: 534-541.

2000. McClintock, TS. Molecular Biology of Olfaction. In: Neurobiology of taste and smell, 2nd edition. TE Finger, WL Silver, and D Restrepo, eds. Wiley, Chichester, UK. pp. 179-199.

2000. Gimelbrant AA and McClintock, TS. The intracellular trafficking of olfactory receptors.In: Recent Research Developments in Neurochemistry, Vol 3, part I. Research Signpost, Kerala, India. pp. 39-45.

1999. Xu, F, SC Bose and TS McClintock. A lobster G-protein coupled receptor kinase that associates with membranes and G-proteins in response to odorants and neurotransmitters. J. Comp. Neurol. 415: 449-459.

1999. Xu, F and TS McClintock. A lobster phospholipase C-b that associates with G-proteins in response to odorants. J. Neurosci., 19: 4881-4888.

1999. Gimelbrant, AA, TD Stoss, TM Landers and TS McClintock. Truncation releases olfactory receptors from the endoplasmic reticulum of heterologous cells. J. Neurochem., 72: 2301-2311.

1998. Mankad, R, AA Gimelbrant and TS McClintock. Consensus Translational Initiation Sites of Marine Invertebrate Phyla. Biol. Bull., 195: 251-254.

1998. Xu, F, B Hollins, TM Landers and TS McClintock. Molecular cloning of a lobster Gb-subunit and Gb expression in olfactory receptor neuron dendrites and brain neuropil. J. Neurobiol. 36: 525-536.

Timothy McClintock

Contact Information

Department of Physiology
800 Rose St.
Lexington, KY 40536-0298

Tel: (859) 323-1083
Fax: (859) 323-1070
E-mail: mcclint@uky.edu