Radiation Medicine

Vivek Rangnekar, Ph.D.
Professor and Alfred Cohen Chair in Oncology Research
Associate Director for Translational Research, Markey Cancer Center
Combs Research Building
744 Rose Street 326
Lexington, KY 40536
Phone: (859) 257-2677
Email: vmrang01@email.uky.edu

RESEARCH INTERESTS:

• Cancer
• Apoptosis
• Tumor Suppressors
• Cell Signaling

EDUCATION:

• B.S., University of Bombay, 1976
• M.S., University of Bombay, 1979
• Ph.D., University of Bombay, 1983
• Post-doctoral Training, University of Chicago 1983-1986

SELECTED PUBLICATIONS:

Y.Zhao, R. Burikhanov, J. Brandon, S. Qiu, B.J. Shelton, B. Spear, S. Bondada, S. Bryson, and V.M. Rangnekar (2011) Systemic Par-4 inhibits non-autochthonous tumor growth. Cancer Biol Ther. 12(2):152-157.

T. Shrestha-Bhattarai and V.M. Rangnekar (2010) Cancer-selective apoptotic effects of extracellular and intracellular Par-4. Oncogene 29:3873–3880.

R. Burikhanov, Y. Zhao, A. Goswami, S. Qiu, S. Schwarze, andV. M. Rangnekar. (2009) The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell 138:377-388. doi:10.1016/j.cell.2009.05.022.

Book Chapters (invited, non-peer-reviewed):

J. M. D. Plate and V. M. Rangnekar (1988), Immunoprecipitation of interleukin-1 receptors  from murine  cell lines. Progress in Leukocyte Biology Volume 8,  Monokines and Other Non-Lymphocytic  Cytokines, (Alan R.  Liss, Inc., New York.) pp.167-174. Editors : M. C. Powanda,  J. J. Oppenheim, M. J. Kluger, and C. A. Dinarello.

V. M. Rangnekar* and M.P. Mattson (2000), Pivotal role of the leucine zipper domain protein Par-4 in neuronal cell apoptosis: in Recent Research Developments in Neurochemistry (Research Signpost, Trivandrum). Volume 3, 125-134. * corresponding author.

V. M. Rangnekar (2001), Apoptosis by Par-4 protein. Programmed Cell Death: Cellular and Molecular Mechanisms. (Elsevier Science, Inc., NY). Editors: M. P. Mattson, S. Estus, and V. M. Rangnekar. volume 1, pp.215-236.

P. Ranganathan and V. M. Rangnekar (2005) Regulation of Cancer Cell Survival by Par-4.   Ann. New York Acad. Sci. 1059, 76-85.

K. M. Vasudevan, P. Ranganathan, and V. M. Rangnekar (2005) Regulation of Par-4 by oncogenic Ras.  Methods in Enzymology.  (Elsevier Science, Inc., NY). Editors: Bill Balch, Channing Der and Alan Hall. Volume 407, pp. 422-442.

GRANTS:

Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-4
Source: NIH⁄NCI. From 07⁄01⁄08 to 06⁄31⁄13
Activation of the Par-4 Extrinsic Pathway for Suppression of Lung Cancer
Source: Kentucky Lung Cancer Research Program. From 12⁄01⁄2010 to 11⁄30⁄2012