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Satin
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JONATHAN SATIN, Ph.D.
Professor
Ph.D. Emory University, 1989
Office: MS-503 Medical Center 0298
Tel: (859) 323-5356
Lab: MS-514 Tel: (859) 323-2918
E-mail: jsatin1@uky.edu
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Cardiac contractile function is reciprocally linked to cardiac morphogenesis during development.
Therefore, to understand diseases of development we need to understand the basis for development
of heart function. A second important reason to study heart development is that many embryonic
genes are re-expressed in adult diseased states. Our lab studies the electrophysiological
function of the heart during embryonic development, and adult diseased states. Our emphasis is
on ion channel contributions to embryonic development and heart disease. Ion channels are integral
membrane proteins that allow intracellular flux of ions from outside to inside cells. Ion
channels are controlled by voltage and by a variety of intracellular kinases and phosphatases. A
major focus of the lab is to study a novel mechanism whereby a proteolytic fragment of the L-type
calcium channel serves a dual role - as a ionic current modulator, and as a transcription factor.
A second major area of study is human heart development using human embryonic stem cells as a
model system. A major benefit of study embryonic stem cell derived heart cells is their potential
as a cell source for future cell replacement therapies for heart disease.
Other Publications
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