LUKE H. BRADLEY, Ph.D.LUKE H. BRADLEY, Ph.D.

UK Department of Anatomy and Neurobiology

Faculty Research

LUKE H. BRADLEY, Ph.D.
Ph.D., The Ohio State University (2001)
Postdoctoral Training, Princeton University
Assistant Professor of Anatomy and Neurobiology, Molecular & Cellular Biochemistry

Research Interests: Central nervous system protein recognition, specificity, and design

Research in the Bradley laboratory utilizes approaches at the interface of chemistry, biochemistry, and molecular biology to advance our understanding of protein structure and function in the central nervous system. We are using protein design, molecular screening and evolution techniques to develop molecules with specific biological activities. Detailed biochemical and biophysical characterization of these molecules will contribute towards understanding the basis of the native protein’s function. In addition, these molecules will serve as translational platforms for the development of various medical, biotechnical, and therapeutic applications.

Recent Publications

Patel SC, Bradley LH, Jinadasa SP, Hecht MH. (2009) “Cofactor Binding and Enzymatic Activity in an Unevolved Superfamily of De Novo Designed 4-Helix Bundle Proteins.” Protein Science, 18:1388-1400.

Bradley LH, Thumfort PP, Hecht MH. (2006) "De Novo Proteins from Binary Patterned Combinatorial Libraries." in Methods in Molecular Biology, vol.340 : Protein Design: Methods and Applications (Guerois R. & Lopez de la Paz M., Eds.) Humana Press, Towota, NJ, 340: 53-69.

Bradley LH, Kleiner RE, Wang AF, Hecht MH, Wood DW. (2005) “An Intein-Based Genetic Selection Enables Construction of a High-Quality Library of Binary Patterned De Novo Protein Sequences.” Protein Engineering, Design & Selection 18: 201-207.

Office: MN222 Medical Education Building
Email: lhbradley@uky.edu
Phone: (859) 323-1826
Fax: (859) 323-5946