Susan D. Kraner, Ph.D.
Assistant Professor;
University of Pennsylvania, 1989
Office: MS-313 Chandler Medical Center (0298)
Lab: MS-306; (859) 323-4875
Tel: (859) 323-1996
Research Interests
My research focuses on regulation of ion channel gene expression. Regulation of ion channel genes modulates the electrical excitability of nerve, muscle and heart cells and, in the case of Ca++ channels, results in changes in Ca++-driven processes such as changes in learning and memory and changes in gene expression. My overall goal is to understand how changes in Na+ channel gene expression contribute to such processes as the development, synapse-formation and denervation/regeneration of muscle and how changes in Ca++ channel gene expression contribute to age-related changes in learning and memory. My long-term goal is to manipulate ion channel gene expression for the treatment of disease and age-related dysfunctions.
Selected Publications
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Thompson AL, Filatov G, Chen C, Porter I, Li Y, Rich MM, and Kraner SD.
A selective role for MRF4 in innervated adult skeletal muscle: NaV 1.4 Na+ channel expression is reduced in MRF4-null mice,
Gene Expression 12: 289-303, 2005.
Blalock EM, Chen K-C, Stromberg AJ, Norris CM, Kadish I, Kraner SD, Porter NM, and Landfield PW.
Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's Disease: Statistical reliability and functional correlation,
Aging Research Reviews 4: 481-512, 2005.
Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, and Kraner SD.
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models,
Journal Neurosci. 25: 4649-4658, 2005.
Kraner SD, Rich MM, Sholl MA, Zhou HY, Zorc C, Kallen RG and Barchi RL. (1999)
Interaction Between the Skeletal Muscle Type 1 Na+ Channel Promoter E box and an Upstream Repressor Element. Release of Repression by Myogenin.
Journal of Biological Chemistry. 274:8129- 8136.
Gonzalez M, Ruggiero FP, Chang Q, Shi Y-J, Rich MM, Kraner S and Balice-Gordon RJ. (1999)
Disruption of TrkB-mediated signaling induces disassembly of postsynpatic receptor clusters at neuromuscular junctions.
Neuron 24:567-583.
Rich MM, Kraner SD and Barchi RL. (1999)
Altered gene expression in an animal model of acute quadripelgic myopathy.
Neurobiology of Disease 6: 515-522.
Kraner SD, Rich MM, Kallen RG and Barchi RL. (1998)
Two E-boxes are the focal point of muscle-specific skeletal muscle type 1 Na+ channel gene expression.
Journal of Biological Chemistry. 273:11327-34.
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