Biology Research Programs
Molecular genetic analysis (c-Ki-ras-2; HER-2/neu; p53; microstaellite instability and TGF-b receptor II mutation) of pancreatic adenocarcinoma: Detection of circulating tumor cells in peripheral blood and the spectrum of gene alterations in primary tumor will provide leads for future radiation and chemotherapy strategies.
P53 and HER-2/neu gene analysis in primary tumor of breast adenocarcinoma patients undergoing Bone Marrow Transplantation will detect occult tumor cells in peripheral blood stem cell pharisees samples to prevent transfusion of tumor cells.
Head and Neck Tumors
Analysis of gene alterations in primary tumor, surgical margins and normal tissue using fluorescent in-situhybridization (FISH) and polymerase chain reaction.
Regulatory and functional role of EGR-1: In-vitro and in-vivo role of basal and radiation-induced EGR-1 expression levels are being assessed to understand tumor resistance to radiation. Molecular Basis of Grid Therapy Growth inhibition, apoptosis and gene expression analysis in cell lines exposed to radiation with grid therapy to understand the role of cytokines.
Cervix and Ovarian Cancer (Korean Collaboration)
H-ras point mutation and expression analysis in primary tumor of cervical and ovarian cancer versus clinicopathological correlation.
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