Physiology

JOHN MCCARTHY, Ph.D. Assistant Professor Ph.D. University of Oregon, 1995 Office: MS-583 Medical Center 0298 Tel: (859) 323-8083 Lab: MS-541, MS-533 Tel: (859) 323-8079, (859) 323-8083 E-mail: jjmcca2@uky.edu Curriculum Vita (pdf)

My primary research project is focused on trying to understand the importance of circadian rhythms in skeletal muscle biology. Circadian rhythms are biological cycles that occur over approximately a 24 hour period and are most easily observed in the sleep-wake cycle. The laboratory, using microarray technology, recently made the unique and exciting discovery that skeletal muscle, like other peripheral tissue such as the kidney and liver, has a relatively small set of genes with a circadian pattern of expression. In an effort to understand the role of circadian rhythms in skeletal muscle function and maintenance, we are using this gene set to develop a working model which will aid us in formulating specific hypotheses concerning the function of circadian rhythms in skeletal muscle.

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