Ph.D., The Ohio State University (2001)
Postdoctoral Training, Princeton University
Assistant Professor of Anatomy and Neurobiology, Molecular & Cellular Biochemistry
LUKE H. BRADLEY, Ph.D.
Ph.D., The Ohio State University (2001)
Postdoctoral Training, Princeton University
Assistant Professor of Anatomy and Neurobiology,
Molecular & Cellular Biochemistry
Research Interests:
Alternate peptide and protein scaffolds for biotherapeutic discovery and
development
The Bradley
laboratory utilizes protein engineering and synthetic biology
approaches, at the interface of chemistry and biochemistry, to discover
and develop peptide and protein-based molecules as platforms for
various biotechnical, neurobiological, and biotherapeutic applications.
The long-term goal of the laboratory is to translate this research
towards the treatment of neurodegenerative disorders, including
Parkinson's disease.
Recent Publications
Bradley LH, Bricken ML, Randle C. (2011) “Expression, Purification, and Characterization of Proteins from High-Quality Combinatorial Libraries of the Mammalian Calmodulin Central Linker.” Protein Expression & Purification 75(2):186-192.
Fisher MA, McKinley KL, Bradley LH, Viola SR, Hecht MH. (2011) “De novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth.” PLoS ONE 6(1): e15364.
Bradley LH, Fuqua J, Richardson A, Turchan-Cholewo J, Ai Y, Kelps KA, Glass J, He X, Zhang Z, Grondin R, Littrell OM, Gash DM, Gerhardt GA. (2010) “Dopamine Neuron Stimulating Actions of a GDNF Propeptide.” PLoS ONE 5(3): e9752.
Patel SC, Bradley LH, Jinadasa SP, Hecht MH. (2009) “Cofactor Binding and Enzymatic Activity in an Unevolved Superfamily of De Novo Designed 4-Helix Bundle Proteins.” Protein Science 18:1388-1400.
Bradley LH, Thumfort PP, Hecht MH. (2006) "De Novo Proteins from Binary Patterned Combinatorial Libraries." Methods Molecular Biology 340: 53-69.
Bradley LH, Kleiner RE, Wang AF, Hecht MH, Wood DW. (2005) “An Intein-Based Genetic Selection Enables Construction of a High-Quality Library of Binary Patterned De Novo Protein Sequences.” Protein Engineering, Design & Selection 18: 201-207.
Contact Info
Interested undergraduates should contact Dr. Bradley regarding research opportunities for the Spring 2011 semester.
Office: MN222
Medical Education Building
Email: lhbradley@uky.edu
Phone: (859) 323-1826
Fax: (859) 323-5946
Website: Bradley
Laboratory (external link)
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