Patrick DeLuca - Ph.D.

Patrick DeLuca received bachelor's and master's degrees in pharmacy and a Ph.D. in pharmaceutical sciences, all from Temple University. He was an analytical chemist with Smith Kline & French in Philadelphia and a research associate at Temple University prior to accepting a position as a research scientist at CIBA Pharmaceutical Co. in New Jersey. Dr. DeLuca has been associated with the University of Kentucky College of Pharmacy since July 1970, where he is a professor in the Division of Pharmaceutical Sciences. His primary teaching and research responsibilities and interests are in novel drug delivery, formulation and process development of proteins and peptides, and freeze-drying.

Dr. DeLuca is the author or co-author of over 200 articles and book chapters and is the recipient of numerous research awards, including the first AAPS Research Achievement Award in Pharmaceutical Technology and the first AAPS Outstanding Educator Award. He is editor-in-chief of the new online journal, AAPS PharmSciTech, and formerly was chief editor of Pharmaceutical Development and Technology.

Dr. DeLuca also is a Fellow and founding member of AAPS; past president, Fellow and member of the APhA Academy of Pharmaceutical Sciences; a senior Fellow of the Institute for Advanced Biotechnology; and a member of the American Pharmaceutical Association, Controlled Release Society, Parenteral Drug Association, New York Academy of Sciences, American Association of Colleges of Pharmacy, and the American Society of Health-Systems Pharmacists.

Dr. DeLuca's area of graduate study is in drug delivery and formulation. His research and activity are in the following areas: Novel Drug Delivery: The development and evaluation of microparticulate polymeric systems to target drugs. Currently funded projects include: targeted drug delivery and selective pharmacologic activity using biodegradable microspheres and the development and evaluation of microspheres as peptide and protein delivery systems. Formulation and Process Development of Proteins and Peptides: The use of cryoprotectants is being evaluated for the protection and stabilization of proteins during processing and storage. Additionally, matrices are being developed for administering bone-growth agents. Research in Freeze Drying: Having established an international reputation in this area, projects are under way to optimize freeze-drying cycles of pharmaceuticals and proteins through the acceleration of the mass-transfer process.

Selected Honors

• Sullivan Medallion Award, University of Kentucky (2001)
• Outstanding Educator Award, American Association of Pharmaceutical Scientists (2000)
• Editor of Pharm SciTech, an official online journal of the American Association of Pharmaceutical Scientists (2000)
• Editor of Pharmaceutical Development and Technology, an official journal of the American Association of Pharmaceutical Scientists (1996)
• William B. Sturgill Research Award, University of Kentucky (`995)
• Research Achievement Award in Pharmaceutical Technology, American Association of Pharmaceutical Scientists (1988)
• ASHP Research Award with graduate student, PDA Foundation for the Parenteral Sciences, to study the "Effects of Freezing and Drying on Immunoglobulin Conformation" (1986)
• Research Achievement Award from the Parenteral Drug Association in recognition of outstanding contribution to the literature in advancing parenteral technology (1975)
• Co-author and faculty adviser of award-winning papers submitted by graduate students to the Parenteral Drug Association for the years (1972)
• Best paper during the year toward the scientific advancement of industrial pharmaceutics. Recognized by the North Jersey Pharmaceutical Research Discussion Group (1965)
• Lunsford-Richardson Pharm Award for "The Inactivation of Cationic Pharmaceuticals by Nonionic Surface Active Agents" (1960)

Selected Publications/Presentations

• Burton, K.W.; Shameem, M.; Thanoo, B.C.; DeLuca, P.P., "Extended Release Peptide Delivery Systems Through the Use of PLGA Microsphere Combinations," Journal of Biomaterials Science, Polymer Edition, 11(7), 715-729, 2000.
• Ravivarapu, H.B.; Lee, H-Y; DeLuca, P.P., "Enhancing Initial Release of Peptide from PLGA Microspheres by Addition of a Porosigen and Increasing Drug Load," Pharmaceutical Development and Technology, 5(2), 281-290, 2000.
• Ravivarapu, H.B.; Burton, K.; Shameem, M.; DeLuca, P.P., "Polymer and Microsphere Blending to Alter the Release of a Peptide from PLGA Microspheres," European Journal of Pharmaceutics, 50, 263-270, 2000.
• Kostanski, J.W.; Thanoo, B.C.; DeLuca, P.P., "Preparation, Characterization and In Vitro Evaluation of 1- and 4-month Controlled Release Orntide PLA and PLGA Microspheres," Pharmaceutical Development and Technology, 5(4), 585-596, 2000.
• Kostanski, J.W.; DeLuca, P.P., "A Novel In Vitro Release Technique for Peptide Containing Biodegradable Microspheres," PharmSciTech, 1(1) article 4, 2000.
• Kostansi, J.W.; Dani, B.A.; Reynolds, G.A., Bowers, C.Y.; DeLuca, P.P., "Evaluation of Orntide Microspheres in a Rat Animal Model and Correlation to In Vitro Release Profiles," PharmSciTech, 1(4), article 27, 2000.
• Gebrekidan, S.; Woo, B.H.; DeLuca, P.P., "Formulation and In Vitro Transfection Efficiency of Poly (D, L-lactide-co-glycolide) Microspheres Containing Plasmid DNA for Gene Delivery," PharmSciTech, 1(4), article 28, 2000.
• Tsai, T.; Mehta, R.C.; DeLuca, P.P., "Adsorption of Peptides to Poly(d,l-lactide-co-glycolide): 2. Effect of Solution Properties on the Adsorption," International Journal of Pharmaceutics, 127:43-52, 1996.
• Mehta, R.C.; Thanoo, B.C.; DeLuca, P.P., "Peptide Containing Microspheres from Low Molecular Weight and Hydrophilic Poly (d, l-lactide-co-glycolide)," J. of Control. Rel., 41(3), 249-257, 1996.
• Li, M.; Shen, Y.; Burton, K.W.; DeLuca, P.P.; Mehta, R.C.; Baumann, B.D.; Wronski, T.J., "A Comparison of the Skeletal Effects of Intermittent and Continuous Administration of Calcitonin in Ovariectomized Rats," Bone, 18(4), 375-380, 1996.
• Jeyanthi, R.; Thanoo, B.C.; DeLuca, P.P., "Effect of Solvent Removal Technique on the Matrix Characteristics of Polylactide/glycolide Microspheres for Peptide Delivery," J. of Control. Rel., 38(2-3), 235-244, 1996.
• Jeyanthi, R.; Mehtq, R.C.; Thanoo, B.C.; DeLuca, P.P., "Effects of Processing Parameters on the Properties of Peptide Containing PLGA Microspheres," J. of Microencapsulation, 14(2), 163-174, 1997.