Philip W. Landfield, Ph.D.
Professor and Chair;
University of California, Irvine, 1971.
Office: MS-307 Chandler Medical Center (0298)
Lab: MS-310; (859) 323-6124 or (859) 323-6134
Tel: (859) 323-5454
Research activities are focused on analyses of basic cellular and molecular mechanisms of brain aging, neurodegeneration and brain memory processes; with particular emphasis on studies of neuronal calcium channels,and the effects of hormones and drugs on brain cells. Research tools include single-channel patch clamp recording of ion channels, gene microarrays, molecular biology, single cell PCR and rapid imaging of calcium fluxes with confocal laser scanning microscopy.
Selected Publications
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Landfield PW, Blalock EM, Chen KC, Porter NM (2007)
A New Glucocorticoid Hypothesis of Brain Aging: Implications for Alzheimer’s Disease.
Current Alzheimer’s Research 4: 205-212
Rowe* WB, Blalock* EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW (2007)
Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats.
J Neurosci 27: 3098-3110
Gant JC, Sama MM, Landfield PW, Thibault O. (2006)
Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.
J Neurosci 26(13):3482-90
Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD. (2005)
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.
J Neurosci 25(18):4649-58
Blalock EM, Geddes JW, Chen KC, Porter NM, Markesbery WR, Landfield PW. (2004)
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.
PNAS 101(7):2173-8
Toescu EC, Verkhratsky A, Landfield PW. (2004)
Ca2+ regulation and gene expression in normal brain aging.
Trends Neurosci 27(10):614-20
Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW. (2003)
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.
J Neurosci 23(9):3807-19
Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ. (2003)
Statistical implications of pooling RNA samples for microarray experiments.
BMC Bioinformatics 4:26
Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM. (2002)
Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity.
Neuroscience 112:183-194.
Norris CM, Blalock EM, Chen KC, Porter NM, Landfield PW. (2002)
Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.
Neuroscience.110:213-225.
Thibault O, Hadley R, Landfield PW. (2001)
Elevated postsynaptic [Ca2+]i and L-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity.
J Neurosci 21:9744-9756.
Blalock EM, Chen KC, Vanaman TC, Landfield PW, Slevin JT. (2001)
Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices.
Epilepsy Res. 43:211-226.
Brewer L, Thibault V, Chen K-C, Langub C, Landfield PW and Porter NM. (2001)
Vitamin D hormone confers neuroprotection in parallel with down-regulation of L-type calcium channel expression in hippocampal neurons.
J Neurosci 21(1)98-108.
Blalock EM, Chen K-C, Wooton-Kee R, Landfield PW. (2000)
Gene expression profiling in largely-intact single neurons from hippocampal zipper slices of adult and aged animals.
Soc Neurosci Abs 26: 533.
Chen K-C, Blalock EM, Thibault O, Kaminker P and Landfield PW. (2001)
Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices.
PNAS 97(8):4357-4362.
Blalock EM, Porter NM, Landfield PW. (1999)
Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.
J Neurosci 19:8674-84.
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