Hsin-Hsiung (Daniel) Tai, Ph.D.

Selected Honors

• University of Kentucky Wethington Award (2004 - 05)
• University of Kentucky Faculty Merit Award (1987 - 89)
• University of Kentucky Research Professorship (1986 - 87)

Selected Publications/Presentations

• WWolf, I., O'Kelly, J., Rubinek, T., Tong, M., Ngyyen, A., Lin, B.T., Tai, H.H., Karlan, B.Y. and Koeffler, H.P. (2006) 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH) Is a Tumor Suppressor of Human Breast Cancer. Cancer Res. 66: 7818-7823.
• Cho, H., Huang, L., Hamza, A., Gao, D., Zhan, C.G. and Tai, H.H. (2006) Role of Glutamine 148 of Human 15-Hydroxyprostaglandin Dehydrogenase in Catalytic Oxidation of Prostaglandin E2. Bioorg. Med. Chem. 14: 6486-6491.
• Tong, M., Ding, Y. and Tai, H.H. (2006) Histone Deacetylase Inhibitors and Transforming Growth Factor-ß Induce 15-Hydroxyprostaglandin Dehydrogenase Expression in Human Lung Adenocarcinoma Cells. Biochem Pharmacol. 72: 701-709.
• Yan, W. and Tai, H.H. (2006) Glycogen Synthase Kinase-3 Phosphorylation, T-Cell factor Signaling Activation and Cell Morphology Change Following Stimulation of Thromboxane Receptor a. J. Pharmacol. Exp. Ther. 317:267- 274.
• Gao, D., Cho, H., Yang, W., Pan, Y., Yang, G.F., Tai, H.H. and Zhan, C.G. (2006) Computational Design of a Human Butyrylcholineesterase Mutant for Accelerating Cocaine Hydrolysis Based on the Transition-State Simulation. Angew. Chem. Int. Edit. 45: 653-657.
• Tai, H.H., Cho, H., Tong, M. and Ding, Y. (2006) NAD+-Linked 15- Hydroxyprostaglandin Dehydrogenase: Structure and Biological Functions. Curr. Pharmaceu. Design 12:955-962.
• Huang, X., Yan, W., Gao, D., Tong, M., Tai, H.H. and Zhan, C.G. (2006) Structural and Functional Characterization of Human Microsomal Prostaglandin E Synthase-1 by Computational Modeling and Site-Directed Mutagenesis. Bioorg. Med. Chem. Chem. 14: 3553-3562.
• Otani, T., Yamaguchi, K., Scherl, E., Du, B., Tai, H.H., Greifer, M., Subbaramaiah, K. and Dannenberg, A.J. (2006) Levels of NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Are Reduced in Inflammatory Bowel Disease. Evidence for Involvement of TNF-a. Am. J. Physiol. 290: G361-G368.
• Yan, W., Ding, Y. and Tai, H.H. (2006) 14-3-3? Interacts with Thromboxane Receptors and Is Involved in the Agonist-Induced Activation of the Extracelluar-Signal-Regulated Kinase. Biochem. Pharmacol. 71: 624-633.
• Tong, M. Ding, Y. and Tai, H.H. (2006) Reciprocal Regulation of Cyclooxygenase-2 and 15-Hydroxyprostaglandin Dehydrogenase Expression in A549 Human Lung Adenocarcinoma Cells. Carcinogenesis 27: 2170-2179.