Physiology

JENNIFER STEVENSON MOYLAN, Ph.D. Assistant Professor Ph.D. University of Arizona, 1994 Office: MS-607A Medical Center 0298 Tel: (859) 323-2721 E-mail: jennifer.moylan@uky.edu Curriculum Vita (pdf)

The olfactory system does two unique things: It detects odors and it replaces injured neurons by activating resident tissue-level stem cells, even in adults. My lab investigates the molecular physiology of both of these processes. We use physiological genomics techniques, such as microarrays, to observe system-wide effects and then use techniques focused on individual processes or genes, such as targeted gene deletion (gene knockout), electrophysiology, biochemistry, and anatomy, to plumb the depths of regulatory networks of proteins controlling function. The mouse is our primary experimental model, though for certain questions we continue to use the unique advantages of the lobster olfactory system.

Recent Publications:

Li, Y.-P., S.H. Lecker, Y. Chen, I.D. Waddell, A.L. Goldberg, M.B. Reid. TNF-a increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E2-20k. FASEB J 17: 1048-1057, 2003.

Reid, M.B., J. Lännergren, and H Westerblad. Respiratory and limb muscle weakness induced by TNF-a: involvement of muscle myofilaments. Am. J. Resp. Crit. Care Med. 166: 479-484, 2002.

Reid, M.B. and W.J. Durham. Generation of reactive oxygen and nitrogen species in contracting skeletal muscle: potential impact on aging. Ann. N.Y. Acad. Sci. 959: 108-116, 2002.

Reid, M.B., J. Lännergren, and H Westerblad. Respiratory and limb muscle weakness induced by TNF-a: involvement of muscle myofilaments. Am. J. Resp. Crit. Care Med. 166: 479-484, 2002.

Li, Y.-P., S.H. Lecker, Y. Chen, I.D. Waddell, A.L. Goldberg, M.B. Reid. TNF-a increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E2-20k. FASEB J 17: 1048-1057, 2003.

Other Publications