People > Gerald Supinski, MD
Gerald Supinski, MD
Dr. Supinski is a Professor of Medicine, Associate Chair of the Department of Medicine for Research and a member of the Division of Pulmonary and Critical Care Medicine. Dr. Supinskiís research focuses on two topics: respiratory failure in critically ill patients and multiorgan system failure in sepsis. Dr. Supinski has been continuously funded by the NIH for over 20 years and has been the recipient of 8 RO1 awards during this time. He has also received grant support from the American Heart Association, the VA research program, the American Thoracic Society and was a recipient of a Trudeau Scholar Award by the American Thoracic Society. Dr. Supinski has published over 100 pier reviewed articles, 7 book chapters and 140 presentations at national meetings. Dr. Supinski was head of the Pulmonary/Critical Care Pulmonary/Critical Care fellowship training program at Case Western Reserve University for over 10 years before coming to the University of Kentucky and has directly supervised the research training programs of 12 pulmonary fellows. Physicians previously mentored by Dr. Supinski include 3 faculty members at prominent US medical schools (Case Western Reserve University, University of Kentucky, Yale) and professors in Japan and Israel. Dr. Supinski has served as a Member of the NIH Skeletal Muscle and Exercise Biology Study section. He is also currently a member of the national Research Advocacy Committee of the American Thoracic Society.
My laboratory focuses on two areas of research: (a) respiratory muscle dysfunction in critically ill patients, and (b) the mechanisms of organ failure and death from sepsis. Both topics are related to critical care medicine. The goal of our study of respiratory muscle dysfunction is to discover new treatments designed to improve weaning patients from mechanical ventilation, thereby reducing patient morbidity. The goal of our study of sepsis is to discover new treatments to prevent multiorgan failure, the leading cause of death in intensive care units in the United States. We use animal models of disease to establish disease mechanisms and to trial new therapies and we also study human patients in the ICU to allow us to translate basic science discoveries into clinical therapies. Our laboratory uses a mixture of techniques to accomplish these objectives, including proteomic assessments, physiological assessment of organ and cell function, biochemical assessment of enzyme pathways, cell culturing techniques, fluorescent microscopy, molecular techniques to alter gene expression, assessment of organ function in critically ill patients (muscle cardiac, vascular, lung), and muscle biopsy techniques in patients.
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