Lisa R. Tannock, M.D.
Associate Professor of Medicine and Chief
Division of Endocrinology and Molecular Medicine
Room 567, Wethington Building
Graduate Center for Nutritional Sciences
900 S. Limestone
University of Kentucky
Lexington, KY 40536-0200
For Appointments (859) 323-2232
Tel: (859)-323-4933 ext 81415
Fax: (859)-257-3646
e-mail: Lisa.Tannock@uky.edu
Academic Appointments:
• Graduate Center for Nutritional Sciences
• Division of Endocrinology and Molecular Medicine
• Department of Internal Medicine
Education:
• M.D., University of Toronto
• Residency, Internal Medicine, University of Toronto
• Postdoctoral Fellow, Metabolism, Endocrinology and Nutrition, University of Washington
Awards:
• Samuel Castrilli Award, University of Toronto
• Murray Muirhead Award, University of Toronto
• American Federation of Medical Research, University of Washington
• Aventis Scholar, American Federation for Medical Research Western Section
• Aventis Scholar, American Federation for Medical Research Western Section
• Juvenile Diabetes Foundation International Postdoctoral Fellow
• American Diabetes Association Junior Faculty Award
• University of Kentucky Physician Scientist Award
Specific Interest in Nutrition:
Role of proteoglycans in complications of diabetes and obesity.
Research:
Proteoglycans have been shown to play a critical role in the initiation of atherosclerosis due to their ability to bind atherogenic lipoproteins leading to retention in the artery wall, as outlined in the “response to retention hypothesis”. Research in Dr. Tannock's laboratory aims to identify the role of proteoglycans in the pathogenesis of complications of diabetes and obesity, including atherosclerosis and nephropathy. Current studies are using angiotensin II to regulate vascular proteoglycans in animal models of diabetes, obesity, and atherosclerosis. Related studies are examining the interaction between inflammatory mediators/ markers and vascular proteoglycans. A major focus of the lab is to identify the underlying mechanisms that regulate proteoglycan synthesis and subsequently influence proteoglycan-lipoprotein interactions. Results from these studies will advance our understanding of the mechanisms of atherosclerosis, and may identify novel therapeutic targets to decrease lipoprotein retention as a strategy to prevent complications of diabetes and obesity.
Representative Publications:
1. Tannock LR , Little PJ, Wight TN, Chait A: Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced LDL binding. J Lipid Res 43:149-157, 2002.
2. Tannock LR , Olin KL, Wight TN, Chait A: Triglyceride-rich lipoproteins from subjects with type 2 diabetes do not demonstrate increased binding to biglycan, a vascular proteoglycan. J Clin Endo Metab 87:35-40, 2002.
3. Little PJ, Tannock LR, Olin KL, Chait A, Wight TN: Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor beta-1 exhibit increased binding to low density lipoproteins. Arterioscler Thromb Vasc Biol 22:55-60, 2002.
4. Herbst KL, Tannock LR, Deeb SS, Purnell JQ, Brunzell JD, Chait A: Köbberling Type of Familial Partial Lipodystrophy: An Underrecognized Syndrome. Diabetes Care 26:1819-1824, 2003.
5. Meyers CD, Tannock LR, Wight TN, Chait A: Statin exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. J Lipid Res 44:2152-2160, 2003
6. Tannock LR , Chait A: Lipoprotein-matrix Interactions in macrovascular disease in diabetes. Invited Review, Frontiers in Bioscience 9:1728-1742, 2004.
7. Tannock LR , Little PJ, Tsoi C, Barrett PHR, Wight TN, Chait A: Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans. Diabetologia 47:837-843, 2004.
8. Renard CB, Kramer F, Johansson F, Lamharzi N, Tannock LR, von Herrath MG, Chait A, Bornfeldt KE. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest 114(5):659-668, 2004.
9. Chait A, Lewis K, Tannock L, O’Brien K, Retzlaff B, Kahn S, Knopp R, Wight T. Nutrition and inflammation: role of dietary cholesterol. Atherosclerosis XIII. Proceedings of the 13 th International Atherosclerosis Symposium, International Congress Series. 1262:313-316, 2004.
10. Tannock LR , O’Brien KD, Knopp RH, Retzlaff B, Fish B, Wener MH, Kahn SE, Chait A: Cholesterol feeding increases CRP and SAA levels in lean, insulin sensitive subjects. Circulation 111:3058-3062, 2005.
|
