Greg Elliott

Our research group's interests are in the area of drug design and natural product synthesis. A current theme of the group is development of new drugs and in improving the properties of existing therapies to solve problems in cancer treatment. This effort includes the rational design and synthesis of complex organic molecules as a novel class of multisubstrate inhibitors of target proteins implicated in various cancers. A second area is in the development of new methodology and its application to total synthesis. For this we will utilize a innovative and exciting ring expansion reaction which forms unusual heterocycles. All projects are intended to explore new targets through rational library design and target directed synthesis.

Selected Honors

• Roche Bioscience Fellowship in Synthetic Organic Chemistry (1999-2000)
• Research Experience for Undergraduates University of Wyoming, Laramie, WY (1995)

Selected Publications/Presentations

• Elliott, G. I.; Fuchs, J. R.; Blagg, B, S. J.; Ishikawa, H.; Yuan, Z-Q.; Tao, H.; Boger, D. L. Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles J. Am. Chem. Soc. 2006, 10589-10595.
• Ishikawa, H.; Elliott, G. I.; Velcicky, J.; Choi, Y.; Boger, D. L. Total Synthesis of (-)- and ent-(+)-Vindoline and Related Alkaloids J. Am. Chem. Soc. 2006, 10596-10612.
• Elliott, G. I.; Velcicky, J.; Ishikawa, H.; Li, Y.; Boger, D. L. Total Synthesis of (-)- and ent-(+)-Vindorosine: Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition of 1,3,4-Oxadiazoles Angew. Chem,. Int. Ed. 2006, 45, 620-622.
• Choi, Y.; Ishikawa, H.; Velcicky, J.; Elliott, G. I.; Miller, M. M.; Boger, D. L. Total Synthesis of (-)- and ent-(+)-Vindoline Org. Lett. 2005, 7, 4539-4542.
• Malerich, J. P.; Maimone, T. J.; Elliott, G. I.; Trauner, D. Biomimetic Synthesis of Antimalarial Naphthoquinones J. Am. Chem. Soc. 2005, 127, 6276-6283.
• Elliott, G. I.; Boger, D. L. 6,6-Dimethyl-4,8-dioxaspiro[2.5]oct-1-ene Electronic Encyclopedia of Reagents forOrganic Synthesis; Paquette, L. A., Ed.; John Wiley & Sons: Chichester 2004.
• Elliott, G. I.; Boger, D. L. Cyclopropene, 3,3-dimethoxy Electronic Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed.; John Wiley & Sons: Chichester 2004.
• Wilkie, G.; Elliott, G. I.; Blagg, B. S. J.; Wolkenberg, S. E.; Soenen, D. R; Miller, M. M.; Pollack, S.; Boger, D. L. Intramolecular Diels-Alder and Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles. J. Am. Chem. Soc. 2002, 124, 11292-11294.
• Cappuccio, J. A.; Ayala, I.; Elliott, G. I.; Szundi, I.; Lewis, J.; Konopelski, J. P; Barry, B. A.; Einarsdottir, O Modeling the Active Site of Cytochrome c Oxidase: Characterization of a Cross-linked Histidine-Phenol J. Am. Chem. Soc. 2002, 124, 1750-1760.