Shuxia Wang, M.D., Ph.D.
Chair of Graduate Center for Nutritional Sciences
Graduate Center for Nutritional Sciences
Room 583, Wethington Building
900 S. Limestone
University of Kentucky
Lexington, KY 40536-0200
Tel: (859)-323-4933 ext 81367
Listings on PubMed
• Graduate Center for Nutritional Sciences
• M.D., Shanxi Medical University, China
• Ph.D., Peking Union Medical College & CAMS, China
• Postdoctoral Fellow, Department of Vascular Biology, Jerome Holland Lab in American Red Cross, MD, USA
• Postdoctoral Fellow, Department of Pathology, University of Alabama at Birmingham, AL, USA
• Juvenile Diabetes Research Foundation, Postdoctoral fellowship
• University of Alabama at Birmingham, Career Development Award
• American Heart Association, Scientist Development Award
Specific Interest in Nutrition:
Mechanisms of diabetic, renal and vascular complications.
Diabetic renal and vascular complications are the major causes of morbidity and mortality in diabetic patients. Identification of the cellular and molecular mechanisms that trigger the development of these complications is important for development of therapeutic interventions. Research in Dr. Wang’s lab has demonstrated that glucose-mediated upregulation of thrombospondin1 (TSP1) expression and TSP1-dependent TGF-β activation occurs through down-modulation of Nitric Oxide (NO)/cGMP/cGMP–Dependent protein kinase (PKG) signaling pathway. Current research projects in her lab are to determine the molecular mechanisms by which glucose and PKG regulate TSP1 expression, contributing to the activation of latent TGF-β in diabetic renal and vascular complications. These studies will provide novel therapeutic approaches to attenuate the development of diabetic complications.