Charles D. Smith, M.D.

UK Department of Anatomy and Neurobiology

Jointly Appointed Faculty

Charles D. Smith, M.D.
Tulane Medical School (1979), Professor of Neurology

Research Interests: Neuroimaging and Dementia

My main research interest is application of neuroimaging methods to aging and to neurodegenerative disease. I am also interested in motor function, particularly in aging and Parkinson’s disease.

Representative Publications

Smith C.D., D.A. Snowdon, and W.R. Markesbery W.R. Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings. Journal of Neuroimaging, 10:13-16, 2000.

Smith C.D., D.A. Snowdon, H. Wang, and W.R. Markesbery. White matter volumes and periventricular white matter hyperintensities in aging and dementia. Neurology, 54:838-842, 2000.

Snowdon, D.A., C.L. Tully, C.D. Smith, K.P. Riley, and W.R. Markesbery. Serum folate and the severity of atrophy of the neocortex in Alzheimer's disease: Findings from the Nun study. Journal of Clinical Nutrition, 71:993-998, 2000.

Zhang Z., A. Andersen, C.D. Smith, R. Grondin, G. Gerhardt, and D.M. Gash. Motor slowing and parkinsonian signs in aging Rhesus monkeys mirror human aging. Journal of Gerontology: Biological Sciences, 55A: B473-B480, 2000.

Schmitt F.A., D.G. Davis, D.R. Wekstein, C.D. Smith, J.W. Ashford, and W.R. Markesbery. “Preclinical" AD revisited: neuropathology of cognitively normal older adults. Neurology, 55:370-376, 2000.

Kessler-West, M.L., A.H. Andersen, C.D. Smith, M.J. Avison, C.E. Davis, R.J. Kryscio, and L.X. Blonder. Neural Substrates of Facial Emotion Processing Using fMRI. Cognitive Brain Research, 11: 213-226, 2001.

Smith C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison. Differences in Functional MRI Activation by Category in a Visual Confrontation Naming Task. Journal of Neuroimaging, 11: 165-170, 2001

Wackerbarth S.B., M.S. Johnson, W.R. Markesbery, and C.D. Smith. Urban-Rural Differences in a Memory Disorders Clinical Population. Journal of the American Geriatric Society, IN PRESS, 2001.

Smith C.D. A hypothalamic stroke producing recurrent hemi-hyperhidrosis. Neurology, 56: 1394-1396, 2001.

Goshe, KM, JA Mortimer, CD Smith, WR Markesberry, and DA Snowden. An automated technique for measuring hippocampal volumes from MR studies. AJNR 22: 1686-1689, 2001.

Smith, CD. Serial MRI findings in a case of primary lateral sclerosis. Neurology 57: 647-49, 2002.

Smith, CD, AH Andersen, RJ Kryscio, FA Schmitt, MS Kindy, LX Blonder, and MJ Avison. Women at high risk for Alzheimer's disease show increased parietal activation in a letter fluency task. Neurology 58: 1197-1202, 2002.

Robertson, WC and Smith, CD. Sydenham's chorea in the age MRI: A case report and review of the literature. Pediatric Neurology 27: 65-7, 2002.

Gosche, KM, JA Mortimer, CD Smith, WR Markesberry, DA Snowden. Hippocampal volume as an index of ALzheimer neuropathology: findings from the nun study. Neurology 58: 1476-82, 2002.

Baker, RS, A Andersen, R Morecraft, CD Smith. Brain activation patterns during blinking: a functional MRI study of benign essential blepharospasm. Journal of Neurophthalmology in press.

Gaugler, JE, SA Wackerbarth, M Mendiondo, FA Schmitt and CD Smith. Characteristics of dementia caregiving onset. American Journal of Alzheimer's disease in press.

E-mail: csmith@mri.uky.edu
Phone: (859)323-1113