James C. Matthews, Ph.D.
Associate Professor of Animal Sciences
Department of Animal and Food Sciences

808 W.P. Garrigus Bldg.
Lexington, KY 40546-0215
Tel: (859)-257-7513
Fax: (859)-257-3412
e-mail: jcmatthew@uky.edu

Education:

• Ph.D. in Animal Science, Virginia Tech, 1995.

Special Interest in Nutrition:

Nutrition and Chronic Diseases (aging) and Animal Nutrition (nutritional physiology).

Research:

Regulation of expression and function of amino acie and nucleoside transporters and metabolizing enzymes throughout the mammalian life cycle.

Publications:

Recent Refereed Articles (of 23)

1. Novak, D., F. Quiggle, and J. C. Matthews. 2004. Androgen Secretion by Rcho-1 Cells is Independent of Extracellular Glutamate Concentration. Placenta 25:548-552.

2. Fan, M. Z., J. C. Matthews, N. M. P. Etienne, D. G. Burrin, and B. Stoll. 2004. Expression of Apical Membrane L-glutamate Transporters in Neonatal Porcine Epithelial Cells Along the Small Intestinal Crypt-villus Axis. American Journal of Physiology- Gastrointestinal and Liver Physiology 287:G385-G398.

3. Swanson, K. C., J. A. Benson, J. C. Matthews, and D. L. Harmon. 2004. Influence of Starch Hydrolysate and/or Casein on Pancreatic Exocrine Secretion and Plasma Hormone Concentrations in Beef Steers. Journal of Animal Science 82:1781-1787.

4. Rodriguez, S. M., K. C. Guimaraes, J. C. Matthews, K. R. McLeod, R. L. Baldwin, VI and D. L. Harmon. 2004. Influence of Abomasal Carbohydrates on Small Intestinal Sodium-dependent Glucose Cotransporter Activity and Abundance in Steers. Journal of Animal Science 82:3015-3023.

5. Swanson, K. C., J. C. Matthews, C. A. Woods, and D. L. Harmon. 2003. Influence of Substrate and/or Neurohormonal Mimic on In Vitro Pancreatic Enzyme Release from Calves Postruminally Infused with Partially Hydrolyzed Starch and/or Casein. Journal of Animal Science 81:1323-1331.

6. Novak, D. A. and J. C. Matthews. 2003. Glutamate transport by Rcho-1 cells derived from rat placenta. Pediatric Research 53(5):1-5.

7. Howell, J. A., A. D. Matthews, T. C. Welbourne, and J. C. Matthews. 2003. Content of Ileal EAAC1 and Hepatic GLT-1 High-Affinity Glutamate Transporters is Increased in Growing Versus Non-Growing Lambs, Paralleling Increased Tissue Concentrations of D- and L-Glutamate and Plasma Glutamine and Alanine. Journal of Animal Science 81:1030-1039.

8. Swanson, K. C., J. C. Matthews, C. A. Woods, and D. L. Harmon. 2002. Post-Ruminal Administration of Partially Hydrolyzed Starch and Casein Influences Pancreatic a-Amylase Expression in Calves. Journal of Nutrition 132:376-381.

9. Matthews, J. C. and K. J. Anderson. 2002. Recent Advances in Amino Acid Transporters and Excitatory Amino Acid Receptors. Current Opinion in Clinical Nutrition and Metabolic Care 5:77-84.

10. Howell, J. A., A. D. Matthews, K. C. Swanson, D. L. Harmon, and J. C. Matthews. 2001. Molecular Identification of High-Affinity Glutamate Transporters in Sheep and Cattle Forestomach, Intestine, Liver, Kidney, and Pancreas. Journal of Animal Science 79:1329-1336.

11. Swanson, K. C., J. C. Matthews, A. D. Wilson, J. A. Howell, C. J. Richards, and D. L. Harmon. 2000. Influence of Dietary Carbohydrate Source and Energy Intake on Pancreatic a-Amylase Expression in Lambs. Journal of Nutrition 130:2157-2165.

12. Welbourne, T., and J. C. Matthews. 1999. Glutamate Transport and Renal Function. American Journal of Physiology 277(Renal Physiol. 46):F501-F505.

13. Matthews, J. C., M. J. Beveridge, E. Dialynas, A. Bartke, M. S. Kilberg, and D. A. Novak. 1999. Placental Cationic and Anionic Amino Acid Transporter Expression in Growth Hormone Overexpressing, Null IGF-II or Null IGF-1 Receptor Mice. Placenta 20:639-650.

14. Matthews, J. C., M. J. Beveridge, M. S. Malandro, J. D. Rothstein, M. Campbell-Thompson, J. E. Verlander, M. S. Kilberg, and D. A. Novak. 1998. Activity and Protein Localization of Multiple Glutamate Transporters in Gestation Day 14 Versus Day 20 Rat Placenta. American Journal of Physiology 274 (Cell Physiol. 43):C603-614.

Recent Invited Book Chapters (of 10):

1. Zanghi, B. M., and J. C. Matthews. 2005. Physiological Importance and Mechanisms of Protein Hydrolysate Absorption. In: V. Pasulouppi (Ed.) Protein Hydrolysates in Nutrition and Biotechnology. Chapter V, pp. 1-43. Kluwar Academic Publishers, Amersterdam. Accepted.

2. Matthews, J. C., and G. L. Sipe. 2005. Regulation of High-Affinity Glutamate Transporter Expression in Developing Ruminants. Invited Main Paper on Nutritional Regulation of Gene Expression. Proceedings of the Xth International Symposium on Ruminant Physiology, Copenhagen, Denmark. In press.

3. Matthews, J. C.. Expression and Function of Non-Organelle Glutamate Transporters To Support Peripheral Tissue Function. 2005. In: S. Gill and O. Pulido (Eds.) Glutamate Receptors in Peripheral Tissues: Excitatory Transmission Outside the CNS. Chapter 3, pp. 47-75. Kluwer Academc/Plenum Press, New York.

4. Krehbeil, C. R., and J. C. Matthews. Absorption of Amino Acids and Peptides. 2003. In: J. P. F. D’Mello (Ed.) Amino Acids in Animal Nutrition, 2nd edition. Chapter 3, 41-70. CAB International, Wallingford.

5. Matthews, J. C.. 2000. Mechanisms of Peptide and Amino Acid Transport. In: J. P. F. D’Mello (Ed.) Farm Animal Metabolism and Nutrition: Critical Reviews. Chapter 1, 3-23. CAB International, Wallingford.

Recent Invited Seminars (of 12):

1. Patterns and Putative Regulatory Pathways of High-Affinity Glutamate Transporter Expression by Ruminants. January 15, April 2005. Virginia Tech Department of Dairy Science Seminar, Blacksburg, VA.

2. Nutritional Regulation of Gene Expression: Regulation of High-Affinity Glutamate Transporter Expression in Developing Ruminants. August 30 to September 4, 2004. Invited Main Paper for Nutrient Regulation of Gene Expression, Xth International Symposium on Ruminant Physiology, Copenhagen, Denmark.

3. Coordinated Expression of Proteins that Transport and Metabolize Glutamate to Support Altered Gut and Peripheral Tissue Function: A work in progress. April 27, 2004. Virginia Tech Nutrition Seminar, Blacksburg, VA.

4. Altered Expression of High-Affinity Glutamate Transporters to Support Changing Gut and Peripheral Tissue Metabolism of Developing Ruminants. February 17, 2004. Texas A&M Faculty of Nutrition Seminar, College Station, TX.

Patent :

Compositions and Methods for Increasing Amino Acid Absorption in Mammals (U.S. Patent number 6803186). G. M. Davenport (The IAMS Company) and J. C. Matthews (PI; University of Kentucky). Awarded October 12, 2004.

Recent Abstracts (of 35):

1. Sipe, G. L., B. M. Zanghi, G. Wu, J. A. Boling, and J. C. Matthews. 2005. Blood Chemical and Plasma Amino Acid Profiles of Old Versus Mature Young Beef Cows. Accepted by Journal of Animal Science 83 (suppl. 1): abstract no. 10163).

2. Zanghi, B. M., N. M. P. Etienne, A.D. Matthews, E. D. Miles, G. M. Davenport, and J. C. Matthews. 2005. Cloning and In Vitro Characterization of Dog PepT1 and Development of a Polarized Cell Model to Study PepT1 Trafficking and Regulation. In press, Journal of Animal Science 83 (suppl. 1): abstract no. 9930.

3. Zanghi, B. M., G. L. Sipe, G. M. Davenport, and J. C. Matthews. 2005. Feeding of Chicken or Soy Protein-Based Diet Differentially Affects In Vivo PepT1 Uptake Capacity in Dogs. In press, Journal of Animal Science 82 (suppl. 1): abstract no. ).

4. Miles, E. D., J. A. Boling, and J. C. Matthews. 2005. Specific Glutamate and Nucleoside Transport Activities of Madin-Darby Bovine Kideny (MDBK) Cells Are Inhibited by the Ergopeptide Bromocryptine. In press, Journal of Animal Science 83 (suppl. 1): abstract no. 10032).

5. Kitts, S. E., J. C. Matthews, G. L. Sipes, T. S. Rumsey, T. H. Elasser, R. L. Baldwin, and K. R. McLeod. 2004. Effects of Chlortetracycline (CTC) and Steroidal Implant on Growth and Plasma Growth Hormone (GH) and Thyroid-Stimulating Hormone (TSH) After Challenge with Thyroid-Releasing Hormone (TRH) and GH-Releasing Hormone (GHR) on Finishing Beef Steers. Journal of Animal Science 82 (suppl. 1):41.

6. Sipe, G. L., S. E. Kitts, K. R. McLeod, and J. C. Matthews. 2004. Chlortetracycline, but not Synovex-S, Differentially Affects Tissue Expression of High-Affinity Glutamate Transporters in Fattening Steers. Journal of Animal Science 82 (suppl. 1):42.

7. Zanghi, B. M., G. L. Sipe, G. M. Davenport, and J. C. Matthews. 2004. Evaluation of Glycylsarcosine and Cefadroxil as Substrates for Non-invasive Determination of Canine Small Intestine PepT1 Capacity and Demonstration That Maximal Cefadroxil Absorption Occurs When Consumed 4 h After Meal Ingestion. Journal of Animal Science 82 (suppl. 1): 245.

8. Gissendanner, S. J., N. M. P. Etienne, and J. C. Matthews. 2003. Differential Expression of EAAC1 and GLT-1 Glutamate Transporters by Bovine Epithelial Tissues is not Altered by Physiological Development. FASEB Journal 17(5):A305.

9. Gissendanner, S. J., N. M. P. Etienne, K. R. McLeod, and J. C. Matthews. 2003. The Pattern of EAAC1 and GLT-1 Glutamate Transporter Expression by Skeletal Muscle and Adipose Tissues of Fattening Cattle Differs from that of Glutamine Synthetase. FASEB Journal 17(5):A738.