Hollie Swanson, Ph.D.
Professor
Purdue University, 1991
Office: MN-322 Chandler Medical Center (0298)
Lab: MS-374; (859) 323-1170 or (895) 323-2881
Tel: (859) 323-1463
Research Summary
My training encompasses the fields of Biochemistry, Molecular Biology, Pharmacology and Environmental Toxicology and my expertise has focused on nuclear receptors and drug metabolism. My research efforts during the past 22 years have focused on various aspects of the AHR (aryl hydrocarbon receptor) signaling pathway. As an NIH-funded PI in my own laboratory, I have utilized 2,3,7,8 tetrachloro-dibenzo-p-dioxin (TCDD) as a model environmental contaminant that activates the AHR, to understand how environmental exposures alter cell fate decisions relevant to chronic human disease states, such as cancer. My laboratory, either alone or in successful collaborations with other researchers, has also reported on interactions between the AHR and other signaling pathways, such as that of the estrogen receptor, Akt and TGFβ. Our most recent work (submitted) has demonstrated that in an in vivo model of acute injury, exposure to TCDD alters proper tissue repair and regeneration and enhances the population of macrophages within the wounded tissue. Inflammatory bowel diseases involve epithelial restitution after injury, appropriate homeostasis of epithelial cells (apoptosis, proliferation and differentiation), proinflammatory responses, cell-matrix adhesion, signaling between epithelial and immune cells and barrier function. Thus, we propose to build on our previous work using a relevant animal model of Crohn’s disease and human samples to establish that the appropriate molecular events that occur in the human patient. Additional ongoing work includes the development of novel AHR antagonists. We hypothesize that these antagonists will prove to be useful therapies for the treatment of Crohn’s and other human disease states.
Selected Publications
Arsenescu, V., Arsenescu, R.I., King, V., Swanson, H.I., and Cassis, L.A. (2008)
Exposure to polychlorinated biphenyl 77 increases adipocyte differentiation and proinflammatory adipokines, contributing to the development of obesity and obesity-associated atherosclerosis.
Environ. Hlth. Persp. 116, 761-768.
Ray, S and Swanson, H.I. (2009)
Role of the aryl hydrocarbon receptor in senescence, apoptosis and tumor promotion.
BioChemical Pharm. (Invited Review) 77, 681-688.
Swanson, H.I., Njar, V.C.O., Yu, Z., Castro, D.J., Gonzalez, F.J., Williams, D.E., Kong, A.T., Waxman, D.J. and Scott, E.E. (2010)
Targeting drug metabolizing enzymes for effective chemoprevention.
Drug Metabolism Disposition. 38, 539-544.
Cyrus, K., Wehenkel, M., Choi, E.Y-., Lee, H., Swanson, H and Kim, K-B.
Jostling for position: optimizing linker location in the design of estrogen receptor-targeting Protacs.
ChemMedChem (In Press)
Cyrus, K. Wehenkel M. Choi, E.Y-., Swanson, H. and Kim, K-B.
Two-Headed PROTAC: An effective tool for targeted protein degradation.
Chembiochem (2010) (Epub May 28) PMID: 20572272
Arsenescu, R.I., Arsenescu, V., Zhong, J., Nasser, M., Melinte, R., Dingle, R.W.C., Swanson, H.I and Villiers, W. J.S.
Role of the xenobiotic receptor in inflammatory bowel diseases.
Inflammatory Bowel Diseases (In Press).
Helton, W.B., Valentino, J., Choi, E.-Y., Gairola, C.G. and Swanson, H.I.
Apigenin and kaempferol effects in oral cancer FaDu cells.
(Submitted).
Moirangthem, V., Katz, W.S., Su, W., Choi, E.Y., Dingle, R.W., Zeigler, G.M., Everson, W.V., Jennings, C.D., Gong, M. and Swanson, H.I.
Impact of 2,3,7,8 tetrachlorodibenzo-p-dioxin on cutaneous wound healing.
(Submitted).
Ray, S and Swanson, H.I.
Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a.
J. Biol. Chem (In Press).
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