Center for Muscle Biology

PGY 630 Advanced Skeletal Muscle Physiology

Overview - Schedule - Course Announcement - Course-related files

Overview

PGY 630 Advanced Skeletal Muscle Physiology is a graduate level class designed primarily for PhD students who are working in the general area of striated muscle biology. The 2009 class is being run jointly by Drs. Karyn Esser and Kenneth Campbell.

2009 Schedule

Chapter numbers refer to "The Physiology of Excitable Cells" by David Aidley (4th Edition).

Course Announcement

This is a 2 credit class that will go into advanced and fundamental concepts about the structure and function of adult skeletal muscle. It will be a 2 hour classroom meeting with 1 hour independent study per week. The specific date, time and location of the weekly meeting is to be determined.

Grading: 2 papers (90% of the grade) will be required from each student. Each paper will be approximately 2500 words in length and will present a detailed review of a structural and/or functional aspect of skeletal muscle. Ten percent (10%) of the grade will come from class participation.

Textbook: For the first 50% of the class we will be using The Physiology of Excitable Cells, 4th Edition by Aidley. This book can be ordered (new or used) through Amazon or other online bookstores. Each student will need their own copy of the book. Dr. Esser and Campbell will select primary research papers for the rest of the class.

Topics will include:

• Nerve-muscle interactions: structure and properties of the neuromuscular junction
• Excitation contraction coupling: DHPR, ryanodine receptor, SERCA
• Muscle mechanics: force-velocity; length tension relationships, cross-bridge cycle
• Muscle structure: myofilaments, sarcoplamic reticulum, mitochondria, nuclear domains
• Critical analysis of experimental techniques as they apply to each topic

Please email Karyn ( karyn.esser@uky.edu ) or Ken ( k.s.campbell@uky.edu ) if you have questions.

The course is listed as PGY630 under Esser.

Course related files

• Discussion questions (01/20/2009) - Word file, opens in new window
• Discussion questions (02/03/2009) - Word file, opens in new window
• Discussion questions (02/10/2009) - Word file, opens in new window
• Discussion questions (02/17/2009) - Word file, opens in new window

• Reading for February 10 (Contractile machinery, Campbell)
  • Huxley, A.F. (1957) (Access from UK campus only)
  • Huxley, A.F. & Simmons, R.M. (1971) (Access from UK campus only)
  Reading for February 17 (Contractile machinery, Campbell)
  • Ford, L.E., Huxley, H.E. and Simmons, R.M. (1977)