Michael W. Kilgore, Ph.D.
Associate Professor
Health Sciences Center, Texas Tech University, 1990
Office: MN-354 Chandler Medical Center (0298)
Lab: MN-344; (859) 323-2604
Tel: (859) 323-1821
The Kilgore Lab Website
Current Projects
Recent advances in our understanding of gene regulation and function and the decoding of the human genome have presented those of us in medical research with a breathtaking opportunity to study the causes and cures of devastating disease such as cancer. My lab is focused on using these tools to address the cause of the rising rates of breast cancer and to examine the role of endogenous hormones such as the estrogens and environmental exposure in its etiology. These studies include the use a molecular approach to study hormone action and define dietary compounds that alter the risks of breast and other types of cancer. Recent findings in our lab demonstrate that like the estrogen receptor, the gamma form of the peroxisome proliferator-activated receptor (PPAR) may represent a therapeutic target for the prevention or treatment of several types of cancer including breast, prostate and lung cancer. We are using state-of-the art approaches including genechip technology, real-time PCR and other molecular tools to asses both basic mechanisms of hormone action and explore possible therapeutic approaches in the treatment of these tumors. Furthermore, we have now shown that like other hormones, fatty acids too bind receptor and mediate target gene expression which may represent a molecular link between diet and cancer including breast cancer.
Selected Publications (a complete publication list can be found at Dr. Kilgore's Website)
DR Talbert, CD Allred, YY Zaytseva and MW Kilgore
Transactivation of ERα by Rosiglitazone induces proliferation in breast cancer cells.
(epub ahead of print)
PMID: 17453334
Pancani T, Phelps JT, Searcy JL, Kilgore MW, Porter NM, and Thibault O
Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-γ agonists in cultured hippocampal neurons. J. Neurochem., 109:1800-1811.
Zaytseva YY, Wang X, Southard RC, Wallis NK, and Kilgore MW
Down-regulation of PPARγ1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells.
Molecular Cancer 2008, 7:90 (5 December 2008) [epub ahead of print]
Allred CD, Talbert DR, Southard RC, Wang X, and Kilgore MW
PPARgamma1 as a molecular target of eicosapentaenoic acid in human colon cancer (HT-29) cells.
J Nutrition. 2008 Feb;138(2):250 - 6
PMID: 18203887
CD Allred and MW Kilgore.
The increased expression of PPARγ1 in human breast cancer.
Mol Cell Endocrinol. 2005 May 12;235(1-2):21-29.
PMID: 15866424
Wang X, Southard RC, Kilgore MW.
The increased expression of peroxisome proliferator-activated receptor-gamma1 in human breast cancer is mediated by selective promoter usage.
Cancer Res. 2004 Aug 15;64(16):5592-6.
PMID: 15313896
Jones GB, Wright JM, Hynd G, Wyatt JK, Warner PM, Huber RS, Li A,Kilgore MW, Sticca RP, Pollenz RS.
Oxa-enediynes: probing the electronic and stereoelectronic contributions to the Bergman cycloaromatization.
Journal of Organic Chemistry. 2002 Aug 9;67(16):5727-32.
Wang X, Kilgore MW.
Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells.
Mol Cell Endocrinol. 2002 Aug 30;194(1-2):123-33.
PMID: 12242035
Jones GB, Hynd G, Wright JM, Purohit A, Plourde GW 2nd, Huber RS, Mathews JE, Li A, Kilgore MW, Bubley GJ, Yancisin M, Brown MA.
Target-directed enediynes: designed estramycins.
Journal of Organic Chemistry 2001 Jun 1;66(11):3688-95.
Thoennes SR, Tate PL, Price TM, Kilgore MW.
Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells.
Mol Cell Endocrinol. 2000 Feb 25;160(1-2):67-73.
PMID: 10715540
TM Price, SN O'Brien, BH Welter, R George, J Anandjiwala and MW Kilgore.
Estrogen Regulation of adipose tissue lipoprotein lipase - Possible mechanism of body fat distribution.
Am J Obstet Gynecol. 1998 Jan;178(1 Pt 1):101-7.
PMID: 9465811
MW Kilgore, PL Tate, S Rai, E Sengoku and TM Price.
MCF-7 and T47D Human Breast Cancer Cells Contain a Functional Peroxisomal Response.
Molecular and Cellular Endocrinology. 1997 129:229-235.
PMID: 9202406
Additional Publications linked at NCBI's PubMed
Warning Some websites linked on this page for the convenience of users are not managed by the University of Kentucky. The university does not review, control or take responsibility for the contents of those sites.
Disclaimer: Journal articles can be downloaded from this site for personal use only and may not be duplicated or distributed for commercial reasons, without written authorization from the Journal, the copyright holder.