- Salvatore MF, Fisher B,
Surgener SP, Gerhardt GA, and Roualut T. Neurochemical investigations of
dopamine neural systems in iron-regulatory protein 2 (IRP-2) knockout mice.
Mol Brain Res 139:341-347, 2005. PMID: 16051392
- Gash DM, Zhang Z, Ai Y,
Grondin R, Coffey R, and Gerhardt GA. Trophic factor distribution
predicts functional recovery in parkinsonian monkeys. Ann Neurol
58(2):224-33, 2005. PMID: 16049934
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Young B, Gash D, Gerhardt GA, Hutchinson M. GDNF in treatment of
Parkinson's disease: response to editorial. The Lancet Neurology, 5(3):
202-203, 2006. PMID: 16488374
- Slevin JT, Gerhardt GA,
Smith CD, Gash DM, and Young AB. Reply: GDNF poses troubling questions
for doctors, drug maker. Ann Neurol. 59(6):989-990, 2006. PMID:16711657
- Slevin JT, Gash DM, Smith
CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, and Young AB.
Unilateral intraputaminal glial cell line-derived neurotrophic factor in
patients with Parkinson disease: response to 1 year each of treatment and
withdrawal. J Neurosurg. 106(4):614-20, 2007. PMID: 17432712
- Salvatore MF, Ai Y,
Fischer B, Zhang AM, Grondin RC, Zhang Z, Gerhardt GA and Gash DM. Point
source concentration of GDNF may explain failure of Phase II clinical trial.
Exp Neurol 202(2):497-505, 2006. (Epub 2006 Sep. 7) PMID: 16962582
- Zhang Z, Andersen AH, Ai
Y, Loveland A, Hardy PA, Gerhardt GA and Gash DM. Assessing nigrostriatal
dysfunctions by pharmacological MRI in parkinsonian rhesus macaques.
Neuroimage 33(2):636-43, 2006. (Epub 2006 Sep. 1) PMID: 16949305
- Cass, WA, Grondin R,
Andersen AH, Zhang Z, Hardy PA, Hussey-Andersen LK, Rayens WS, Gerhardt GA
and Gash DM. Iron accumulation in the striatum predicts aging-related
decline in motor function in rhesus monkeys. Neurobiology of Aging
28(2):258-71, 2007. PMID: 16442671
- Stanford JA, Salvatore MF,
Joyce BM, Zhang H, Gash DM and Gerhardt GA. Bilateral effects of
unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related
striatal neurons in aged F344 rats. Neurobio Aging 28:156-165, 2007. (Epub
2005 Nov 28) PMID: 16314001
- Smith CD, Walton A, Slevin
JT, Gerhardt GA, Umberger G, Smoot K, Schulze E and Gash DM. Validation
studies of the human motor activities panel for Hand/Arm Performance. J
Neurosci Meth 165:287-296, 2007. (Epub 2007 Jun 22) PMC2074932, NIHMS29682
- Quintero JE, Day BK, Zhang
Z, Grondin R, Stephens ML, Huettl P, Pomerleau F, Gash DM, Gerhardt GA.
Rapid amperometric measures of age-related changes in glutamate regulation
in cortex of rhesus monkeys. Exp Neurol Dec; 208(2):238-246, 2007. (Epub
2007 Aug 22) PMID: 17927982
- Gash DM, Rutland K, Hudson
JL, Sullivan PG, Bing G, Cass WA, Pandya JD, Liu M, Choi D-Y, Hunter RL,
Gerhardt GA, Smith CD, Slevin JT and Prince TS. Trichloroethylene:
Parkinsonism and Complex I Mitochondrial Neurotoxicity. Ann Neurol Feb;
63(2):184-92, 2008. PMID: 18157908
- Xin T. Ai Y, Gerhardt GA,
Gash and Zhang Z. Globus pallidus plays a critical role in neurotrophic
factor induced functional improvements in hemiparkinsonian monkeys. Biochem
Biophys Res Comm Biochem Biophys Res Commun. Jun 6;370(3):434-9, 2008. (Epub
2008 Mar 31) PMCID: PMC2682325
- Grondin R, Zhang Z, Ai Y,
Ding F, Walton AA, Surgener SP, Gerhardt GA and Gash DM. Intraputamenal
infusion of exogenous neuturin protein restores motor and dopaminergic
function in the globus pallidus of MPTP-lesioned rhesus monkeys. Cell
Transplantation 17(4):373-81, 2008. PMCID: PMC2680490
- Ding F, Luan L, Ai Y,
Walton A, Gerhardt GA, Gash DM, Grondin R and Zhang Z. Development of a
stable, early stage unilateral model of Parkinson's disease in middle-aged
rhesus monkeys. Exp Neuron 212(2):431-9, 2008. [Epub ahead of print] PMCID:
PMC2527750
- Zaman V, Boger HA,
Granholm A-C, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ and
Middaugh LD. The nigrostriatal dopamine system of aging GFR-1
heterozygous mice: neurochemistry, morphology and behavior. Eur J Neurosci
28(8):1557-68, 2008. PMC2704551, NIHMS105188
- Lundblad M, af Bjerkén S,
Cenci MA, Pomerleau F, Gerhardt GA and Strömberg I. Chronic intermittent
L-DOPA treatment induces changes in dopamine release. J Neurochem
108(4):998-1008, 2009. PMID: 19196428
- Stephens, ML, Pomerleau F,
Huettl P, Gerhardt GA and Zhang Z. Real-time glutamate measurements in
the putamen of awake rhesus monkeys using an enzyme-based human
microelectrode array prototype. J Neuro Meth, 185(2):264:72, 2010. Epub 2009
Oct 20. PMCID: PMC2815042, NIHMS153577
- Bradley LH, Fuqua J,
Richard A, Turchan-Cholewo J, Ai, Y, Kelps KA, Glass JD, He X, Zhang Z,
Grondin R, Littrell OM, Huettl P, Pomerleau F, Gash DM and Gerhardt GA.
Dopamine neuron stimulating actions of a GDNF propeptide. PLoS One Biology
5(3):e9752, 2010. PMCID: PMC2841203.
- Zhang, Z, Fan X, Grondin
R, Edwards R, Forman E, Moorehead J and Gerhardt GA. Electroacupuncture
and Electromyographic Recordings in Normal and Parkinsonian Rhesus Monkeys.
J. Neurosci. Meth., in press, 2010.
- Unilateral Intraputamenal GDNF improves bilateral motor functions in patients with
Parkinson’s disease.
Slevin
JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB. J Neurosurg 102:216-222, 2005.
- In vivo
electrochemical studies of d-amphetamine and d,l-amphetamine-induced dopamine
release in the rat striatum and nucleus accumbens core.
Glaser
PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA. Psychopharmacology (in
press), 2005.
- Neurodegenerative alterations in the
nigrostriatal system of trkB hypomorphic mice.
Zaman
V, Nelson ME, Gerhardt GA and Rohrer B. Exp. Neurol. 190(2):337-46,
2004.
- Aged related changes in the dynamics of potassium-evoked l-glutamate release
in the striatum of Fischer 344 rats.
Nickell
J, Pomerleau F, Allen J and
Gerhardt
GA.
J Neural Transm. 112(1):87-96, 2004.
- Caloric
restriction increases GDNF levels and attenuates neurochemical and behavioral
deficits in a primate model of Parkinson’s disease.
Maswood
N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Yi A, Roth
GS, Lane MA, Carson R, Cohen RM, Mouton PM, Mattson MP, Ingram DK. PNAS,
101(52):18171-18176, 2004.
- Beneficial effects of intraventricularly
administered BMP-7 following a striatal 6-hydroxydopamine lesion.
Zuch
CL, David D, Ujhelyi L, Hudson JL,
Gerhardt
GA,
Kaplan PL and Bickford PC. Brain Res
1010:10-16, 2004.
- Striatal GDNF administration increases tyrosine
hydroxylase phosphorylation in the rat striatum and substantia nigra.
Salvatore MF, Zhang J-L, Large DM,
Wilson PE, Gash CR, Thomas TD, Haycock, JW, Bing G, Stanford
JA, Gash DM and Gerhardt GA. J
Neurochem 90(1):245-254, 2004.
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Aged F344 rats exhibit altered
electrophysiological activity in locomotor-unrelated but not locomotor-related
striatal neurons.
Stanford JA and Gerhardt GA. Neurobio Aging 25:509-515, 2004.
-
Prenatal cocaine exposure alters potassium-evoked
dopamine research dynamics in rat striatum.
Salvatore, MF, Hudspeth O, Arnold LE, Wilson PE, Stanford JA, Mactutus CF,
Booze RM and Gerhardt GA. Neuroscience 123:481-490, 2003.
- Differential effects of post-implantation
time on potassium- versus d-amphetamine-evoked DA overflow in the striatum of
F344 rats. Purdom
MS, Stanford JA and Gerhardt GA. Neurosci Ltrs, 348(2):97-100, 2003.
- Microdialysis studies of
d-amphetamine stimuli on striatal dopamine overflow in young versus aged F344
rats: effects of stimulus concentration and order of administration.
Purdom
MS, Stanford JA, Currier TD and Gerhardt GA. Brain Res, 979:203-209, 2003.
-
Decreased plasma membrane
expression of striatal dopamine transporter in aging.
Salvatore MF, Apparsundaram S, and Gerhardt GA. Neurobio Aging,
24:1147-1154, 2003.
- Chloral hydrate and ethanol, but not
urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of freely-moving rats.
Sabeti
J, Gerhardt GA and Zahniser NR. Neurosci Lett
343(1):9-12, 2003.
- Intraputamenal
infusion of GDNF in aged rhesus monkeys: distribution and dopaminergic
effects. Yi A,
Markesbery W, Zhang Z, Grondin E, Gerhardt GA, and Gash, DM. J Comp Neurol 23;461(2):250-61, 2003.
- Individual differences in cocaine-induced locomotor sensitization in rats are associated with initial locomotor
responsiveness to cocaine and differential inhibition of dopamine clearance in
nucleus accumbens by cocaine.
Sabeti
J, Gerhardt GA and Zahniser NR. J Pharm Exp Ther. 305(1):180-90, 2003.
- The noradrenergic system of aged GDNF
heterozygous mice.
Zaman
V, Li Z, Middaugh L, Ramamoorth S, Rohrer B, Nelson ME, Tomac AC, Hoffer BJ,
Gerhardt GA and Granholm A-Ch. Cell Trans 12(3):291-303, 2003.
- Dopaminergic Modulation of the P50 Auditory
Evoked Potential in a Computer Model of the CA3 Region of the Hippocampus:
Its Relationship to Sensory Gating in Schizophrenia.
Moxon,
K.A., Gerhardt GA, Adler, L.E. Biol Cybern
88(4):265-75, 2003.
- Glial cell
line-derived neurotrophic factor increases stimulus-evoked dopamine release
and motor speed in aged rhesus monkeys.
Grondin
R, Cass WA, Zhang Z, Stanford JA, Gash DM and Gerhardt, GA. J Neurosci 23(5):1974-1980, 2003.
-
Differences in spontaneous motor activity and orolingual motor function
between young vs. aged Fischer 344 rats: Relationships with nigrostriatal
neurochemical measures.
Stanford JA, Vorontsova E, Surgener SP, Gerhardt GA, and Fowler SC.
Neurobio Aging, 24(2):259-66, 2003.
- Quantitative analysis of striatal
clearance of exogenous dopamine, recorded by chronoamperometry in the
freely-moving rat.Sabeti
J, Adams CE, Gerhardt GA, and Zahniser, NR. J Neurosci Meth 121(1):41-52, 2002.
- Acute cocaine differentially alters
accumbens and striatal dopamine clearance in low and high cocaine locomotor
responders: behavioral and electrochemical recordings in freely-moving rats.Sabeti
J, Gerhardt GA, and Zahniser, NR. JPET 302(3):1201-11, 2002..
-
Chronic, controlled
striatal delivery of GDNF promotes nigrostriatal dopaminergic regeneration and
behavioral recovery in parkinsonian monkeys. Grondin, R., Zhang, Z., Yi, A., Maswood, N., Cass, W.A., Andersen, A.H.,
Elsberry, D.D., Klein, M.C., Gerhardt GA, and Gash, D.M. Brain 125(10):2191-2201, 2002.
- Effects of chronic intraputamenal infusion of Glial cell line-derived
neurotrophic factor (GDNF) in aged rhesus monkeys.
Maswood
N, Grondin R, Zhang Z, Stanford JA, Surgener SP, Gash DM, and Gerhardt GA.
Neurobio Aging 23(5):881,
2002.
-
Adeno
associated viral delivery of GDNF promotes recovery of dopaminergic phenotype
following a unilateral 6-hydroxydopamine lesion.
McGrath
J, Lintz E., Hoffer BJ, Gerhardt GA, Quintero EM, and Granholm A-C. Cell Trans, 11(3):215-27,
2002.
- Nicotinic acetylcholine receptors interact with
dopamine in induction of striatal long-term depression.
Partridge JG, Apparsundaram, S,
Gerhardt
GA,
Ronesi J and Lovinger DM. J Neurosci
22(7):2542-2549, 2002.
-
Changes in somatodendritic
but not terminal dopamine regulation in aged rhesus monkeys.Gerhardt GA, Cass WA, Yi A, Zhang, Z and Gash, DM. J Neurochem
80:168-177, 2002.
- Aged F344 Rats Exhibit an Increased Proportion of Dopamine Agonist-Excited
Striatal Neurons.Stanford, J.A., Gash, C.R., and
Gerhardt
GA.
Neurobiology of Aging 23(2):263-270, 2002.
- Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail.Helt,
C.E., Hoernig, G.R., Albeck, D.S.,
Gerhardt
GA,
Ickes, B., Reyland, M.E., Quissell, D.O., Stromberg, I., Granholm, A.-C.
Exp
Neurol 170(2):258-69, 2001.
-
Effects of age and GDNF on noradrenergic innervation of the hippocampal:
Studies from intraocular grafts. Granholm, A-Ch, Helt, C., Srivastava, N., Backman, C., and Gerhardt GA. Microsc Res Tech 54(5):298-308, 2001.
-
Age-related changes in striatal function of
freely moving F344 rats. Stanford, JA and Gerhardt GA. Neurobiol Aging 22(4):659-69, 2001.
-
Nomifensine
reveals age-related changes in K+-evoked striatal DA overflow in F344 rats. Stanford, J.A., Currier, T.D., Purdom, M.S., and Gerhardt GA. Neurobiol Aging, 22(3):495-502, 2001.
- Intranigral Transplantation of Solid Tissue
Ventral Mesencephalon or Striatal Grafts Induces Behavioral Recovery in
6-OHDA-Lesioned Rats.
Palmer,
M.R., Granholm, A.-C., van Horne, C.G., Giardina, K.E., Fruend, R.K.,
Moorhead, J.W., and Gerhardt GA. Brain Res 890(1):86-99, 2001.
- Motor slowing and Parkinsonian Signs in Aging Rhesus Monkeys
Mirror Human Aging.
Zhang,
Z., Andersen, A., Smith, C., Grondin, R.,
Gerhardt
GA,
and Gash, D. J Gerontology: Biological Sciences 55A(10): B473-B480,
2000.
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Dopaminergic therapy
improves upper limb motor performance in aged rhesus monkeys. Grondin, R., Zhang, Z, Gerhardt GA and Gash D.M. Ann of Neurol
48(2): 250-253, 2000.
-
Glial Cell Line-Derived Neurotrophic
Factor is Essential for Postnatal Survival of Midbrain Dopamine Neurons.
Granholm, A-C, Reyland, M., Albeck, D., Sanders, L., Gerhardt GA, Hoernig, G.,
Shen, L., Westphal, H., and Hoffer, B. J.
Neurosci. 20(9):3182-3190, 2000.
- In vivo microdialysis studies of age-related alterations in potassium-evoked
overflow of dopamine in the dorsal striatum of Fischer 344 rats.
Stanford, J.A., Giardina, K., and
Gerhardt
GA. Int. J.
Develop. Neurosci. (18)4-5:411-416, 2000.
- Multiple single-unit recordings in the
striatum of freely moving animals: Effects of apomorphine and d-amphetamine in
normal and unilateral 6-hydroxydopamine-lesioned rats.
Kish,
L.J., Palmer, M.R. and Gerhardt GA. Brain Res. 833:58-70,
1999.
-
Differences in the pharmacological properties
of dopamine release between the substantia nigra and striatum: an in vivo
electrochemical study.
Hoffman, A.F. and Gerhardt GA. JPET, 289:455-463, 1999.
-
Age-related reductions in [3H] 35,428 binding to the dopamine transporter
in nigrostriatal and mesolimbic brain regions of the Fischer 344 rat.
Hebert,
M.A., Larson, G.A., Zahniser, N.R., and
Gerhardt
GA. JPET,
288:1334-1339, 1999.
- Voltage-dependency of the dopamine transporter in the rat substantia nigra.
Hoffman, A.F., Zahniser, N.R., Lupica, C.R., and
Gerhardt
GA.
Neurosci. Lett., 260:105-108, 1999.
- In vivo dopamine clearance rate in rat striatum: regulation by extracellular
dopamine concentration and dopamine transporter inhibitors. Zahniser, N.R., Larson, G.A., and
Gerhardt
GA.JPET,
289:266-277, 1999.
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GDNF improves dopamine function in the substantia nigra but not the putamen of
unilateral MPTP-lesioned Rhesus monkeys. Gerhardt GA, Cass, W.A., Huettl, P., Brock, S., Zhang, Z., and Gash, D.M. Brain Res., 817:163-171, 1999.
-
Methodology for coupling local application of dopamine and other
chemicals with rapid in vivo electrochemical recordings in freely moving
rats.
Gerhardt GA, Ksir, C., Pivik, C., Dickinson, S.D., Sabeti, J., and Zahniser,
N.R. J. Neurosci. Meth., 87:67-76, 1999.
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Microdialysis studies of basal levels and
stimulus-evoked overflow of dopamine and metabolites in the striatum of young
and aged Fischer 344 rats.
Gerhardt GA and Maloney, R.E. Brain Res., 816:68-77, 1999.
- Age-related changes in the capacity, rate and
modulation of dopamine uptake within the striatum and nucleus accumbens of
Fischer 344 rats: An in vivo electrochemical study.
Hebert,
M.A. and Gerhardt GA. JPET, 288:879-887, 1999.
-
Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter
function but no changes in dopamine release in dorsal striatum.
Dickinson, S.D., Sabeti, J., Larson, G.A., Giardina, K., Rubinstein, M.,
Kelly, M.A., Grandy, D.K., Low, M.J., Gerhardt GA, and Zahniser, N.R.
J.
Neurochem., 72:148-156, 1998.
- Dopamine transporter activity in the substantia nigra and striatum assessed by
high-speed chronoamperometric recordings in brain slices.
Hoffman, A.F., Lupica, C.R., and
Gerhardt
GA. J. Pharmacol. Exp.
Therapeut., 287:487-496, 1998.
- In vivo electrochemical studies of dopamine clearance in subregions of rat
nucleus accumbens: differential properties of the core and shell. David,
D., Zahniser, N.R., Hoffer, B.J., and
Gerhardt
GA. Exp.
Neurol., 153:277-286, 1998.
- Age-related decline in striatal dopamine release and motoric function in brown
Norway/Fischer 344 hybrid rats. Yurek,
D.M., Hipkens, S.B., Gash, D.M., and
Gerhardt
GA. Brain Res., 791:246-256, 1998.
- Locomotor activity in D2 dopamine receptor-deficient mice is determined
by gene dosage, genetic background and developmental adaptations.
Kelly,
M.A., Rubinstein, M., Lessov, C.N., Burkhart-Kasch, S., Zhang, G., Saez, C.,
Bunzow, J.R., Fang, Y., Gerhardt GA, Phillips, T.J., Grandy, D.K., and Low,
M.J. J.
Neurosci., 18:3470-3479, 1998.
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Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts
to the 6-OHDA-lesioned striatum and improve behavioral recoveryGranholm, A.-Ch., Henry, S., Hebert, M., Eken, S., Gerhardt G, and van Horne,
C. . Cell
Transplant., 7:197-212, 1998.
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In vivo electrochemical studies of dopamine
clearance in the rat substantia nigra: effects of locally applied uptake
inhibitors and unilateral 6-OHDA lesions.
Hoffman, A.F. and Gerhardt GA. J. Neurochem., 70:179-189, 1998.
-
In vivo electrochemical measurements of serotonin clearance in rat striatum:
effects of neonatal 6-hydroxydopamine-induced serotonin hyperinnervation and
serotonin uptake inhibitors. Luthman, J., Friedemann, M.N., Hoffer, B.J., and
Gerhardt
GA. J. Neural Tran., 104:379-397, 1997.
- Effects of ethanol on striatal dopamine overflow and clearance: An in vivo
electrochemical study.
Wang,
Y., Palmer, M.R., Cline, E.J., and
Gerhardt
GA.
Alcohol, 14:593-601, 1997.
-
Glial cell line-derived neurotrophic factor
improves survival of ventral mesencephalic grafts to the 6-OHDA lesioned
striatum. Granholm, A.-Ch., Mott, J.L., Eken, S., van Horne, C., Bowenkamp, K., Hoffer,
B., Henry, S., and Gerhardt GA.. Exp. Brain Res., 116:29-38, 1997.
- Behavioral and neurochemical effects of intranigral
GDNF administration on aged Fischer 344 rats. Hebert,
M.A. and Gerhardt GA. J. Pharmacol. Exp. Therapeut.,
282:760-768, 1997.
- Caloric
restriction enhances evoked DA overflow in striatum and nucleus accumbens of
aged Fischer 344 rats.
Diao,
L.H., Bickford, P.C., Stevens, J.O., Cline, E.J., and Gerhardt GA. Brain Res., 763:276-280, 1997.
- The effects of local application of ethanol in the n.
accumbens on dopamine overflow and clearance.
Samson,
H.H., Hodge, C.W., Erickson, H.L., Niehus, J.S., Gerhardt GA, Kalivas, P.W.,
and Floyd, E.A. Alcohol, 14:485-492, 1997.
-
In
vivo microdialysis studies of somatodendritic dopamine release in the rat
substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.
Hoffman, A.F., van Horne, C.G., Eken, S., Hoffer, B.J. and Gerhardt G. Exp.
Neurology, 147:130-141, 1997.
- Functional effects of GDNF in normal rat striatum: Presynaptic studies using
in vivo electrochemistry and microdialysis. Hebert,
M.A., van Horne, C.G., Hoffer, B.J., and
Gerhardt
GA. J. Pharmacol. Exp. Therapeut.,
279:1181-1190, 1996.
- Functional recovery
in parkinsonian monkeys treated with GDNF. Gash,
D.M., Zhiming, Z., Ovadia, A., Cass, W., Yi, A., Simmerman, L., Russell, D.,
Lapchak, P., Collins, F., Hoffer, B.J., and Gerhardt GA.. Nature, 380:252-255, 1996.
-
In vivo electrochemical studies of the
dynamic effects of locally applied excitatory amino acids in the striatum of
the anesthetized rat. Friedemann, M.N. and Gerhardt GA.. Exp. Neurol., 138:53-63, 1996.
-
In vivo electrochemical studies of
dopamine overflow and clearance in the striatum of normal and MPTP-treated
rhesus monkeys.
Gerhardt GA, Cass, W.A., Hudson, J., Henson, M., Zhang, Z., Ovadia, A.,
Ketonen, E., Hoffer, B.J., and Gash, D.M. J. Neurochem., 66:579-588, 1996.
- Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys.Gash,
D.M., Zhang, Z., Cass, W.A., Ovadia, A., Martin, D., Russell, D., Collins, F.,
Hoffer, B.J., and Gerhardt G. J. Comp. Neurol.,
363:345-358, 1995.
-
Age-related changes in potassium-evoked overflow of dopamine in
the striatum of the rhesus monkey.
Gerhardt GA, Cass, W.A., Henson, M., Zhang, Z., Ovadia, A., Hoffer, B.J., and
Gash, D.M. Neurobiology of Aging, 16(6):939-946,
1995.
- Medial dorsal
striatum is more sensitive than lateral dorsal striatum to cocaine inhibition
of exogenous dopamine clearance: Relation to striosome/matrix and [3H]
mazindol binding.Cline,
E.J., Adams, C.E., Larson, G.A., Gerhardt GA, and Zahniser, N.R. Exp. Neurology, 134:135-149, 1995.
- In vivo assessment of dopamine uptake in rat medial
prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens.
Cass,
W.A. and Gerhardt GA.. J.
Neurochem., 65:201-207, 1995.
- Glial cell
line-derived neurotrophic factor supports survival of injured midbrain
dopaminergic neurons. Bowenkamp, K.E., Hoffman, A.F.,
Gerhardt
GA,
Henry, M.A., Biddle, P.T., Hoffer, B.J., and Granholm, A-C.E. J. Comparative Neurology, 355:479-489, 1995.
- Glial cell
line-derived neurotrophic factor augments midbrain dopaminergic circuits in
vivoHudson,
J., Granholm, A-C., Gerhardt GA, Henry, M.A., Hoffman, A., Biddle, P., Leela,
N.S., Mackerlova, L., Lile, J.D., Collins, F., and Hoffer, B.J. . Brain Res. Bull., 36:425-432, 1995.
- Increased dopamine
clearance in the non-lesioned striatum of Rhesus monkeys with unilateral MPTP
striatal lesionsCass,
W.A., Gerhardt GA, Zhang, Z., Ovadia, A. and Gash, D.M. . Neurosci. Letters 185:52-55, 1995.
- Glial cell line-derived neurotrophic factor reverses
toxin-induced injury to midbrain dopaminergic neurons in vivo. Hoffer,
B.J., Hoffman, A., Bowenkamp, K., Huettl, P., Hudson, J., Martin, D., Line,
L-F. and Gerhardt GA.. Neurosci.
Lett. 182:107-111, 1994.
- Direct in vivo evidence that D2 dopamine receptors can
modulate dopamine uptake.
Cass,
W.A. and Gerhardt GA.. Neurosci. Lett., 176:259-263, 1994.
- Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens:
Role of metabolism and effects of locally applied uptake inhibitors.
Cass,
W.A., Zahniser, N.R., Flach, K.A. and
Gerhardt
GA..
J.
Neurochem., 61:2269-2278, 1993.
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Correlation of
apomorphine- and amphetamine-induced turning with nigrostriatal dopamine
content in unilateral 6-hydroxydopamine lesioned rats. Hudson,
J.L., van Horne, C.G., Strömberg,
I., Brock, S., Clayton, J., Masserano, J., Hoffer, B.J. and
Gerhardt GA.. Brain Res.
626:167-174, 1993.
- In vivo electrochemical measurements of exogenous dopamine clearance in normal
and neonatal 6-hydroxydopamine-treated rat striatum.
Luthman, J., Friedemann, M.N., Hoffer, B.J. and
Gerhardt
GA.. Exp. Neurol.,
122:273-282, 1993.
- Reduced clearance of exogenous dopamine in rat nucleus accumbens, but
not in dorsal striatum, following cocaine challenge in rats withdrawn from
repeated cocaine administration.Cass,
W.A., Gerhardt GA, Gillespie, K., Curella, P., Mayfield, R.D. and Zahniser,
N.R. J. Neurochem., 61:273-283, 1993.
-
In vivo electrochemical measurements and electrophysiological
studies of rat striatum following neonatal 6-hydroxydopamine treatment.
Luthman, J., Friedemann, M., Bickford, P., Olson, L., Hoffer, B.J. and
Gerhardt GA.. Neuroscience 52:677-687, 1993.
- Clearance and diffusion of locally applied dopamine in normal and
6-hydroxydopamine-lesioned rat striatum. J. Pharmacol.van
Horne, C., Hoffer, B.J., Strömberg,
I. and
Gerhardt
GA. Exp. Ther.
263:1285-1292, 1992.
- Eighteen-month course of two patients with grafts
of fetal dopamine neurons for severe Parkinson's disease. Hoffer,
B.J., Leenders, K.L., Young, D., Gerhardt G, Zerbe, G.O., Bygdeman, M., Seiger,
Å., Olson, L., Strömberg,
I. and Freedman, R. Exp. Neurol.,
118:243-252, 1992.
- Direct in vitro electrochemical measurement of dopamine overflow in
intermediate pituitary: characterization and pharmacology.
Williams, P.J., Dunwiddie, T.V. and
Gerhardt
GA..J. Pharm. Exp. Ther.
261:403-411, 1992.
-
Differences
in dopamine clearance and diffusion in rat striatum and nucleus accumbens
following systemic cocaine administration.
Cass,
W.A., Gerhardt GA, Mayfield, R.D., Curella, P. and Zahniser, N.R. J. Neurochem. 59:259-266, 1992.
-
Regional effects of aging on dopaminergic
function in the Fischer 344 rat.
Friedemann, M.N. and Gerhardt GA.. Neurobiology of Aging 13:325-332, 1992.
- Effects of dopamine
receptor agonists and antagonists on catecholamine release in bovine chromaffin cells.Huettl,
P., Gerhardt GA, Browning, M.D. and Masserano, J.M. J. Pharmacol. Exp. Ther. 257(2): 567-574, 1991.
- Dopamine D2 receptor agonists inhibit the calcium-evoked release of endogenous
dopamine from striatal synaptosomes.Masserano, J.M., Bowyer, J.F. and
Gerhardt
GA.. Annals of the New York Academy of
Sciences, 604:629-631, 1990.
-
The effects of cholecystokinin (CCK-8) on dopamine containing nerve terminals in the
caudate nucleus and nucleus accumbens of the anesthetized rat: An in vivo
‑electrochemical study.
Gerhardt GA, Friedemann, M., Brodie, M.S., Vickroy, T.W., Gratton, A.P.,
Hoffer, B.J. and Rose, G.M.
Brain Res., 499: 157-163, 1989.
-
In vivo electrochemical studies of the
effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the
neostriatum of the anesthetized rat.Friedemann, M. and Gerhardt GA.. Proc. West Pharmacol. Soc. 32: 143-147,
1989.
-
Human fetal mesencephalic tissue grafted to dopamine-denervated striatum of athymic rats:
Light- and electron-microscopical histochemistry and in vivo
chronoamperometric studies.
Strömberg, I., Almqvist, P., Bygdeman, M., Finger, T., Gerhardt G, Granholm,
A.-Ch., Mahalik, T., Seiger, A., Hoffer, B. and Olson, L. J. Neurosci., 9: 614-624, 1989.
-
Outflow and overflow of picogram levels of endogenous dopamine and DOPAC from rat striatal slices:
Improved methodology for studies of stimulus-evoked release and metabolism.
Gerhardt GA, Dwoskin, L.P. and Zahniser, N.R. J.
Neurosci. Meth., 26: 217-227, 1989.
- Effects of electrical stimulation of brain
reward sites on release of dopamine in rat: An in vivo electrochemical study.
Gratton,
A., Hoffer, B.J. and Gerhardt GA.Brain Res. Bull., 21: 319-324, 1988.
-
Potentiation of
morphine-elicited circling by dopaminergic uptake blockade.
Gratton, A., Hoffer, B.J., Gerhardt GA and Wise, R.A.Pharmacol. Biochem. Behav., 30: 1077-1079, 1988.
-
In vivo electrochemical studies of
the effects of cocaine on dopamine nerve terminals in the rat neostriatum.
Gerhardt GA, Gratton, A. and Rose, G.M. Physiologia Bohemoslovaca, 37: 249-257, 1988.
- The effects of delta-9-tetrahydrocannabinol
on potassium-evoked release of dopamine in rat caudate nucleus: An in vivo
electrochemical and in vivo microdialysis study.
Ng
Cheong Ton, J.M., Gerhardt GA, Friedemann, M., Etgen, A.M., Rose, G.M.,
Sharpless, N.S. and Gardner, E.L. Brain Res., 451: 59-68,
1988.
- Modulation of the gating of auditory
evoked potentials by norepinephrine and dopamine: Pharmacological evidence
obtained using a selective neurotoxin.
Adler,
L.E., Pang, K., Gerhardt G and Rose, G. Biological Psychiatry, 24: 179-190,
1988.
- Reproducibility of the
measurement of plasma noradrenergic and dopaminergic metabolites in normal
subjects. Baker,
N.J., Adler, L.E., Waldo, M., Gerhardt G, Drebing, C., Cox, B., Berry, S.,
Macdonald, M., Phillips, W. and Freedman, R. Psychiatry Res. 23:119-130, 1988.
-
Release of monoamines from striatum
of rat and mouse evoked by local application of potassium: Evaluation of a new
in vivo electrochemical technique.
Gerhardt GA, Rose, G.M. and Hoffer, B.J. J. Neurochem., 46: 842-850, 1986.
- Age-related alterations in
monoamine release from rat striatum: An in vivo electrochemical study.
Rose,
G.M., Gerhardt GA, Conboy, G.L. and Hoffer, B.J. Neurobiol. of Aging, 7: 77-82, 1986.
- Dopaminergic
neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the
mouse: An in vivo electrochemical study.
Gerhardt G, Rose, G., Strömberg,
I., Conboy, G., Olson, L., Jonsson, G. and Hoffer, B. J. Pharmacol. Exp. Ther., 235:
259-265, 1985.
- Monoamine release
from dopamine-depleted rat caudate nucleus reinnervated by substantia nigra
transplants: An in vivo electrochemical study. Rose,
G., Gerhardt G, Strömberg, I., Olson, L. and Hoffer, B. Brain Res., 341: 92-100,
1985.
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