Physiology

MARCIELLE DEBEER, Ph.D. Associate Professor Ph.D. University of Stellenbosch, South Africa, 1992 Office: CTW-527 Health Sciences Building 0200 Tel: (859) 323-4933 ext. 81379 E-mail: mdebeer@uky.edu Curriculum Vita (pdf)

Area of research focuses on HDL metabolism and how HDL impacts the development of atherosclerosis. Specific interests are how HDL size and apoprotein composition influences its interaction with the HDL receptor SR-BI and other scavenger receptors, as well as how inflammation affects HDL composition and metabolism. Studies are performed in cell culture systems or animal models. Adenoviral vectors are often used to express genes of interest in cultured cells or mouse models.

Recent Publications

De Beer, M.C., Durbin, D.M., Cai, L., Jonas, A., de Beer, F.C., van der Westhuyzen, D.R. Apolipoprotein A-I conformation markedly influences HDL interaction with scavenger receptor BI. J.Lipid Res. 2001;42(2):309-315.

De Beer, M.C., Durbin, D.M., Cai, L., Mirocha, N., Jonas, A., Webb, N.R., de Beer, F.C., van der Westhuyzen, D.R. Apolipoprotein A-II modulates the binding and selective lipid uptake of reconstituted HDL by scavenger receptor BI. J. Biol. Chem. 2001;276:15832-15839.

De Beer, M.C.. Zhao. Z., Webb. N.R., van der Westhuyzen, D.R., De Villiers, W.J.S. Lack of a role for macrosialin in oxidized LDL metabolism. Lipid Res. 2003. 44: 674-685.

De Beer, M.C.. Zhao. Z., Webb. N.R., van der Westhuyzen, D.R., De Villiers, W.J.S. Lack of a role for macrosialin in oxidized LDL metabolism. Lipid Res. 2003. 44: 674-685.

De Beer, M.C., Castellani, L.W., Cai, L., Stromberg, A.J., de Beer, F.C., van der Westhuyzen, D.R. ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res. 2004. 45: 706-715.

Other Publications