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Barnstable Brown Obesity and Diabetes Research Day






Peter Reaven, M.D.
"Diabetes and Vascular Disease: New Research and Clinical Complications"

Peter Reaven, M.D. Peter Reaven Is a Research Professor at the Biodesign Institute at Arizona State University. He is also a Professor of Clinical Medicine at the University of Arizona. He is the Director of the Diabetes Program Veterans Affairs Health Care System. His research interests include the study of the mechanisms and treatment of diabetes and the scope of his research includes large, prospective, multicenter randomized clinical trials as well as basic research into the signaling process involved with vascular inflammation and dysfunction. His group has led the investigation into the role of saturated fatty acids in inducing monocyte and vascular inflammation in diabetes, described the role of adipose inflammation in atherosclerosis as well as effects of older and novel anti-diabetes medications on vascular complications in diabetes. His group, therefore, has extensive expertise in identifying inflammatory signaling pathways leading to vascular dysfunction in the setting of metabolic stress.

Jean Schaffer, M.D.
"Unexpected Regulators of Metabolic Stress”

Jean Schaffer is the Virginia Minnich Distinguished Professor of Medicine and Director of the Diabetic Cardiovascular Disease Center and Diabetes Research Center at Washington University School of Medicine. Her research lab is focused on characterizing the fundamental cellular mechanisms of metabolic stress and characterizing how this process contributes to the pathogenesis of metabolic diseases. Work in her lab involves genetic screens in cultured cells to identify molecular mechanisms, study of genetically modified mouse models to characterize the contributions of these mechanisms to pathophysiology, and extension of their findings to biomarker and intervention studies in human subjects. Given the high prevalence of metabolic disease and the significant morbidity and mortality which cardiovascular complications entail, they are motivated to translate their findings to human subjects. Ongoing work in the Schaffer laboratory is focusing on development of integrated measures of systemic lipid metabolism and identification of biomarkers for diabetic complications related to lipotoxicity. Jean Schaffer, M.D.

Randy Seeley, Ph.D.
"Bariatric Surgery: It’s not what you think it is. Molecular targets for the effects of surgery on obesity and diabetes

Randy Seeley, Ph.D. Randy Seeley is Professor of Medicine and holds the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine. In 2009, Dr. Seeley was appointed as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the actions of various peripheral hormones in the CNS that serve to regulate food intake, body weight and the levels of circulating fuels. In particular, he has focused upon the numerous hypothalamic and G.I. peptides and their associated receptors that influence both energy intake as well as peripheral metabolic processes with a focus on developing new treatment strategies for both obesity and diabetes.

Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before locating to the University of Cincinnati in 1997. He has published over 225 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Cell Metabolism, The Journal of Clincial Investigation and the New England Journal of Medicine. Collectively, this work has been cited more than 20,000 times. He is the recipient of the 2003 Lilly Scientific Achievement Award from the North American Association for the Study of Obesity (now named The Obesity Society) given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree. He is also the co-recipient of the 2008 Ernst Oppenheimer award from the Endocrine Society. This Award is the premier award to an investigator under the age of 45 in recognition of meritorious accomplishment in the field of basic or clinical endocrinology. He also received the 2009 Outstanding Scientific Achievement Award (sometimes referred to as the “Lilly Award”) from the American Diabetes Association. This award is presented to an individual medical researcher under age 45 who has made an outstanding contribution to diabetes research that demonstrates both originality and independence of thought.

Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He currently serves on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science.

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