SCoBIRC FACULTY

Gregory Neal Barnes, MD., PhD.

Assistant Professor,
Department of Neurology

Research Interests

Award from NINDS entitled" Molecular Basis of Mossy Fiber Sprouting in Epilepsy" Number 1 K08 NS 019910-01 NEST - This grant combines histology, immunocytochemistry, molecular biology, hippocampal culture explant technology, transgenic mice, and adenoviral mediated gene transfection to systematically investigate the role of the axonal guidance molecules such as semaphorins in mossy fiber sprouting and develop the methodology to study other potential candidate genes activated during epileptogenesis.

Representative Publications

Slevin, J.T., Barnes, G.N., and Vanaman, T.C. (1988) Perturbation of Hippocampal Membrane-associated Activity of Protein Kinase C and an Inhibitor after a Generalized Seizure. Soc. Neurosci. Abstracts, 14 (1): 574

Barnes, G.N., Vanaman, T.C., and Slevin, J.T. (1989) Synaptic Plasma Membrane Protein Phosphatase 2A May Regulate the Autophosphorylation of cAMP and Ca+2/CaM Dependent Protein Kinases. Soc. Neuroscience Abstracts, 5 (1): 194

Barnes, G.N., Vanaman, T.C., and Slevin, T.C. (1990) Increased Ca+2/CaM Dependent Kinase II Autophosphorylation in the Kindling Model of Epilepsy. Neurology, 40(S 1): 329

Barnes, G.N., Vanaman, T.C. and Slevin, J.T. (1990) Amino Acid Analysis and Sequencing of Rat Brain Protein Phosphatase 2A. Soc. Neurosci. Abstracts, 16 (2): 1181

Barnes, G.N., Vanaman, T.C., and Slevin, J.T. (1991) A Role for Protein Phosphatase 2A in Epileptogenesis. Natl. Student Research Forum, 32 (1): 459

Slevin, J.T., Barnes, G.N., Farrar, O.J., Alcala, R.M., and Vanaman, T.C. (1992) Generalized Tonic-Clonic Seizures Induced in Rats by Intraventricular Administration of Okadiac Acid. Soc. Neuroscience Abstraets, 17 (3): 3233

Barnes, G.N., Swoboda, K., Dougherty, F. and Urion, D.K. (1997) Bilateral Band Heterotopias and Meningoencephalitis in a Patient with Glutaric Aciduria Type I. Neurology, 48 (3), (suppl. 2): A401

Barnes, G.N., Luo, Y.L., Ebens, A., and McNamara, J.O. (1999) Differential Expression of Multiple Semaphorin Genes in Rat after Kainic Acid Induced Status Epilepticus. Annals Neurology, 46 (3):537

Barnes, G.N., Luo, Y.L., Ebens, A., and McNamara, J.O. (1999) Anatomical and Temporal Specific Patterns of Semaphorin Gene Expression in Rat Brain after Kainic Acid Induced Stares Epilepticus. Soei. Neurosei. Abstr., 25 (2): 1793

Barnes, G.N., Luo, Y.L., Ebens, A., and McNamara, J.O. (1999) Anatomical and Temporal Specific Patterns of Semaphorin Gene Expression in Rat Model of Limbic Epileptogenesis, Epilepsia, 40 (suppl.7): 7

Barnes, G.N., Luo, Y.L., and McNamara, J.O. (2000) Parallel Regulation of Sema 3C and Sema 3C Receptor Expression in CA1 Pyramidal Cell Layer of Rat Hippocampus after Kainic Acid Induced Status Epileptics, Soci. Neurosci. Abstr., in press

Barnes, G.N., Luo, Y.L., and McNamara, J.O. (2000) Stares Epilepticus is Necessary but not Sufficient to regulate Neuropilin Gene Expression in Mouse Hippocampus after Kainic Acid Status Epilepticus, Epilepsia, in press

Barnes, G.N. (1990) The Role of Ca+2 Dependent Protein Kinases and Protein Phosphatase 2A in the Kindling Model of Epilepsy. PhD Thesis, University of Kentucky Press

Barnes, G.N., Slevin, J.T., and Vanaman, T.C. (1995) Rat brain Protein Phosphatase 2A: An Enzyme Which May Regulate Autophosphorylated Protein Kinases. Ar. Neurochemistry, 64, pp. 340-353