Kuey-Chu Chen, Ph.D.
Associate Research Professor and Director UK Microarray Core Facility
University of California, Davis, 1983.
Office: HSRB-154, Health Sciences Research Building (0305)
Lab: MN-305 Chandler Medical Center (0298), (859) 323-3608;
HSRB-156 Health Sciences Research Building, (859) 323-6979
Tel: (859) 323-6241
Research activities involve studies of gene expression in brain in relation to aging and hormone regulation. Research approaches emphasize the use of molecular biology, particularly quantitative analysis of messenger RNA in the brain, to investigate the expression of certain genes, including hormone receptors, calcium channels and various second messengers. Several new cutting edge approaches using real-time PCR and DNA microarray analyses are presently being established in the lab.
Selected Publications
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Landfield PW, Blalock EM, Chen KC, Porter NM (2007)
A New Glucocorticoid Hypothesis of Brain Aging: Implications for Alzheimer’s Disease.
Current Alzheimer’s Research 4: 205-212
Rowe* WB, Blalock* EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW (2007)
Hippocampal Expression Analyses Reveal Selective Association of Immediate-Early, Neuroenergetic, and Myelinogenic Pathways with Cognitive Impairment in Aged Rats.
J Neurosci 27: 3098-3110
Peng X, Wood CL, Blalock EM, Chen KC, Landfield PW, Stromberg AJ. (2003)
Statistical implications of pooling RNA samples for microarray experiments.
BMC Bioinformatics. 4:26.
Blalock EM, Chen KC, Sharrow K, Herman JP, Porter NM, Foster TC, Landfield PW. (2003)
Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment.
J Neurosci. 23:3807-3819.
Norris CM, Blalock EM, Chen K-C, Porter NM, Landfield PW. (2002)
Calcineurin enhances L-type Ca(2+) channel activity in hippocampal neurons: increased effect with age in culture.
Neuroscience.110:213-225.
Blalock EM, Chen K-C, Vanaman TC, Landfield PW, Slevin JT. (2001)
Epilepsy-induced decrease of L-type Ca2+ channel activity and coordinate regulation of subunit mRNA in single neurons of rat hippocampal 'zipper' slices.
Epilepsy Res. 43:211-226.
Brewer L, Thibault V, Chen K-C, Langub C, Landfield PW and Porter NM. (2001)
Vitamin D hormone confers neuroprotection in parallel with down-regulation of L-type calcium channel expression in hippocampal neurons.
J Neurosci 21(1)98-108.
Blalock EM, Chen K-C, Landfield PW and Slevin J. (2001)
Kindling chronically depresses L-type Ca2+ current and a1D mRNA in hippocampal CA1 neurons.
Epilepsy Res 43:211-226.
Chen K-C, Blalock EM, Thibault O, Kaminker P and Landfield PW. (2000)
Expression of a1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices.
PNAS 97(8):4357-4362.
Blalock EM, Chen K-C, Wooton-Kee R and Landfield PW. (2000)
Gene expression profiling in largely-intact single neurons from hippocampal zipper slices of adult and aged animals.
Soc Neurosci Abs 26: 533, 2000.
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