CHARLES SMITH, M.D.
Dr. Smith is a professor in the Department of Neurology at the University of Kentucky College of Medicine. He is the director of the Alzheimer's Disease Research Center (ADRC) Memory Disorders Clinic at the University of Kentucky Sanders-Brown Center on Aging .He is also the director of the  Magnetic Resonance Imaging and Spectroscopy center at University of Kentucky. He received his medical degree in 1979 at Tulane University in New Orleans, and completed his neurology residency at Dartmouth in 1984. Dr. Smith is currently funded for studies of Cognitive Reseach as a Protective Factor for Dementing Diseases (Kleberg Foundation) and Detection of Presymptomatic Alzheimer's Disease utilizing fMRI (National Institute of Nerology Disorders and Stroke).

University of Kentucky
Albert B. Chandler Medical Center
Department. of Neurology
L454 Kentucky Clinic
800 Rose St.
Lexington, KY 40536-0084
Phone: (859) 323-1113
E-mail: csmith@mri.uky.edu

RECENT PUBLICATIONS (in chronological order)

Zhang Z, Andersen A, Smith CD, Grondin R, Gerhardt G, Gash DM. Motor slowing and Parkinsonian signs in aging Rhesus monkeys mirror human aging.  J Gerontol Biol Sci 2000; 55A: B473-B480.

Smith CD, Snowdon DA, Wang H, Markesbery WR. White matter volumes and periventricular white matter hyperintensities in aging and dementia.  Neurology 2000; 54:838-842.

Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR. Serum folate and the severity of atrophy of the neocortex in Alzheimer's disease: Findings from the Nun study.  J Clin Nutrition 2000; 71:993-998.

Schmitt FA, Davis DG, Wekstein DR , Smith CD, Ashford JW, Markesbery WR. “Preclinical" AD revisited: neuropathology of cognitively normal older adults.  Neurology 2000; 55:370-376.

Kessler-West ML, Andersen AH, Smith CD, Avison MJ, Davis CE, Kryscio RJ, Blonder LX. Neural Substrates of Facial Emotion Processing Using fMRI.  Cog Brain Research 2001; 11: 213-226.

Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Differences in Functional MRI Activation by Category in a Visual Confrontation Naming Task.  J Neuroimaging 2001; 11: 165-170.

Wackerbarth SB, Johnson MMS, Markesbery WR, Smith CD. Urban-Rural Differences in a Memory Disorders Clinical Population.  J. Amer. Geriatr Soc 2001; 49:647-650.

Smith CD. A hypothalamic stroke producing recurrent hemi-hyperhidrosis.  Neurology 2001; 56: 1394-1396.

Gosche KM, Mortimer JA, Smith C.D, Markesbery WR, Snowdon DA. An automated technique for measuring hippocampal volumes from MR studies.  AJNR 2001; 22:1686-1689.

Smith CD. Serial MRI Findings in a Case of Primary Lateral Sclerosis.  Neurology 2002; 57:647-649.

Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Women At High Risk For Alzheimer's Disease Show Increased Parietal Activation in a Letter Fluency Task.  Neurology 2002; 58:1197-1202.

Robertson WC, Smith C.D. Sydenham’s chorea in the age of MRI: a case report and review of the literature.  Pediatr Neurol 2002; 27:65-67.

Gosche KM, Mortimer JA, Smith CD, Markesbery WR, Snowdon DA. Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun study.  Neurology 2002; 58: 1476-1482.

Baker RS, Andersen A, Morecraft R, Smith CD. A Functional Magnetic Resonance  Imaging Study in Patients with Benign Essential Blepharospasm. J Neuro-ophthalmol 2003; 23: 11-15.

Gaugler JE, Wackerbarth,SA, Mendiondo M, Schmitt FA, Smith CD. Characteristics of dementia caregiving onset.  Am J Alzheimer's Disease 2003; 18: 97-104. 

Gaugler JE, Mendiondo M, Smith CD, Schmitt FA.  Secondary dementia caregiving and its consequences.  Am J Alzheimer's Disease 2003; 18: 300-308.

Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio R, Wekstein D, Smith CD, Markesbery WR, Mattson MP. Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and
vaccine development. Neuromolecular Med 2003;3:29-39.

 
Blonder LX, Smith CD, Davis CE, Kessler-West ML, Garrity, TF, Avison MJ, Andersen AH. Regional brain response to faces of dogs and humans. Cogn Brain Res 2004; 20:384-394.

Gaugler JE, Anderson KA, Leach, CR, Smith, CD, Schmitt, FA., Mendiondo, M. The emotional ramifications of unmet need in dementia caregiving. American Journal of Alzheimer’s Disease 2004; 19:369-379.

Smith CD, Walton A, Loveland AD, Umberger GH, Kryscio RJ, Gash DM. Memories that last in old age: motor skill learning and memory preservation. Neurobiol Aging. 2005;26:883-890. 

Riel-Romero RMS, Smith CD, Pettigrew AL. Megalencephalic Leukoencephalopathy With Subcortical Cysts in Two Siblings owing to two Novel Mutations: Case reports and Review of the Literature".  J Child Neurol 2005;20:230-234.

Riel-Romero RMS, Baumann RJ, Smith CD. An unusual complication of treatment for acute lymphoblastic leukemia. J Neuro-oncology 2005; 73:269-272.

Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Research on Parkinson disease. J Neurosurg. 2005;102:401(Commentary).

Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J Neurosurg. 2005;102:216-22.

Smith CD, Kryscio RJ, Schmitt FA, Lovell MA,  Blonder LX, Rayens RA, Andersen, AH. Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease. J Neuroimaging 2005; 15:271-277.

Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. The neuropathologic substrate of mild cognitive impairment. Arch Neurol 2005; 63:38-46.

Smith CD, Wekstein DR, Markesbery WR, Frye CA. 3[alpha],5[alpha]-THP: A Potential Plasma Neurosteroid Biomarker in Alzheimer's Disease and Perhaps Non-Alzheimer's Dementia. Psychopharmacology (Special Issue on Neurosteroids). 2005; 18:1-5.

Chebrolu H, Slevin JT, Gash DM, Gerhardt GA , Young B, Given CA, Smith CD. MRI Volumetric and Intensity Analysis of the Cerebellum in Parkinson's Disease Patients Infused with Glial-Derived Neurotrophic Factor (GDNF). Exper Neurol 2006; 198:450-6.

Espinosa PS, Kryscio RJ, Mendiondo MS, Schmitt FA, Wekstein DR, Markesbery WR, Smith CD. Alzheimer’s disease and head circumference. Journal of Alzheimer's Disease 2006; 9:77-80.

Espinosa PS, Berger JR, Smith CD. Homonymous hemianopsia complicating treatment of postoperative epistaxis. Neurology 2006; 67:1305.

Forman M, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu P-H, Watts GD, Markesbery WR, Smith CD, Kimonis VE. Novel ubiquitin neuropathology in frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol 2006; 65:571-581

Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. Age and gender effects on human brain anatomy: a voxel based morphometric study in healthy elderly. Neurobiol Aging 2006 (Epub 2006; In Press)

Gold BT, Balota DA, Jones SJ, Powell DK, Smith CD, Andersen AH. Dissociation of automatic and strategic lexical-semantics: fMRI evidence for differing roles of multiple frontotemporal regions. J Neurosci 2006; 26:6523-6532.

Espinosa PS, Smith CD, Berger JR. Alien Hand Syndrome and Hemispatial Neglect. Neurology 2006; 67:E21.

Slevin JT, Gerhardt GA, Smith CD, Gash DM, Young AB. Reply: GDNF poses troubling questions for doctors, drug maker (Commentary). Ann Neurol 2006; 59:989-90.

Slevin, JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young BA.  Unilateral intraputaminal glial cell line–derived neurotrophic factor in patients with Parkinson disease: response to one year each of treatment and withdrawal. J Neurosurg 2007;106:1-7.

Mehta SG,Watts CDJ, Adamson J, Hutton M, G. Umberger G, Xiong S, Ramdeen S, Lovell M, Kimonis VE, Smith CD. APOE is a Potential Modifier Gene in an Autosomal Dominant Form of Frontotemporal Dementia (IBMPFD). Genet Med 2007; 9:9-13.

Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, SmithCD, Taylor JP, Kretzschmar KZ, Kimonis VE, Forman F. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 2007; 66:152-57.

Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR. Brain Structural Alterations Before Mild Cognitive Impairment. Neurology 2007; 68:1268-1273.

Kimonis VE, Mehta SG, Fulchiero EC, Thomasova D, Pasquali M, Boycott K, Neilan EG, Kartashov A, Forman MS, A. Brownell KW, Tucker S, Kimonis K, Mumm S, Whyte M, Smith CD, Watts GDJ. Clinical and molecular studies in nine families with familial myopathy, Paget disease of bone and frontotemporal dementia. Am J Med Genet 2007 (In Press).