Physiology

MARCIELLE DEBEER, Ph.D. Associate Professor Ph.D. University of Stellenbosch, South Africa, 1992 Office: CTW-527 Health Sciences Building 0200 Tel: (859) 323-4933 ext. 81379 E-mail: mdebeer@uky.edu Curriculum Vita (pdf)

Area of research focuses on HDL metabolism during the acute phase and the development of atherosclerosis. Specific interests are how HDL size and composition changes during the acute phase with a particular focus on the acute phase reactant serum amyloid A protein (SAA), which is an apoprotein of HDL. Cell culture is employed to study the interaction of acute phase HDL with specific cell surface receptors involved in the development of atherosclerosis and animal models are used for in vivo reverse cholesterol transport experiments. Adenoviral vectors are often employed to express genes of interest in cultured cells or animal models.

Recent Publications

De Beer, M.C., Webb, N.R. Whitaker, N.L., Wroblewski, J.M., Jahangiri, A., Van der Westhuyzen, D.R. and De Beer, F.C. SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL. Arterioscler Thromb Vasc Biol. 2009; 29:1298-303

De Beer M.C., Van der Westhuyzen D.R., Whitaker N.L., Webb N.R. and De Beer F.C. SR-BI-mediated selective lipid uptake segregates apoA-I and apoA-II catabolism. J Lipid Res. 2005;46:2143-50.

De Beer, M.C., Castellani, L.W., Cai, L., Stromberg, A.J., de Beer, F.C., Van der Westhuyzen, D.R. ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res. 2004. 45: 706-715.

Other Publications