John Littleton - Ph.D.

Selected Publications/Presentations

• Littleton JM The future of plant drug discovery. Expert Opinion on Drug Discovery. 2007. 2: 263-283.
• Suttipanta N, Pattanaik S, Gunjan S, Xie CH, Littleton JM, Yuan L. Promoter analysis of the Catharanthus roseus geraniol 10-hydroxylase geneinvolved in terpenoid indole alkaloid biosynthesis. Biochim Biophys Acta. 2007 Feb;1769(2):139-48.
• Mello CF, Rubin MA, Sultana R, Barron S, Littleton JM, Butterfield DA. Difluoromethylornithine decreases long-lasting protein oxidation induced byneonatal ethanol exposure in the hippocampus of adolescent rats.Alcohol Clin Exp Res. 2007 May;31(5):887-94.
• Smith KJ, Self RL, Butler TR, Mullins MM, Ghayoumi L, Holley RC, Littleton JM, Prendergast MA. Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures.Brain Res. 2007 Jul 9;1157:74-80.
• Littleton JM, Barron S, Prendergast M, Nixon SJ. Smoking kills (alcoholics)! shouldn't we do something about it? Alcohol Alcohol. 2007 May-Jun;42(3):167-73.
• Littleton JM Acamprosate: implications of a unique mechanism of action.J Addiction Med 2007 1:115-125
• Farook JM, Morrell DJ, Lewis B, Littleton JM, Barron S. Topiramate (Topamax) reduces conditioned abstinence behaviours andhandling-induced convulsions (HIC) after chronic administration of alcohol inSwiss-Webster MICE. Alcohol Alcohol. 2007 Jul-Aug;42(4):296-300.
• Mulholland PJ, Self RL, Hensley AK, Little HJ, Littleton JM, Prendergast MA. A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or proteinsynthesis.Brain Res. 2006 Apr 12;1082(1):165-72.
• Wilkins LH Jr, Prendergast MA, Blanchard J, Holley RC, Chambers ER, Littleton JM. Potential value of changes in cell markers in organotypic hippocampal culturesassociated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes.Alcohol Clin Exp Res. 2006 Oct;30(10):1768-80.
• Mulholland PJ, Self RL, Stepanyan TD, Little HJ, Littleton JM, Prendergast MA. Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro. Neuroscience. 2005;135(4):1129-39. PMID: 17386069 [PubMed - indexed for MEDLINE]

Website Links

• Tobacco Research