Radiation Medicine

Biology Research Programs

Pancreatic Adenocarcinoma

Molecular genetic analysis (c-Ki-ras-2; HER-2/neu; p53; microstaellite instability and TGF-b receptor II mutation) of pancreatic adenocarcinoma: Detection of circulating tumor cells in peripheral blood and the spectrum of gene alterations in primary tumor will provide leads for future radiation and chemotherapy strategies.

Breast Adenocarcinoma

P53 and HER-2/neu gene analysis in primary tumor of breast adenocarcinoma patients undergoing Bone Marrow Transplantation will detect occult tumor cells in peripheral blood stem cell pharisees samples to prevent transfusion of tumor cells.

Head and Neck Tumors

Analysis of gene alterations in primary tumor, surgical margins and normal tissue using fluorescent in-situhybridization (FISH) and polymerase chain reaction.

Prostate Adenocarcinoma

Regulatory and functional role of EGR-1: In-vitro and in-vivo role of basal and radiation-induced EGR-1 expression levels are being assessed to understand tumor resistance to radiation. Molecular Basis of Grid Therapy Growth inhibition, apoptosis and gene expression analysis in cell lines exposed to radiation with grid therapy to understand the role of cytokines.

Cervix and Ovarian Cancer (Korean Collaboration)

H-ras point mutation and expression analysis in primary tumor of cervical and ovarian cancer versus clinicopathological correlation.

If you have further questions, please call or email:

Jackie Sims 
(859) 323-1144 or (859) 323-6486
University of Kentucky Chandler Hospital
Dept. of Radiation Medicine
800 Rose Street
Lexington, KY 40536-0293