| Heart Rate |
Contractile Force |
TPR | Blood Pressure |
|
| Isoproterenol | Increases due to activation of beta1 receptors in SA and AV nodes | Increases due to activation of beta 1 receptors on myocardial cells. | Decreases due to activation of beta 2 receptors | cardiac output x total peripheral vascular resistance |
| Norepinephrine | Decrease due to reflex increase in vagal tone on SA and AV nodes | Increases due to effects on beta1-ARs on myocardial cells | Increases due to activation of alpha1-ARs on vascular smooth muscle cells | Increases due to effects on total peripheral vascular resistance |
| Low Doses of Epi | Increases due to beta1-ARs on SA and AV nodal tissues | Increases due to activation of beta1-ARs on myocardial cells | Decreases due to preferential activation of beta2-ARs, at these doses there would be little activation of alpha1-ARs | Similar to isoproterenol; the net effect will be the activity seen on cardiac output and total peripheral vascular resistance |
| High Doses of Epi | Similar to the effects of norepinepherine | Increases due to beta1-ARs on myocardial cells | Increases due to activation of alpha1-ARs on vascular smooth muscle cells. Notice how at this dose the predominate effect is via the alpha1-ARs not the beta2-AR mediated decrease in total peripheral vascular resistance. | Increases due to activation of alpha1-ARs on vascular smooth muscle cells |