Pathology & Laboratory Medicine

Craig Horbinski,  M.D., Ph.D.

Assistant Professor

E-mail: cho225@email.uky.edu
Telephone:   (859) 257-1937
Fax:   (859) 257-3551
Pager:   (859) 330-6283

Campus Address:  MS-112, 800 Rose Street, Lexington KY 40536

Primary research interests

1. The role that mutant isocitrate dehydrogenase 1 (IDH1) plays in gliomagenesis, including:
1. Transfection of R132H mutant IDH1 into glial progenitor cells cultured from donated postmortem human brain tissue
2. Assays on cellular proliferation, migration, oxidation-reduction status, and response to chemotherapy and radiation
2. Survivorship prediction modeling in glioblastomas via bioinformatics data mining of The Cancer Genome Atlas, in collaboration with the Bioinformatics Department at the University of Pittsburgh. 
1.  Such modeling will then be used to identify signaling pathways that impact survival in patients with glioblastoma.

Other initiatives

1. Establishment of a brain tumor bank at the University of Kentucky that will consist of snap-frozen brain tumors matched with clinical data, including survival.  Over time, enough cases will accumulate such that powerful institutional retrospective studies on tumor biology and biomarkers will be possible.  First priority will be given to studies within the University of Kentucky, but the tissue will also be available for larger multi-institutional endeavors.
2. The development and application of telemedicine to rural parts of Kentucky, in particular the development of telepathology for intraoperative consultations at rural sites.  Surgeons working at remote sites would have access to expert subspecialty pathologist guidance during surgery, thus improving patient outcomes.