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Anders Anders Ph.D.

Anders Andersen, Ph.D.
Research Associate Professor of Anatomy and Neurobiology
Purdue University, 1983
Room 37 Davis Mills (0098)
Phone: (859) 323-1108
E-mail: anders@mri.uky.edu

I hold a Ph.D. in Electrical Engineering in the area of signal and image processing and have nearly thirty years of post-graduate experience working in this field.  I joined the Magnetic Resonance Imaging and Spectroscopy Center (MRISC) when the facility opened in the Fall of 1991.  In addition to pursuing my own research interests, I collaborate with a large number of both new and established investigators across a range of academic departments on projects where I contribute to data analyses across many imaging modalities.

Research Interest:  Functional Neuro Imaging

My research focuses on issues in biomedical signal and image processing, particularly in the context of magnetic resonance imaging of brain function based on the endogenous blood oxygenation level dependent (BOLD) contrast mechanism.  Maps of the spatial distribution of brain activation are computed from functional MRI data acquired during sensori-motor or cognitive tasks in humans, as well as from studies involving pharmacological stimulation of the dopaminergic nigrostriatal neural circuitry in non-human primates.  My interest in imaging includes all aspects of the overall process from mathematical modeling of the interaction of the mode of interrogation with tissue matter, data pre-processing, formulation of the inverse problem, image reconstruction, as well as image post-processing and detectability issues.


SELECTED PEER-REVIEWED  PUBLICATIONS

Liu, Y., W. Rayens, A. Andersen, and C. Smith, "Partial least squares discrimination with heterogeneous covariant structures," Journal of Chemometrics (to appear).

Gold, B.T., D.K. Powell, A.H. Andersen, and C.D. Smith, "Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease," NeuroImage, October 2010, 52(4):1487-1494.

Smith, C.D., H. Chebrolu, A.H. Andersen, D.A. Powell, M.A. Lovell, S. Xiong, and B.T. Gold, "White matter diffusion alterations in normal women at risk of Alzheimer's disease," Neurobiology of Aging, July 2010, 31(7):1122-1131.

Gold, B.T., A.H. Andersen, G.A. Jicha, and C.D. Smith, "The neural correlates of word recognition performance in aging:  Evidence that aging influences strategic but not automatic components," Cerebral Cortex, November 2009, 19(11):2671-2691.

Hardy, P.A., and A.H. Andersen, "Calculating T2 images from a phased array receiver," Magnetic Resonance in Medicine, April 2009, 61(4):962-969.

Rayens, W., Y. Liu, A. Andersen, and C. Smith. "Using OrPLS to identify asymptotic women at risk for Alzheimer's disease," Journal of Chemometrics, September 2008, 22:522-527.

Luan, L., F. Ding, Y. Ai, A.H. Andersen, P.A. Hardy, E. Forman, G.A. Gerhardt, D.M. Gash, R. Grondin, and Z. Zhang, "Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys," Cell Transplant, 2008, 17(4):417-425.

Cass, W.A., R. Grondin, A.H. Andersen, Z. Zhang, P.A. Hardy, L.K. Hussey-Andersen, W.S. Rayens, G.A. Gerhardt, and D.M. Gash, “Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys,” Neurobiology of Aging, Feb. 2007, 28(2):258-271.   

de Leeuw, R., C.E. Davis, R. Albuquerque, C.R. Carlson, and A.H. Andersen, "Brain activation during stimulation of the trigeminal nerve with noxious heat," Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, December 2006, 102(6):750-757.

Zhang, Z., A.H. Andersen, Y. Ai, A. Loveland, P.A. Hardy, G.A. Gerhardt, and D.M. Gash, “Assessing Nigrostriatal Dysfunctions by Pharmacological MRI in Parkinsonian Rhesus Macaques,” NeuroImage, Oct. 2006, 33(2):636-643.
   

Joseph, J.E., D.K. Powell, A.H. Andersen, R.S. Bhatt, M.K. Dunlap, S.T. Foldes, E. Foreman, P.A. Hardy, N.A. Steinmetz, and Z. Zhang, “Novelty detection in alert, behaviorally naïve rhesus monkeys using functional magnetic resonance imaging,” Journal of Neuroscience Methods, Oct. 2006, 157(1):10-24.
   

Rayens, W.S., and A.H. Andersen, “Multivariate analysis of fMRI data by oriented partial least squares (OrPLS),” Magnetic Resonance Imaging, Sept. 2006, 24(7):953-958.

Albuquerque
, R.J.C., R. de Leeuw, C.R. Carlson, J.P. Okeson, C. Miller, and A.H. Andersen, “Cerebral activation during thermal stimulation of burning mouth disorder patients:  An fMRI study,” Pain, June 2006, 122(3):223-234.   

Gold, B.T., D.A. Balota, S.J. Jones, D.K. Powell, C.D. Smith, and A.H. Andersen, “
Dissociation of automatic and strategic lexical-semantics: fMRI evidence for differing roles of mid-IT and multiple frontal regions,” J. Neuroscience, June 2006, 26(24):6523-6532.   

de Leeuw, R., R.J. Albuquerque, A.H. Andersen, and C.R. Carlson, “Influence of estrogen on brain activation during stimulation with painful heat,” Journal of Oral and Maxillofacial Surgery, Feb. 2006, 64(2):158-166.
   

Smith, C.D., G.A. Umberger, R.J. Kryscio, F.A. Schmitt, M.A. Lovell, L.X. Blonder, W.S. Rayens, and A.H. Andersen, “Longitudinal functional alterations in asymptomatic women at risk for Alzheimer’s disease.” J. Neuroimaging, July 2005, 15(3): 271-277.
 

Hardy, P.A., D.M. Gash, R. Yokel, A.H. Andersen, Y. Ai, and Z Zhang, “Correlation of R2 with total iron concentration in the brains of rhesus monkeys,” J. Magn. Reson. Imaging, February 2005, 21(2): 118-127.

Blonder, L.X., M.L. Kesler/West, C.D. Smith, C.E. Davis, M.J. Avison, and A.H. Andersen, “Regional brain responses to faces of animals vs people,” Cognitive Brain Research, August 2004, 20(3): 384-394.
 

Andersen, A.H
., and W.S. Rayens, “Structure-seeking multilinear methods for the analysis of fMRI data,” NeuroImage, June 2004, 22: 728-739.   

Rayens, W.S., and A.H. Andersen, “Partial least squares as a target-directed structure-seeking technique,” Chemometrics and Intelligent Laboratory Systems, 2004, 71: 121-127.
   

Rayens, W.S., and A.H. Andersen, “Oriented partial least squares,” Invited.  Rivista di Statistica Applicata - Italian Journal of Applied Statistics, July 2003, 15(3): 367-388.  

Baker, R.S., A.H. Andersen, R.J. Morecraft, and C.D. Smith, “Brain activation patterns during blinking:  A functional MRI study of benign essential blepharospasm,” J. Neuro-Ophthalmology, 2003,
23: 11 -15.   

Andersen, A.H
., Z. Zhang, M.J. Avison, and D.M. Gash, “Automated segmentation of multispectral brain MR images,” J. Neuroscience Methods, 2002, 122: 13-23.

Grondin, R., Z. Zhang, A. Yi, W.A. Cass, N. Maswood, A.H. Andersen, D.D. Elsberry, M.C. Klein, G.A. Gerhardt, and D.M. Gash, “Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced Parkinsonian monkeys,” Brain, 2002, 125: 2190-2200.

Andersen, A.H.
, Z. Zhang, T. Barber, W.S. Rayens, J. Zhang, R. Grondin, P. Hardy, G.A. Gerhardt, and D.M. Gash, “Functional MRI studies in awake rhesus monkeys:  Methodological and analytical strategies,” Journal of Neuroscience Methods, 2002, 118(2): 141-152.

Smith, C.D.,  A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison, “Women at high risk for Alzheimer’s disease show increased parietal activation in a letter fluency task,” Neurology, 2002, 58(8): 1197-20.   

Zhang, Z., A.H. Andersen, R. Grondin, T. Barber, R. Avison, G. Gerhardt, and D. M. Gash, “Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys,” NeuroImage, 2001, 14 (5): 1159-1167.    

Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison, “Differences in functional MRI activation by category in a visual confrontation naming task,” Journal of Neuroimaging, 2001, 11: 165-170.  

Kesler-West, M.L., A.H. Andersen, C.D. Smith, M.J. Avison, C.E. Davis, R.G. Avison, R.J. Kryscio, and L.X. Blonder, “Neural substrates of facial emotion processing using fMRI,” Cognitive Brain Research, 2001, 11: 213-226.  

Andersen
, A.H., W.S.Rayens, R.-C. Li, and L.X. Blonder, “Mathematical problems in the application of multilinear models to facial emotion processing experiments,” Proc. SPIE, Mathematical Modeling, Estimation, and Imaging  (D.C. Wilson, H.D. Tagare, F.L. Bookstein, F.J. Preteux, E.R. Dougherty, Editors) Vol. 4121, pp. 77-87, San Diego (2000) .

Zhang, Z., A.H. Andersen, C. Smith, R. Grondin, G. Gerhardt, and D. Gash, “Motor slowing and Parkinsonian signs in aging rhesus monkeys mirror human aging,” Journal of Gerontology, 2000, 55A, B473-B480.

Berger J.R., A. Nath, R.N. Greenberg, A.H. Andersen, R.A. Greene, A. Bognar, and M.J. Avison, “Cerebrovascular changes in the basal ganglia with HIV dementia,” Neurology, February 2000, 54(4):921-6

Zhang, Z., A.H. Andersen, M.J. Avison, G.A. Gerhardt, and D.M. Gash, “Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys,” Brain Research, January 2000, 852: 290-296 .  

Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison, “Altered brain activation in normal subjects at risk for Alzheimer’s disease,” Neurology, October 1999, 53(7): 1391-1396.  

Chen, Q., A.H. Andersen, Z. Zhang, A. Ovadia, W.A. Cass, D.M. Gash, and M.J. Avison, “Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys,” Experimental Neurology, July 1999, 158 (1): 63-75.  

Andersen, A.H.
, D.M. Gash, and M.J. Avison, “Principal component analysis of the dynamic response measured by fMRI:  A generalized linear systems framework,” Magnetic Resonance Imaging, July 1999, 17 (6): 795-815.

Andersen A.H.,
Z. Zhang, M. Zhang, D.M. Gash, and M.J. Avison, “Age-associated changes in rhesus CNS composition identified by MRI,” Brain Research, May 1999, 829: 90-98.  

Smith, C.D., E.R. Trevathan, M. Zhang, A.H. Andersen, and M.J. Avison, “Functional MRI evidence for task-specific activation of developmentally abnormal visual association cortex.  Annals of Neurology, 1999, 45: 515-518.  

Andersen, A.H
., “On the Rician distribution of noisy MRI data,” Magnetic Resonance in Medicine, 1996, 36: 331-333.  

Andersen, A.H.
, and J.E. Kirsch, “Analysis of noise in phase contrast MR imaging,”  Medical Physics, 1996, 23 (6): 857-869.

Chen Q.C., A.H. Andersen, Z. Zhang, A. Ovadia, D.M. Gash, and M.J. Avison, “Mapping drug-induced changes in cerebral R2* by multiple gradient recalled echo functional MRI,  Magnetic Resonance Imaging, 1996, 14 (5): 469-476.  

Smith C.D., A.H. Andersen, Q. Chen, L.X. Blonder, J.E. Kirsch, and M.J. Avison,  “Cortical activation in confrontation naming.,” NeuroReport, 1996; 7 (3): 781-785.

 

 

 

 

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