Rheumatology Research Laboratory at the University of Kentucky College Of Medicine Division of Rheumatology

Research Papers

Kapoor M, Kojima F, Qian M, Yang L, Crofford LJ. Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferators-activated receptor gamma; regulation by prostaglandin E2 via the phosphatidylinsositol 3-kinase and Akt pathway. J Biol Chem; 2007; 282:5356-66.

Kapoor M, Kojima F, Yang L, Crofford LJ. Sequential induction of pro- and anti-inflammatory protaglandins and peroxisome proliferators-activated receotpr-gamma during normal wound healing: a time course study. Prostaglandins Leukot Essent Fatty Acids; 2007; 76:103-12.

Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood; 2007 Apr 23 Epub ahead of print.

Kapoor, M., Kojima, F., Qian, M., Yang, L. and Crofford, L.J. Microsomal Prostaglandin E Synthase-1 Deficiency Is Associated With Elevated Peroxisome Proliferator Activated Receptor Gamma: Regulation By Prostaglandin E2 Via The Pi3 Kinase And Akt Pathway. Journal of Biological Chemistry 2006 (Epub).

Kapoor, M*., Kojima, F*., Qian, M., Yang, L. and Crofford, L.J. Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis. FASEB J, 2006 (Epub).

Review Articles

Kojima F*, Kapoor M*, Kawai S and Crofford LJ. New insights into eicosanoid biosynthetic pathways: implications for arthritis. Expert Review of Clinical Immunology, 2 277-291, 2006.

Kapoor M, Kojima F and Crofford LJ. Arachidonic acid-derived eicosanoids in rheumatoid arthritis: implications and future targets Future Rheumatology 1, 323-330, 2006.

Kapoor M*, Kojima F*, Appleton I, Kawai S and Crofford LJ. Major enzymatic pathways in dermal wound healing: Current understanding and future therapeutic targets. Current Opinion in Investigational Drugs 7:418-22, 2006.

Kapoor M, Nomiyama T, Bruemmer D, Kojima F, and Crofford LJ. Growth factors and cytokines: Emphasis on their role in wound healing and atherosclerosis. Current Anaesthesia and Critical Care. 17, 13-20, 2006.

Srinivasan DM*, Kapoor M*, Kojima F and Crofford LJ. Growth Factor Receptors: Implications in Tumor Biology. Current Opinion in Investigational Drugs 2005 6(12):1246-9.

*Equal first author contribution.

Abstracts and Presentations

Kojima, F., Kapoor, M., Yang, L. & Crofford, L.J. Prostaglandin E2 activates Epac1/Rap1 signaling pathway via elevation of cAMP in synovial fibroblasts from patients with rheumatoid arthritis. American College of Rheumatology, Washington, DC, on November 10-15, 2006. (Oral presentation).

Kapoor, M., Kojima, F., Yang, L. & Crofford, L.J. Temporal Profile of Cyclooxygenase-2 derived Prostaglandins and PPARγ during normal wound healing: Profiling Inflammation and Resolution. 16th Wound Healing Society Meeting May 14-17 2006 Scottsdale, Arizona (USA). (Oral presentation).

Kapoor, M., Kojima, F., Qian, M., Yang, L. & Crofford, L.J. Effects of Microsomal PGE Synthase-1 Genetic Deletion and Subsequent Prostaglandin E2 Inhibition on Peroxisome Proliferator-Activated Receptor Gamma. American College of Rheumatology, Washington, DC, on November 10-15, 2006. (Poster presentation).

Kapoor, M., Kojima, F., Qian, M., Yang, L. & Crofford, L.J. Shunting of Prostanoid Biosynthesis in Microsomal PGE Synthase-1 Null Embryo Fibroblasts: Regulation of Inducible Nitric Oxide Synthase and Nitrite. American College of Rheumatology, Washington, DC, on November 10-15, 2006. (Poster presentation).

Jansen A, Kojima F, Kapoor M, Yang L, Kinne RW, Crofford LJ and Kunisch E. Prostaglandin E2 is an Essential Modulator for TNF-α-induced Expression of Pro-inflammatory/pro-destructive Mediators in Rheumatoid Synovial Fibroblasts: Regulation via the Prostaglandin E2-receptor EP2 through a cAMP-independent Pathway. American College of Rheumatology, Washington, DC, on November 10-15, 2006. (Poster presentation).

Kojima, F., Kapoor, M., Yang, L., Crofford, L.J. Prostaglandin E2-mediated Epac1/Rap1 and cAMP signaling pathway in synovial fibroblasts from patients with rheumatoid arthritis. Keystone Symposia, Eicosanoids in Inflammation and Chronic Diseases, Park City, Utah January 2006 (Poster presentation)

Kapoor M, Kojima F, Yang L, Crofford LJ. Temporal profiles of cyclooxygenase-2 derived prostaglandins and PPAR-gamma during normal wound healing: profiling inflammation & resolution. Keystone Symposia, Eicosanoids in Inflammation and Chronic Diseases, Park City, Utah January 2006 (Poster presentation)

Kapoor M, Crofford LJ, and Kojima, F. Differential pattern of eicosanoid production in microsomal prostaglandin E synthase-1 knockout embryonic fibroblasts. Eicosanoids and other Bioactive Lipids in Cancer, Inflammation and Related Diseases. San Francisco September 2005. (Poster Presentation)

Recent Publications