Susanne Marksbery Arnold, M.D.
Associate Professor
Rose Carol Shumate Professorship in Cancer Research
Susanne M. Arnold, M.D.
Associate Professor of Medicine
Clinical Interests: Lung Cancer, Head and Neck Cancers
I. Office Address
Markey Cancer Center, cc445
800 Rose Street
Lexington, KY 40536
e-mail: smarno0@uky.edu
Phone:(859)323-8043
Fax: (859)257-7715
II. Certifications and Licensures:
1995-2015: American Board of Internal Medicine
1998-2018: ABIM Subspecialty: Medical Oncology
1995 - present: Kentucky License: 31171
III. Education:
1981-1985: Brown University
Bachelor of Arts, Educational Philosophy
1988-1992: University of Kentucky College of Medicine
Doctor of Medicine (with high distinction)
June 1996: American Association for Cancer Research
Molecular Biology in Clinical Oncology Workshop
September 2003: Hope Foundation/OrthoBiotech Young Investigators Workshop
Southwest Oncology Group
IV. Professional Experience and Academic Appointments:
1992-1995: University of Virginia Health Sciences Center
Internship and Residency, Internal Medicine
1995-1998: University of Kentucky Chandler Medical Center
Fellowship, Medical Oncology and Hematology
July 2005-Present: Associate Professor of Medicine (Primary Appointment)and Radiation Medicine (Joint Appointment)
Chandler Medical Center, University of Kentucky
May 1999-June 2005: Assistant Professor of Medicine (Primary Appointment)
Division of Hematology and Oncology
Chandler Medical Center, University of Kentucky
April 2003-June 2005: Assistant Professor of Radiation Medicine (Joint Appointment)
Department of Radiation Medicine
Chandler Medical Center, University of Kentucky
1998-1999: Clinical Instructor
Division of Hematology and Oncology
Chandler Medical Center, University of Kentucky
V. Hospital Appointments:
1998-present: A.B. Chandler Medical Center, University of Kentucky
1998-present: Veterans Administration, Lexington, KY
2004-2011: Rockcastle County Hospital, Mt. Vernon, KY
VI. Consulting Activities:
National:
September 2000-present: Writer/Consultant for American Board of Internal Medicine, Medical Oncology Subspecialty Board Exams
March 2005- present: Consultant for the University of Kentucky Colleges of Pharmacy and Medicine Office of Continuing Education: Content reviewer for oncology presentations throughout the United States
May 2006-present: Reviewer, Head and Neck
Local/Regional:
June 2006: Reviewer, Center for the Advancement of Women grant applications; American Cancer Society Institutional Grants
2010: Reviewer, Kentucky Lung Cancer Research Grants
VII. Administrative Activities and University Service:
Sept 2003-2007: Member, Southwest Oncology Group’s Head and Neck Disease Site Committee
Dec 2003-present: Member, UK Healthcare Advisory Board
March 2004-Oct 2004: Member, Neoplasm & Hematology Strategic Planning Workgroup
May 2004-present: Program Leader in Lung Cancer, 5th District Proposal
May 2004-Sept 2004: Member, Kentucky Lung Cancer Research Governance Board
June, 2004-present: Member, Markey Cancer Center Scientific Council
Oct 2004: Member, Task Force on Women’s Issues, Department of Medicine
November 2004- present: Medical Director, Cancer Services, Rockcastle Hospital and Respiratory Care Center
November 2004-May 2005: Medicine Resident Interviewer
March 2005-present: Institutional Principal Investigator, Southwest Oncology Group
April 2005-November 2005: Co-Chair, Radiation Chair Search Committee
September 2005-present: UK HealthCare Facility Planning & Development, Design Development Team, Inpatient Room User Group
July 2006-2007: Member, Outreach Task Force, Clinical Trials Support Unit Development Team
August 2007-present: Member, University of Kentucky Senate (3-year term)
August 2009-present: Member, Early Therapeutics Steering Committee
February 2010-present: Leader, Lung Cancer Research Initiatives, Markey Cancer Center
March, 2010-present: Leader, Experimental Therapeutics CCART, Markey Cancer Center
August 2010-Sept 2010: Member, Dean’s 6-year Review Committee for Department of Surgery
August 2010-present: Member, Markey Clinical and Research Leaders Committee
VIII. Teaching Activities:
Lectures:
1998: Problem Based Learning
1999: Non-small Cell Lung Cancer I&II, Head and Neck Cancer, Cancer of Unknown Primary, Chemoprevention, Chemotherapy and Clinical Trials in Head and Neck Cancer, Neutropenic Fever, Board Review, Oncology
2000: Internal Medicine Grand Rounds, Superior Sulcus Tumors, Cancer of Unknown Primary Site
2001: Desmoid Tumors, Head and Neck Cancer, Chemoprevention, Chemotherapy and Clinical trials in Head and Neck Cancer
2002: Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Low Dose Radiation in Head and Neck Cancer
2003: Small Cell Lung Cancer, Unknown Primary Cancer, Lung Cancer, Head and Neck Cancer
2004: Unknown Primary Cancer, Medical Oncology Emergencies (2)
2005: Head and Neck Cancer, Medical Oncology Emergencies, Non-small Cell Lung Cancer, Early Stage Non-small Cell Lung Cancer, Late Stage Non-small Cell Lung Cancer, Medical Oncology Emergencies, Small Cell Lung Cancer, Radiation and Chemotherapy Interactions (BIO 740)
2006: Unknown Primary Cancer, Lung Cancer, Medical Oncology Emergencies, Board Review--Sarcoma, Board Review—Pharmacology, Head and Neck Cancer
2007: Non-small Cell Lung Cancer I & II, Head and Neck Cancer, Medical Oncology Emergencies, Radiation and Chemotherapy Interactions (BIO 740), Unknown Primary Cancer, Lung Cancer, Medical Oncology Emergencies
2008: Small Cell Lung Cancer, Head and Neck Cancer, Radiation and Chemotherapy Interactions (BIO 740), Unknown Primary Cancer, Lung Cancer, Medical Oncology Emergencies
2009: Medical Oncology Emergencies, Radiation and Chemotherapy Interactions (BIO 740), Non-small Cell Lung Cancer, Chemotherapy Mechanism of Action
2010: Medical Oncology Emergencies, Radiation and Chemotherapy Interactions (BIO 740), Chemotherapy Mechanism of Action,
2011: How I Treat Lung Cancer, Cancer therapy-experimental (MI-616)
Attending Duties:
• Attending, Medical Oncology Consult and Inpatient Services approximately 3-4 months per year.
• Supervisory clinic attending for fellows and residents two full-day clinics per week.
• Medical Director of Hematology and Oncology services for Rockcastle Hospital and Respiratory Care Center from 11/14/04 to present, with 1-2 full-day clinics per month at Rockcastle Hospital.
IX. Advising Activities:
1999-2002: Advisor, Internal Medicine Housestaff (Brian Kee)
2000-2002: Advisor, Internal Medicine Housestaff (Ewa Bak)
2001-2003: Advisor, Internal Medicine Housestaff (Kelly Tritt)
2003-2005: Advisor, Internal Medicine Housestaff (Christopher John Stark)
2005-2007: Advisor, Internal Medicine Housestaff (Val Macrinici)
2005-2007: Advisor, Internal Medicine Housestaff (Brooke Phillips)
2009-present: Graduate Student Advisory Committee for Post-doctoral student, Eleftheria Tsakalozou, College of Pharmacy
2010-present: Collaborator on Nanotechnology Training Grant, PI, Brad Anderson, PhD and Mark Evers, MD, PhD
X. Special Assignments:
Arnold, SM. An Analysis of Non-Small Cell Lung Cancer Statistics from the University of Kentucky Cancer Registry, 1994-1998. Annual University of Kentucky Cancer Registry Review, October 20, 1999.
Developed the Kentucky Lung Cancer Research Program’s Clinical Trials Network Review and Prioritization Process as a member of the Clinical Trials Network Oversight Committee, Subcommittee of the Kentucky Lung Cancer Research Board.
XI. Honors and Awards:
1985: Member, Educational Policy Committee, Brown University
1990: Outstanding Student for Excellence in Physical Diagnosis
1991: Academic Excellence Scholarship
1991: Alpha Omega Alpha, Vice President
1992: Senior Class President
1992: Louise Perkins McHenry Cup in Obstetrics and Gynecology
1992: Carey Cup in Emergency Medicine
1992: Outstanding Fourth Year Student for Scholarship and Humanism in Internal Medicine
1992: D. Kay Clawson Award for Scholarship and Leadership
1994: Resident Teaching Award, University of Virginia
1995: W. Leroy Dunn Award for Leadership in Residency
2002: Kentucky Lung Cancer Research Fund, Research Fellowship
2003: Kentucky Lung Cancer Research Fund, Research Fellowship
2003: Hope Foundation/OrthoBiotech Young Investigators Workshop for Southwest Oncology Group
2007: Rose Carol Shumate Professorship in Cancer Research
XII. Professional Affiliations and Public Service:
1991: Alpha Omega Alpha
1996: American Association for Cancer Research (#13881)
1996: American Society of Clinical Oncology (#29247)
1998: Southwest Oncology Group Member (#24255)
1998: National Cancer Institute Investigator (#27639)
1998: Radiation Therapy Oncology Group (institution # 0526)
1998: National Surgical Adjuvant Breast and Bowel Project (institution # 182)
2000: American College of Surgeons Oncology Group
2002: American Society for Therapeutic Radiology and Oncology (#35155967)
2002: Women Against Lung Cancer
2008: CTEP Investigator
XIII. Research and Scholarship:
Am J Hospice and Pall Med, 2008 25(1): 39-44.
Shareef MM, Brown B, Shajahan S, Sathishkumar S, Arnold SM, Mohiuddin M, Ahmed MM, Spring PM. Lack of P-glycoprotein expression by low-dose fractionated radiation results from loss of nuclear factor-kappaB and NF-Y activation in oral carcinoma cells. Mol Cancer Res. 2008 Jan 6(1):89-98.
Jacobs-Lawson, J. M., Schumacher, M., Hughes, T., & Arnold, S. The relationship between lung cancer patients' education level and evaluation of their treatment information needs. J Cancer Ed, 2009 24, 346-350.
Stults DM, Killen MW, Williamson EP, Hourigan JS, Vargas HD, Arnold SM, Moscow JA and Pierce AJ. Human Ribosomal RNA Gene Clusters are Recombinational Hotspots in Cancer. Cancer Res. 2009 Dec 1;69(23):9096-104.
Arnold SM, Rinehart JJ, Tsakalozou E, Eckardt JJ, Fields SZ, Shelton BJ, DeSimone PA, Kee BK, Moscow JA, Leggas M. A Phase 1 Study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin (AR-67) in Adult Patients with Refractory or Metastatic Solid Malignancies. Clin Cancer Res. 2010 Jan 15;16(2):673-80.
Wang-Gillam A, Arnold SM, Bukowski RM, Rothenberg ML, Cooper W, Wang KK, Gauthier E, Lockhart AC. A phase I dose escalation study of TTI-237 in patients with advanced malignant solid tumors. Invest New Drugs. 2010 Aug 10.
Jacobs-Lawson JM, Schumacher MM, Hughes T, Arnold SM. Gender differences in psychosocial responses to lung cancer. Gend Med 2010 Apr;7(2):137-48.
Gupta S, Koru-Sengul T, Arnold SM, Devi G, Mohiuddin M, Ahmed M. Low-dose fractionated radiation potentiate the effects of Cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. Accepted, Mol Cancer Therapeutics, 10/10.
Warren GW, Arnold SM, Valentino J, Gal TJ, Hyland A, Cummings KM, Marshall J, Kudrimoti M. The Accuracy of Self-Reported Tobacco Assessment at Baseline and During Cancer Treatment in Head and Neck Cancer Patients. Submitted, J Clinicl Oncol, 12/10.
Horn J, Milewska M, Arnold, SM, Leggas, M. Metabolic pathways of the camptothecin analogue AR-67 Drug Metab Dispos. 2010 Dec 28 (epub).
Davis B, Arnold SM. Nut Midline Carcinomas: A Lethal and Under-Recognized Entity. Accepted Archives of Pathology & Laboratory Medicine, 2011.
Arnold SM, Moon, JM, Williamson SK, Atkins JN, Ou SI, LeBlanc M, Urba SG. Phase II Evaluation of Eribulin mesylate (E7389, NSC 707389) in Patients with Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck: Southwest Oncology Group Trial S0618. Invest New Drugs. 2011 29(2): 352-359.
Extramural Funding, Other:
1. Rose Carol Shumate Professorship in Cancer Research, awarded July, 31, 2007.
2. Research Fellowship, Kentucky Lung Cancer Research Project, $20,000, September 1, 2003-September 1, 2004.
3. Research Fellowship, Kentucky Lung Cancer Research Project, $20,000, September 1, 2002-September 1, 2003.
* For a complete list of current and past funding, advisory board positions, and publications, please e-mail Meredith Boarman at mtboar2@uky.edu.
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